Benjamin Kirchweger
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View article: Supercritical fluid-based protocol for the identification and quantitation of triterpenoids in commercial Inonotus obliquus (chaga) samples
Supercritical fluid-based protocol for the identification and quantitation of triterpenoids in commercial Inonotus obliquus (chaga) samples Open
Inonotus obliquus is a fungal pathogen that parasitizes the trunks of broadleaved tree species. The sclerotia of this fungus, so-called chaga, show a broad range of traditional and medicinal uses. The increasing market for chaga supplement…
View article: Pharmacological in vitro profiling of Buddleja officinalis flower extracts in the context of dry eye disease
Pharmacological in vitro profiling of Buddleja officinalis flower extracts in the context of dry eye disease Open
The results of this study demonstrate pharmacological potential of B. officinalis flowers for the treatment of DED pathology with BO-LLE exerting a slightly more beneficial profile than BO-HE.
View article: Combining the Strengths of MS and NMR in Biochemometrics: A Case Study on <i>Buddleja officinalis</i>
Combining the Strengths of MS and NMR in Biochemometrics: A Case Study on <i>Buddleja officinalis</i> Open
Biochemometrics has emerged as promising strategy for the targeted identification of bioactive constituents from natural sources. It is based on the correlation of bioactivity data with chemical data to reveal constituents contributing to …
View article: Discovery of anti-SARS-CoV-2 secondary metabolites from the heartwood of Pterocarpus santalinus using multi-informative molecular networking
Discovery of anti-SARS-CoV-2 secondary metabolites from the heartwood of Pterocarpus santalinus using multi-informative molecular networking Open
A pigment-depleted extract from the heartwood of Pterocarpus santalinus L. f. (PS-DE) showed promising anti-SARS-CoV-2 activity with an IC 50 of 29.9 μg/mL in Caco-2-F03 cells. To determine the potential active constituents within the extr…
View article: Identification of Natural Products Inhibiting SARS-CoV-2 by Targeting Viral Proteases: A Combined in Silico and in Vitro Approach
Identification of Natural Products Inhibiting SARS-CoV-2 by Targeting Viral Proteases: A Combined in Silico and in Vitro Approach Open
In this study, an integrated in silico-in vitro approach was employed to discover natural products (NPs) active against SARS-CoV-2. The two SARS-CoV-2 viral proteases, i.e., main protease (Mpro) and papain-like protease (PL…
View article: The role of<i>Caenorhabditis elegans</i>in the discovery of natural products for healthy aging
The role of<i>Caenorhabditis elegans</i>in the discovery of natural products for healthy aging Open
This review covers the role of the nematode Caenorhabditis elegans as a whole organism model to study natural products for healthy aging. Literature between 2012 and 2023 was comprehensively analysed and is presented in a concise way.
View article: Molecular Networking Unveils Anti-Sars-Cov-2 Constituents from Traditionally Used Remedies
Molecular Networking Unveils Anti-Sars-Cov-2 Constituents from Traditionally Used Remedies Open
View article: In Silico and In Vitro Approach to Assess Direct Allosteric AMPK Activators from Nature
In Silico and In Vitro Approach to Assess Direct Allosteric AMPK Activators from Nature Open
The 5′-adenosine monophosphate-activated protein kinase (AMPK) is an important metabolic regulator. Its allosteric drug and metabolite binding (ADaM) site was identified as an attractive target for direct AMPK activation and holds promise …
View article: Expanding the Biological Properties of Alkannins and Shikonins: Their Impact on Adipogenesis and Life Expectancy in Nematodes
Expanding the Biological Properties of Alkannins and Shikonins: Their Impact on Adipogenesis and Life Expectancy in Nematodes Open
Alkannin, shikonin (A/S) and their derivatives are naturally occurring hydroxynaphthoquinones biosynthesized in some species of the Boraginaceae family. These natural compounds have been extensively investigated for their biological proper…
View article: Azepine-Indole Alkaloids From Psychotria nemorosa Modulate 5-HT2A Receptors and Prevent in vivo Protein Toxicity in Transgenic Caenorhabditis elegans
Azepine-Indole Alkaloids From Psychotria nemorosa Modulate 5-HT2A Receptors and Prevent in vivo Protein Toxicity in Transgenic Caenorhabditis elegans Open
Nemorosine A ( 1 ) and fargesine ( 2 ), the main azepine-indole alkaloids of Psychotria nemorosa , were explored for their pharmacological profile on neurodegenerative disorders (NDs) applying a combined in silico – in vitro – in vivo appr…
View article: Workflow for Segmentation of Caenorhabditis elegans from Fluorescence Images for the Quantitation of Lipids
Workflow for Segmentation of Caenorhabditis elegans from Fluorescence Images for the Quantitation of Lipids Open
The small and transparent nematode Caenorhabditis elegans is increasingly employed for phenotypic in vivo chemical screens. The influence of compounds on worm body fat stores can be assayed with Nile red staining and imaging. Segmentation …
View article: A robust and miniaturized screening platform to study natural products affecting metabolism and survival in Caenorhabditis elegans
A robust and miniaturized screening platform to study natural products affecting metabolism and survival in Caenorhabditis elegans Open
View article: In Silico Workflow for the Discovery of Natural Products Activating the G Protein-Coupled Bile Acid Receptor 1
In Silico Workflow for the Discovery of Natural Products Activating the G Protein-Coupled Bile Acid Receptor 1 Open
The G protein-coupled bile acid receptor (GPBAR1) has been recognized as a promising new target for the treatment of diverse diseases, including obesity, type 2 diabetes, fatty liver disease and atherosclerosis. The identification of novel…
View article: New natural GPBAR-1 modulators identified by combined in silico - in vitro screening
New natural GPBAR-1 modulators identified by combined in silico - in vitro screening Open
Als der G-Protein gekoppelte Gallensäurerezeptor 1 (GPBAR1) vor 15 Jahren entdeckt wurde, erkannte man ihn bald als verheißungsvolles Ziel für neue Medikamente. Ihn zu aktivieren könnte zukünftig Relevanz in der Therapie von verschiedenen …