Benjamin Kroeger
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View article: Hippo signaling regulates the nuclear behavior and DNA binding times of YAP and TEAD to control transcription
Hippo signaling regulates the nuclear behavior and DNA binding times of YAP and TEAD to control transcription Open
Over the past two decades, genetic and proteomic screens have identified the Hippo pathway as a complex signaling network that controls tissue growth and human cancer. Despite these advances, our understanding of how Hippo signaling regula…
View article: Hippo signalling regulates the nuclear behaviour and DNA dwell times of YAP and TEAD to control transcription
Hippo signalling regulates the nuclear behaviour and DNA dwell times of YAP and TEAD to control transcription Open
Over the past two decades, genetic and proteomic screens have enabled the discovery and elucidation of the Hippo pathway as a complex signalling network that controls tissue growth and cell fate and which is of major importance for human c…
View article: Basal spot junctions of epithelial tissues respond to morphogenetic forces and regulate Hippo signaling
Basal spot junctions of epithelial tissues respond to morphogenetic forces and regulate Hippo signaling Open
SUMMARY Organ size is controlled by numerous factors including mechanical forces, which are mediated in part by the Hippo pathway. In growing Drosophila melanogaster epithelial tissues, cytoskeletal tension influences Hippo signalling by m…
View article: <i>Drosophila</i> Sex Peptide controls the assembly of lipid microcarriers in seminal fluid
<i>Drosophila</i> Sex Peptide controls the assembly of lipid microcarriers in seminal fluid Open
Significance Seminal fluid plays a critical role in reprogramming female physiology and behavior to promote male reproductive success. We show, in the fruit fly, that specific seminal proteins, including the archetypal “female-reprogrammin…
View article: Glutamine deprivation alters the origin and function of cancer cell exosomes
Glutamine deprivation alters the origin and function of cancer cell exosomes Open
Exosomes are secreted extracellular vesicles carrying diverse molecular cargos, which can modulate recipient cell behaviour. They are thought to derive from intraluminal vesicles formed in late endosomal multivesicular bodies (MVBs). An al…
View article: <i>Drosophila</i>Sex Peptide Controls the Assembly of Lipid Microcarriers in Seminal Fluid
<i>Drosophila</i>Sex Peptide Controls the Assembly of Lipid Microcarriers in Seminal Fluid Open
Seminal fluid plays an essential role in promoting male reproductive success and modulating female physiology and behaviour. In the fruit fly, Drosophila melanogaster , Sex Peptide (SP) is the best-characterised protein mediator of these e…
View article: Glutamine Deprivation Regulates the Origin and Function of Cancer Cell Exosomes
Glutamine Deprivation Regulates the Origin and Function of Cancer Cell Exosomes Open
SUMMARY Exosomes are secreted extracellular vesicles (EVs) carrying diverse cargos, which can modulate recipient cell behaviour. They are thought to derive from intraluminal vesicles formed in late endosomal multivesicular bodies (MVBs). A…
View article: The dPix-Git complex is essential to coordinate epithelial morphogenesis and regulate myosin during Drosophila egg chamber development
The dPix-Git complex is essential to coordinate epithelial morphogenesis and regulate myosin during Drosophila egg chamber development Open
How biochemical and mechanical information are integrated during tissue development is a central question in morphogenesis. In many biological systems, the PIX-GIT complex localises to focal adhesions and integrates both physical and chemi…
View article: Rab‐mediated trafficking in the secondary cells of <i>Drosophila</i> male accessory glands and its role in fecundity
Rab‐mediated trafficking in the secondary cells of <i>Drosophila</i> male accessory glands and its role in fecundity Open
The male seminal fluid contains factors that affect female post‐mating behavior and physiology. In Drosophila, most of these factors are secreted by the two epithelial cell types that make up the male accessory gland: the main and secondar…
View article: Rab-mediated trafficking in the secondary cells of Drosophila male accessory glands and its role in fecundity
Rab-mediated trafficking in the secondary cells of Drosophila male accessory glands and its role in fecundity Open
It is known that the male seminal fluid contains factors that affect female post-mating behavior and physiology. In Drosophila, most of these factors are secreted by the two epithelial cell types that make up the male accessory gland: the …
View article: The genetic regulation and subcellular dynamics of secretory and endolysosomal organelles of Drosophila secondary cells
The genetic regulation and subcellular dynamics of secretory and endolysosomal organelles of Drosophila secondary cells Open
Secretory processes underpin the emergence of cellular diversity in complex multicellular organisms. However, our understanding of the basic mechanisms controlling the different secretory and endosomal compartments involved remains surpris…
View article: Regulation of Dense-Core Granule Replenishment by Autocrine BMP Signalling in Drosophila Secondary Cells
Regulation of Dense-Core Granule Replenishment by Autocrine BMP Signalling in Drosophila Secondary Cells Open
Regulated secretion by glands and neurons involves release of signalling molecules and enzymes selectively concentrated in dense-core granules (DCGs). Although we understand how many secretagogues stimulate DCG release, how DCG biogenesis …