Benjamin L. King
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View article: Molecular Mechanisms Underlying Response to Influenza in Grey Seals (<i>Halichoerus grypus</i>), a Potential Wild Reservoir
Molecular Mechanisms Underlying Response to Influenza in Grey Seals (<i>Halichoerus grypus</i>), a Potential Wild Reservoir Open
RNA viruses are infamous for their ability to cross species barriers, posing threats to global health and security. Influenza A virus (IAV) is naturally found in avian hosts but periodically spills over into marine wildlife. IAV outbreaks …
View article: Anorgasmia following initiation of GLP-1 agonist
Anorgasmia following initiation of GLP-1 agonist Open
Introduction According to the Obesity Medicine Association, obesity is a chronic, progressive, relapsing, multifactorial and treatable neurobehavioral disease. A small number of drugs have been approved by the Food & Drug Administration (F…
View article: Comparing demersal fish and large mobile decapod crustacean assemblages in nearshore marine habitats across a boreal-sub-Arctic gradient using baited cameras
Comparing demersal fish and large mobile decapod crustacean assemblages in nearshore marine habitats across a boreal-sub-Arctic gradient using baited cameras Open
Arctic and sub-Arctic ecosystems are experiencing changes in environmental conditions, altering marine biodiversity through shifts in species distributions and composition. Coastal ecosystems in northern environments are vulnerable to cont…
View article: Reusable tutorials for using cloud-based computing environments for the analysis of bacterial gene expression data from bulk RNA sequencing
Reusable tutorials for using cloud-based computing environments for the analysis of bacterial gene expression data from bulk RNA sequencing Open
This manuscript describes the development of a resource module that is part of a learning platform named “NIGMS Sandbox for Cloud-based Learning” https://github.com/NIGMS/NIGMS-Sandbox. The overall genesis of the Sandbox is described in th…
View article: Remarkably High Repeat Content in the Genomes of Sparrows: The Importance of Genome Assembly Completeness for Transposable Element Discovery
Remarkably High Repeat Content in the Genomes of Sparrows: The Importance of Genome Assembly Completeness for Transposable Element Discovery Open
Transposable elements (TE) play critical roles in shaping genome evolution. Highly repetitive TE sequences are also a major source of assembly gaps making it difficult to fully understand the impact of these elements on host genomes. The i…
View article: Color-Flu Fluorescent Reporter Influenza A Viruses Allow for In Vivo Studies of Innate Immune Function in Zebrafish
Color-Flu Fluorescent Reporter Influenza A Viruses Allow for In Vivo Studies of Innate Immune Function in Zebrafish Open
Influenza virus infection can cause severe respiratory disease and is estimated to cause millions of illnesses annually. Studies on the contribution of the innate immune response to influenza A virus (IAV) to viral pathogenesis may yield n…
View article: Multi-spectral Fluorescent Reporter Influenza A Viruses Allow for<i>in vivo</i>Studies of Innate Immune Function in Zebrafish
Multi-spectral Fluorescent Reporter Influenza A Viruses Allow for<i>in vivo</i>Studies of Innate Immune Function in Zebrafish Open
Influenza virus infection can cause severe respiratory disease and is estimated to cause millions of illnesses annually. Studies of the contribution of the innate immune response to influenza A virus (IAV) to viral pathogenesis may yield n…
View article: Remarkably high repeat content in the genomes of sparrows: the importance of genome assembly completeness for transposable element discovery
Remarkably high repeat content in the genomes of sparrows: the importance of genome assembly completeness for transposable element discovery Open
Transposable elements (TE) play critical roles in shaping genome evolution. However, the highly repetitive sequence content of TEs is a major source of assembly gaps. This makes it difficult to decipher the impact of these elements on the …
View article: A New Phenotype in <i>Candida</i> -Epithelial Cell Interaction Distinguishes Colonization- versus Vulvovaginal Candidiasis-Associated Strains
A New Phenotype in <i>Candida</i> -Epithelial Cell Interaction Distinguishes Colonization- versus Vulvovaginal Candidiasis-Associated Strains Open
Despite a high incidence of VVC, we still have a poor understanding of this female-specific disease whose negative impact on women’s quality of life has become a public health issue. It is not yet possible to determine by genotype or labor…
View article: Editorial: Zebrafish: An emerging model to study the cellular dynamics of inflammation in development, regeneration, and disease
Editorial: Zebrafish: An emerging model to study the cellular dynamics of inflammation in development, regeneration, and disease Open
EDITORIAL article Front. Cell Dev. Biol., 09 January 2023Sec. Molecular and Cellular Pathology Volume 10 - 2022 | https://doi.org/10.3389/fcell.2022.1102381
View article: medna-metadata: an open-source data management system for tracking environmental DNA samples and metadata
medna-metadata: an open-source data management system for tracking environmental DNA samples and metadata Open
Motivation Environmental DNA (eDNA), as a rapidly expanding research field, stands to benefit from shared resources including sampling protocols, study designs, discovered sequences, and taxonomic assignments to sequences. High-quality com…
View article: Rearrangement in the Hypervariable Region of JC Polyomavirus Genomes Isolated from Patient Samples and Impact on Transcription Factor-Binding Sites and Disease Outcomes
Rearrangement in the Hypervariable Region of JC Polyomavirus Genomes Isolated from Patient Samples and Impact on Transcription Factor-Binding Sites and Disease Outcomes Open
JC polyomavirus (JCPyV) is the causative agent of the fatal, incurable, neurological disease, progressive multifocal leukoencephalopathy (PML). The virus is present in most of the adult population as a persistent, asymptotic infection in t…
View article: PI3K/AKT/mTOR Signaling Pathway Is Required for JCPyV Infection in Primary Astrocytes
PI3K/AKT/mTOR Signaling Pathway Is Required for JCPyV Infection in Primary Astrocytes Open
Astrocytes are a main target of JC polyomavirus (JCPyV) in the central nervous system (CNS), where the destruction of these cells, along with oligodendrocytes, leads to the fatal disease progressive multifocal leukoencephalopathy (PML). Th…
View article: Cetylpyridinium chloride (CPC) reduces zebrafish mortality from influenza infection: Super-resolution microscopy reveals CPC interference with multiple protein interactions with phosphatidylinositol 4,5-bisphosphate in immune function
Cetylpyridinium chloride (CPC) reduces zebrafish mortality from influenza infection: Super-resolution microscopy reveals CPC interference with multiple protein interactions with phosphatidylinositol 4,5-bisphosphate in immune function Open
The COVID-19 pandemic raises significance for a potential influenza therapeutic compound, cetylpyridinium chloride (CPC), which has been extensively used in personal care products as a positively-charged quaternary ammonium antibacterial a…
View article: The MAPK/ERK Pathway and the Role of DUSP1 in JCPyV Infection of Primary Astrocytes
The MAPK/ERK Pathway and the Role of DUSP1 in JCPyV Infection of Primary Astrocytes Open
JC polyomavirus (JCPyV) is a neuroinvasive pathogen causing a fatal, demyelinating disease of the central nervous system (CNS) known as progressive multifocal leukoencephalopathy (PML). Within the CNS, JCPyV predominately targets two cell …
View article: Meta‐analysis: Congruence of genomic and phenotypic differentiation across diverse natural study systems
Meta‐analysis: Congruence of genomic and phenotypic differentiation across diverse natural study systems Open
Linking genotype to phenotype is a primary goal for understanding the genomic underpinnings of evolution. However, little work has explored whether patterns of linked genomic and phenotypic differentiation are congruent across natural stud…
View article: Paid Parental Leave Policies Among <i>U.S. News & World Report</i> 2020-2021 Best Hospitals and Best Hospitals for Cancer
Paid Parental Leave Policies Among <i>U.S. News & World Report</i> 2020-2021 Best Hospitals and Best Hospitals for Cancer Open
This cross-sectional study examines paid parental leave policies for faculty and staff physicians at leading US hospitals and cancer centers.
View article: Modeling Virus-Induced Inflammation in Zebrafish: A Balance Between Infection Control and Excessive Inflammation
Modeling Virus-Induced Inflammation in Zebrafish: A Balance Between Infection Control and Excessive Inflammation Open
The inflammatory response to viral infection in humans is a dynamic process with complex cell interactions that are governed by the immune system and influenced by both host and viral factors. Due to this complexity, the relative contribut…
View article: Deleterious impacts of inactivity and beneficial impacts of neuromuscular electrical stimulation on muscle structure and function in the zebrafish model of Duchenne Muscular Dystrophy
Deleterious impacts of inactivity and beneficial impacts of neuromuscular electrical stimulation on muscle structure and function in the zebrafish model of Duchenne Muscular Dystrophy Open
Although it is known that inactivity is deleterious for healthy individuals, less is known about the consequences of inactivity on muscle disease. Reduced activity is frequently encouraged for individuals with congenital muscular dystrophi…
View article: Additional file 1 of Chronic cortisol exposure in early development leads to neuroendocrine dysregulation in adulthood
Additional file 1 of Chronic cortisol exposure in early development leads to neuroendocrine dysregulation in adulthood Open
Additional file 1: ANOVA of tissue cortisol levels shown in Fig. 1b.