Benjamin Ko
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View article: Contribution of thick ascending limb and distal convoluted tubule to glucose-induced hypercalciuria in healthy controls
Contribution of thick ascending limb and distal convoluted tubule to glucose-induced hypercalciuria in healthy controls Open
Sugar increases urine calcium and magnesium as well as kidney stone and bone disease risk. Our study provided new insights into the underlying mechanism as we gave healthy subjects an oral glucose load and used newer tools such as fraction…
View article: Nephrology Trainee Education Needs Assessment: Five Years and a Pandemic Later
Nephrology Trainee Education Needs Assessment: Five Years and a Pandemic Later Open
Seventy-four percent of nephrology fellows reported exclusively receiving virtual didactics during the early part of the coronavirus disease 2019 (COVID-19) pandemic.1 In response to this rapid shift to online instruction, we sought to des…
View article: Interleukin 6 mediated activation of the mineralocorticoid receptor in the aldosterone-sensitive distal nephron
Interleukin 6 mediated activation of the mineralocorticoid receptor in the aldosterone-sensitive distal nephron Open
Hypertension is characterized by increased sodium (Na + ) reabsorption along the aldosterone-sensitive distal nephron (ASDN) as well as chronic systemic inflammation. Interleukin-6 (IL-6) is thought to be a mediator of this inflammatory pr…
View article: The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension
The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension Open
Background: Renal T cells contribute importantly to hypertension, but the underlying mechanism is incompletely understood. We reported that CD8Ts directly stimulate distal convoluted tubule cells (DCTs) to increase NCC (sodium chloride co-…
View article: The Pharmacological Inhibition of CaMKII Regulates Sodium Chloride Cotransporter Activity in mDCT15 Cells
The Pharmacological Inhibition of CaMKII Regulates Sodium Chloride Cotransporter Activity in mDCT15 Cells Open
The thiazide-sensitive sodium chloride cotransporter (NCC) in the distal convoluted tubule is responsible for reabsorbing up to one-tenth of the total filtered load of sodium in the kidney. The actin cytoskeleton is thought to regulate var…
View article: Mechanisms for falling urine pH with age in stone formers
Mechanisms for falling urine pH with age in stone formers Open
One of the main functions of the kidney is to excrete an acid load derived from both dietary and endogenous sources, thus maintaining the pH of other fluids in the body. Urine pH is also of particular interest in stone formers, since it de…
View article: Zinc deficiency induces hypertension by promoting renal Na<sup>+</sup> reabsorption
Zinc deficiency induces hypertension by promoting renal Na<sup>+</sup> reabsorption Open
Zn 2+ deficiency (ZnD) is a common comorbidity of many chronic diseases. In these settings, ZnD exacerbates hypertension. Whether ZnD alone is sufficient to alter blood pressure (BP) is unknown. To explore the role of Zn 2+ in BP regulatio…
View article: The complexities of lithium
The complexities of lithium Open
This is a editorial focus written to highlight the findings by Yang et al in the article “The Soluble (Pro)Renin Receptor Does Not Influence Lithium‐Induced Diabetes Insipidus but Does Provoke Beiging of White Adipose Tissue in Mice.”
View article: The sodium chloride cotransporter (NCC) and epithelial sodium channel (ENaC) associate
The sodium chloride cotransporter (NCC) and epithelial sodium channel (ENaC) associate Open
The thiazide-sensitive sodium chloride cotransporter (NCC) and the epithelial sodium channel (ENaC) are two of the most important determinants of salt balance and thus systemic blood pressure. Abnormalities in either result in profound cha…
View article: Interleukin-17A Regulates Renal Sodium Transporters and Renal Injury in Angiotensin II–Induced Hypertension
Interleukin-17A Regulates Renal Sodium Transporters and Renal Injury in Angiotensin II–Induced Hypertension Open
Angiotensin II–induced hypertension is associated with an increase in T-cell production of interleukin-17A (IL-17A). Recently, we reported that IL-17A −/− mice exhibit blunted hypertension, preserved natriuresis in response to a saline cha…