Benjamin L. Green
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View article: Myeloid derived suppressor cell depletion for the treatment of hepatoblastoma 4283
Myeloid derived suppressor cell depletion for the treatment of hepatoblastoma 4283 Open
Description Introduction Hepatoblastoma (HB) is the most common form of liver cancer in childhood. Neutrophilic myeloid derived suppressor cells (PMN-MDSCs) are immunosuppressive cells recruited to liver tumors. Depletion of PMN-MDSCs has …
View article: Data from Spatial Analysis of Hereditary Diffuse Gastric Cancer Reveals Indolent Phenotype of Signet Ring Cell Precursors
Data from Spatial Analysis of Hereditary Diffuse Gastric Cancer Reveals Indolent Phenotype of Signet Ring Cell Precursors Open
Germline CDH1 loss-of-function mutations are causally linked to an increased lifetime risk of diffuse gastric cancer (DGC). Early, multifocal signet ring cell (SRC) lesions are ubiquitous among CDH1 variant carriers, yet only…
View article: Supplementary Figure S1 from Spatial Analysis of Hereditary Diffuse Gastric Cancer Reveals Indolent Phenotype of Signet Ring Cell Precursors
Supplementary Figure S1 from Spatial Analysis of Hereditary Diffuse Gastric Cancer Reveals Indolent Phenotype of Signet Ring Cell Precursors Open
Leading edge analysis following GSEA demonstrating enriched pathways associated with ECM remodeling between SRC and EP.
View article: Table S3 from Spatial Analysis of Hereditary Diffuse Gastric Cancer Reveals Indolent Phenotype of Signet Ring Cell Precursors
Table S3 from Spatial Analysis of Hereditary Diffuse Gastric Cancer Reveals Indolent Phenotype of Signet Ring Cell Precursors Open
Marker genes used for annotating major cell types in single cell RNA sequencing analysis.
View article: Table S2 from Spatial Analysis of Hereditary Diffuse Gastric Cancer Reveals Indolent Phenotype of Signet Ring Cell Precursors
Table S2 from Spatial Analysis of Hereditary Diffuse Gastric Cancer Reveals Indolent Phenotype of Signet Ring Cell Precursors Open
Antibody panel used in co-detection by indexing (CODEX) multiplexed immunofluorescence tissue imaging.
View article: Table S1 from Spatial Analysis of Hereditary Diffuse Gastric Cancer Reveals Indolent Phenotype of Signet Ring Cell Precursors
Table S1 from Spatial Analysis of Hereditary Diffuse Gastric Cancer Reveals Indolent Phenotype of Signet Ring Cell Precursors Open
Patient demographics, genetic, and histopathology characteristics.
View article: Table S4 from Spatial Analysis of Hereditary Diffuse Gastric Cancer Reveals Indolent Phenotype of Signet Ring Cell Precursors
Table S4 from Spatial Analysis of Hereditary Diffuse Gastric Cancer Reveals Indolent Phenotype of Signet Ring Cell Precursors Open
Additional SRC-enriched markers from single cell RNA sequencing analysis.
View article: The Gut Microbiome Controls Liver Tumors via the Vagus Nerve
The Gut Microbiome Controls Liver Tumors via the Vagus Nerve Open
Liver cancer ranks amongst the deadliest cancers. Nerves have emerged as an understudied regulator of tumor progression. The parasympathetic vagus nerve influences systemic immunity via acetylcholine (ACh). Whether cholinergic neuroimmune …
View article: Supplementary Figure 3 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis
Supplementary Figure 3 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis Open
GSEA of T cell-specific gene sets related to (A) activation, costimulation, and (B) exhaustion comparing SRC to NEP.
View article: Supplementary Figure 6 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis
Supplementary Figure 6 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis Open
Representative slides at 20x magnification from every IHC specimen used for quantification.
View article: Supplementary Table 2 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis
Supplementary Table 2 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis Open
Generation of second messenger molecules.
View article: Supplementary Figure 7 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis
Supplementary Figure 7 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis Open
Heatmap of CIBERSORTx data from Figure 3A.
View article: Supplementary Table 2 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis
Supplementary Table 2 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis Open
Generation of second messenger molecules.
View article: Supplementary Figure 4 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis
Supplementary Figure 4 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis Open
GSEA plots comparing (A) oxidative phosphorylation, (B) glycolysis, and (C) fatty acid oxidation gene sets in SRC compared with NEP.
View article: Supplementary Table 1 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis
Supplementary Table 1 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis Open
Genes from RNAseq experiment comparing SRC vs. NEP.
View article: Supplementary Figure 4 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis
Supplementary Figure 4 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis Open
GSEA plots comparing (A) oxidative phosphorylation, (B) glycolysis, and (C) fatty acid oxidation gene sets in SRC compared with NEP.
View article: Supplementary Figure 2 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis
Supplementary Figure 2 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis Open
GSEA comparing SRC to NEP using gene sets for parenchymal gastric cells.
View article: Supplementary Figure 6 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis
Supplementary Figure 6 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis Open
Representative slides at 20x magnification from every IHC specimen used for quantification.
View article: Supplementary Figure 2 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis
Supplementary Figure 2 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis Open
GSEA comparing SRC to NEP using gene sets for parenchymal gastric cells.
View article: Data from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis
Data from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis Open
Stage IA gastric adenocarcinoma, characterized by foci of intramucosal signet ring cells (SRC), is found in nearly all asymptomatic patients with germline pathogenic CDH1 variants and hereditary diffuse gastric cancer syndrome (HDGC…
View article: Data from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis
Data from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis Open
Stage IA gastric adenocarcinoma, characterized by foci of intramucosal signet ring cells (SRC), is found in nearly all asymptomatic patients with germline pathogenic CDH1 variants and hereditary diffuse gastric cancer syndrome (HDGC…
View article: Supplementary Table 1 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis
Supplementary Table 1 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis Open
Genes from RNAseq experiment comparing SRC vs. NEP.
View article: Supplementary Table 3 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis
Supplementary Table 3 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis Open
Genes from GSEA involving parenchymal stomach cells, metabolism, and T cell signaling.
View article: Supplementary Table 3 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis
Supplementary Table 3 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis Open
Genes from GSEA involving parenchymal stomach cells, metabolism, and T cell signaling.
View article: Supplementary Figure 3 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis
Supplementary Figure 3 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis Open
GSEA of T cell-specific gene sets related to (A) activation, costimulation, and (B) exhaustion comparing SRC to NEP.
View article: Supplementary Figure 1 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis
Supplementary Figure 1 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis Open
Pathway analysis of Reactome database based on the variations of read depth.
View article: Supplementary Figure 5 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis
Supplementary Figure 5 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis Open
GSEA plots of carcinogenesis gene sets in SRC compared with NEP.
View article: Supplementary Figure 8 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis
Supplementary Figure 8 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis Open
GSEA plots of Treg and NK cell gene sets in SRC compared with NEP.
View article: Supplementary Figure 1 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis
Supplementary Figure 1 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis Open
Pathway analysis of Reactome database based on the variations of read depth.
View article: Supplementary Figure 8 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis
Supplementary Figure 8 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis Open
GSEA plots of Treg and NK cell gene sets in SRC compared with NEP.