Benjamin L. Hill
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View article: Mapping of a Regulatory Site of the Escherichia coli ADP-Glucose Pyrophosphorylase
Mapping of a Regulatory Site of the Escherichia coli ADP-Glucose Pyrophosphorylase Open
The enzyme ADP-glucose pyrophosphorylase (ADP-Glc PPase) controls the biosynthesis of glycogen in bacteria and starch in plants. It is regulated by various activators in different organisms according to their metabolic characteristics. In …
View article: Resurrecting the Regulatory Properties of the Ostreococcus tauri ADP-Glucose Pyrophosphorylase Large Subunit
Resurrecting the Regulatory Properties of the Ostreococcus tauri ADP-Glucose Pyrophosphorylase Large Subunit Open
ADP-glucose pyrophosphorylase (ADP-Glc PPase) catalyzes the first committed step for the synthesis of glycogen in cyanobacteria and starch in green algae and plants. The enzyme from cyanobacteria is homotetrameric (α4), while that from gre…
View article: Allosteric Control of Substrate Specificity of the Escherichia coli ADP-Glucose Pyrophosphorylase
Allosteric Control of Substrate Specificity of the Escherichia coli ADP-Glucose Pyrophosphorylase Open
The substrate specificity of enzymes is crucial to control the fate of metabolites to different pathways. However, there is growing evidence that many enzymes can catalyze alternative reactions. This promiscuous behavior has important impl…
View article: On the stability of nucleoside diphosphate glucose metabolites: implications for studies of plant carbohydrate metabolism
On the stability of nucleoside diphosphate glucose metabolites: implications for studies of plant carbohydrate metabolism Open
Nucleoside diphosphate sugars (NDP-sugars) are the substrates for biosynthesis of oligo- and polysaccharides, such as starch and cellulose, and are also required for biosynthesis of nucleotides, ascorbic acid, several cofactors, glycoprote…
View article: Studies Into the Allosteric Regulation of ADP-Glucose Pyrophosphorylases
Studies Into the Allosteric Regulation of ADP-Glucose Pyrophosphorylases Open
The synthesis of glycogen in bacteria and starch in plants is allosterically controlled by the production of ADP-glucose by ADP-glucose pyrophosphorylase. Using computational studies, site directed mutagenesis, and kinetic characterization…