Benjamin L. Schulz
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View article: Residual barley proteins in brewers' spent grains: Quantitative composition and implications for food ingredient applications
Residual barley proteins in brewers' spent grains: Quantitative composition and implications for food ingredient applications Open
View article: Regulation of <i>N</i>-glycosylation efficiency by eukaryotic oligosaccharyltransferase
Regulation of <i>N</i>-glycosylation efficiency by eukaryotic oligosaccharyltransferase Open
Oligosaccharyltransferase (OST) catalyses the key step of N -glycosylation, transferring immature N -glycans to select Asn residues in nascent proteins in the endoplasmic reticulum (ER). Asn are more likely to be glycosylated in the contex…
View article: What’s left from the brew? Investigating residual barley proteins in spent grains for downstream valorization opportunities
What’s left from the brew? Investigating residual barley proteins in spent grains for downstream valorization opportunities Open
Brewer’s spent grain (BSG) is the major side-stream from beer production but remains highly underutilized. While the direct use of BSG as a food ingredient is limited due to subpar techno- functionality, the vast amounts and fairly high pr…
View article: Glycogenin is dispensable for normal liver glycogen metabolism and body glucose homeostasis
Glycogenin is dispensable for normal liver glycogen metabolism and body glucose homeostasis Open
Glycogen is a glucose-storage polysaccharide molecule present in animals, fungi and bacteria. The enzyme glycogenin can self-glycosylate, forming an oligosaccharide chain that primes glycogen synthesis. This priming role of glycogenin was …
View article: Post-acute sequelae of SARS-CoV-2 cardiovascular symptoms are associated with trace-level cytokines that affect cardiomyocyte function
Post-acute sequelae of SARS-CoV-2 cardiovascular symptoms are associated with trace-level cytokines that affect cardiomyocyte function Open
View article: Biomimetic Surface Nanoengineering of Biodegradable Zn‐Based Orthopedic Implants for Enhanced Biocompatibility and Immunomodulation
Biomimetic Surface Nanoengineering of Biodegradable Zn‐Based Orthopedic Implants for Enhanced Biocompatibility and Immunomodulation Open
Zinc (Zn) is gaining increased recognition as a biodegradable metal in biomedical applications but clinical translation is limited due to its poor biocompatibility. This study addresses these issues through an innovative biomimetic strateg…
View article: Cardiovascular symptoms of PASC are associated with trace-level cytokines that affect the function of human pluripotent stem cell derived cardiomyocytes
Cardiovascular symptoms of PASC are associated with trace-level cytokines that affect the function of human pluripotent stem cell derived cardiomyocytes Open
Globally, over 65 million individuals are estimated to suffer from post-acute sequelae of COVID-19 (PASC). A large number of individuals living with PASC experience cardiovascular symptoms (i.e. chest pain and heart palpitations) (PASC-CVS…
View article: The ABC toxin complex from <i>Yersinia entomophaga</i> can package three different cytotoxic components expressed from distinct genetic loci in an unfolded state: the structures of both shell and cargo
The ABC toxin complex from <i>Yersinia entomophaga</i> can package three different cytotoxic components expressed from distinct genetic loci in an unfolded state: the structures of both shell and cargo Open
Bacterial ABC toxin complexes (Tcs) comprise three core proteins: TcA, TcB and TcC. The TcA protein forms a pentameric assembly that attaches to the surface of target cells and penetrates the cell membrane. The TcB and TcC proteins assembl…
View article: Electron-Activated Dissociation and Collision-Induced Dissociation Glycopeptide Fragmentation for Improved Glycoproteomics
Electron-Activated Dissociation and Collision-Induced Dissociation Glycopeptide Fragmentation for Improved Glycoproteomics Open
Tandem mass spectrometry coupled with liquid chromatography (LC-MS/MS) has proven a versatile tool for the identification and quantification of proteins and their post-translational modifications (PTMs). Protein glycosylation is a critical…
View article: Capturing and Characterising Wild Yeast for Beer Brewing
Capturing and Characterising Wild Yeast for Beer Brewing Open
Beer is typically made using fermentation with Saccharomyces cerevisiae or Saccharomyces pastorianus , domesticated brewing yeasts. Historically, wild, non -Saccharomyces yeasts have also been frequently used in mixed culture fermentations…
View article: TcrXY is an acid-sensing two-component transcriptional regulator of Mycobacterium tuberculosis required for persistent infection
TcrXY is an acid-sensing two-component transcriptional regulator of Mycobacterium tuberculosis required for persistent infection Open
The ability of Mycobacterium tuberculosis (Mtb) to persist in the host complicates and prolongs tuberculosis (TB) patient chemotherapy. Here we demonstrate that a neglected two-component system (TCS) of Mtb, TcrXY, is an autoregulated acid…
View article: SAGA Complex Subunit Hfi1 Is Important in the Stress Response and Pathogenesis of Cryptococcus neoformans
SAGA Complex Subunit Hfi1 Is Important in the Stress Response and Pathogenesis of Cryptococcus neoformans Open
The Spt-Ada-Gcn Acetyltransferase (SAGA) complex is a highly conserved co-activator found across eukaryotes. It is composed of a number of modules which can vary between species, but all contain the core module. Hfi1 (known as TADA1 in Hom…
View article: The role of <i>N</i>-glycosylation in spike antigenicity for the SARS-CoV-2 gamma variant
The role of <i>N</i>-glycosylation in spike antigenicity for the SARS-CoV-2 gamma variant Open
The emergence of SARS-CoV-2 variants alters the efficacy of existing immunity towards the viral spike protein, whether acquired from infection or vaccination. Mutations that impact N-glycosylation of spike may be particularly important in …
View article: Covariance Clustering: Modelling Covariance in Designed Experiments When the Number of Variables is Greater than Experimental Units
Covariance Clustering: Modelling Covariance in Designed Experiments When the Number of Variables is Greater than Experimental Units Open
The size and complexity of datasets resulting from comparative research experiments in the agricultural domain is constantly increasing. Often the number of variables measured in an experiment exceeds the number of experimental units compo…
View article: Modulation of Endoplasmic Reticulum Stress Response Pathways by Respiratory Viruses
Modulation of Endoplasmic Reticulum Stress Response Pathways by Respiratory Viruses Open
Acute respiratory infections (ARIs) are amongst the leading causes of death and disability, and the greatest burden of disease impacts children, pregnant women, and the elderly. Respiratory viruses account for the majority of ARIs. The unf…
View article: High-Frequency Changes in Pilin Glycosylation Patterns during <i>Neisseria meningitidis</i> Serogroup a Meningitis Outbreaks in the African Meningitis Belt
High-Frequency Changes in Pilin Glycosylation Patterns during <i>Neisseria meningitidis</i> Serogroup a Meningitis Outbreaks in the African Meningitis Belt Open
In the meningitis belt of sub-Saharan Africa, there are cyclic meningococcal epidemics that coincide with clonal waves of Neisseria meningitidis carriage and invasive disease. In the framework of longitudinal colonization and diseas…
View article: Structure and antigenicity of divergent Henipavirus fusion glycoproteins
Structure and antigenicity of divergent Henipavirus fusion glycoproteins Open
In August 2022, a novel henipavirus (HNV) named Langya virus (LayV) was isolated from patients with severe pneumonic disease in China. This virus is closely related to Mòjiāng virus (MojV), and both are divergent from the bat-borne HNV mem…
View article: TcrXY is an acid-sensing two-component transcriptional regulator of Mycobacterium tuberculosis and a novel target for enhanced TB therapy
TcrXY is an acid-sensing two-component transcriptional regulator of Mycobacterium tuberculosis and a novel target for enhanced TB therapy Open
The ability of Mycobacterium tuberculosis (Mtb) to persist in the host complicates and prolongs tuberculosis (TB) patient chemotherapy. Here we demonstrate that a neglected two-component system (TCS) of Mtb, TcrXY, is an autoregulated acid…
View article: The role of<i>N</i>-glycosylation in spike antigenicity for the SARS-CoV-2 Gamma variant
The role of<i>N</i>-glycosylation in spike antigenicity for the SARS-CoV-2 Gamma variant Open
The emergence of SARS-CoV-2 variants alters the efficacy of existing immunity towards the viral spike protein, whether acquired from infection or vaccination. Mutations that impact N -glycosylation of spike may be particularly important in…
View article: Application of quantitative proteomics to discover biomarkers for tick resistance in cattle
Application of quantitative proteomics to discover biomarkers for tick resistance in cattle Open
Introduction Breeding for tick resistance is a sustainable alternative to control cattle ticks due to widespread resistance to acaricidal drugs and the lack of a protective vaccine. The most accurate method used to characterise the phenoty…
View article: On topology changes in quantum field theory and quantum gravity
On topology changes in quantum field theory and quantum gravity Open
Two singularity theorems can be proven if one attempts to let a Lorentzian cobordism interpolate between two topologically distinct manifolds. On the other hand, Cartier and DeWitt-Morette have given a rigorous definition for quantum field…
View article: Glycosylation and the global virome
Glycosylation and the global virome Open
The sugars that coat the outsides of viruses and host cells are key to successful disease transmission, but they remain understudied compared to other molecular features. Understanding the comparative zoology of glycosylation ‐ and harness…
View article: Glycosylation and the global virome
Glycosylation and the global virome Open
The sugars that coat the outsides of viruses and host cells are key to successful disease transmission, but they remain understudied compared to other molecular features. Understanding the comparative zoology of glycosylation - and harness…
View article: Metabolomics of Non-Saccharomyces Yeasts in Fermented Beverages
Metabolomics of Non-Saccharomyces Yeasts in Fermented Beverages Open
Fermented beverages have been consumed for millennia and today support a global industry producing diverse products. Saccharomyces yeasts currently dominate the fermented beverage industry, but consumer demands for alternative products wit…
View article: Proteomics and metabolomics reveal an abundant α-glucosidase drives sorghum fermentability for beer brewing
Proteomics and metabolomics reveal an abundant α-glucosidase drives sorghum fermentability for beer brewing Open
Sorghum ( Sorghum bicolor ), a grass native to Africa, is a popular alternative to barley for brewing beer. The importance of sorghum to beer brewing is increasing because it is a naturally gluten-free cereal and because climate change is …
View article: Metabolomics of Non-Saccharomyces Yeasts in Fermented Beverages
Metabolomics of Non-Saccharomyces Yeasts in Fermented Beverages Open
Fermented beverages have been consumed for millennia and today support a global industry producing diverse products. Saccharomyces yeasts currently dominate the fermented beverage industry, but consumer demands for alternative products wit…
View article: Proteomics and glycoproteomics of beer and wine
Proteomics and glycoproteomics of beer and wine Open
Beer and wine are fermented beverages that contain abundant proteins released from barley or grapes, and secreted from yeast. These proteins are associated with many quality attributes including turbidity, foamability, effervescence, flavo…
View article: Glycosylation and the global virome
Glycosylation and the global virome Open
The sugars that coat the outsides of viruses and host cells are key to successful disease transmission, but they remain understudied compared to other molecular features. Understanding the comparative zoology of glycosylation - and harness…
View article: Glycosylation and the global virome
Glycosylation and the global virome Open
The sugars that coat the outsides of viruses and host cells are key to successful disease transmission, but they remain understudied compared to other molecular features. Understanding the comparative zoology of glycosylation - and harness…
View article: Extended characterisation of five archival tick-borne viruses provides insights for virus discovery in Australian ticks
Extended characterisation of five archival tick-borne viruses provides insights for virus discovery in Australian ticks Open