Bryan Lau
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View article: Incidence of AIDS-defining Illness by Cancer Status in an Observational Study among Medicaid Beneficiaries Living with HIV in the United States, 2001 – 2015
Incidence of AIDS-defining Illness by Cancer Status in an Observational Study among Medicaid Beneficiaries Living with HIV in the United States, 2001 – 2015 Open
Background: Malignant neoplasms remain one of the leading morbidities and causes of death among people with HIV (PWH). Prior research suggests that certain cancer treatments may have deleterious effects on the immune system. Setting: We qu…
View article: Incidence of frailty-related fracture among Medicaid beneficiaries living with HIV and cancer: A cohort study
Incidence of frailty-related fracture among Medicaid beneficiaries living with HIV and cancer: A cohort study Open
Background People living with HIV (PLWH) are at increased risk for frailty-related fracture. Limited evidence suggests recent diagnosis of non-AIDS defining cancer (NADC) is a risk factor for fracture among PLWH. We evaluated frailty-relat…
View article: 550 A Cross-Sectional Analysis to Assess the Impact of Digital Consent on Shared Decision-Making Scores, With Regression Analysis to Evaluate the Impact of Perceived Barriers to Digital Adoption
550 A Cross-Sectional Analysis to Assess the Impact of Digital Consent on Shared Decision-Making Scores, With Regression Analysis to Evaluate the Impact of Perceived Barriers to Digital Adoption Open
Aim Shared decision making (SDM) is a GMC requirement of consent. Paper consent forms are not suited to document SDM discussions, e.g. no space for alternative treatment options, whilst digital consent includes these features. Increasing a…
View article: Comparing and integrating human mobility data sources for measles transmission modeling in Zambia
Comparing and integrating human mobility data sources for measles transmission modeling in Zambia Open
Quantifying population mobility is crucial in developing accurate models of infectious disease dynamics. Increasingly, multiple data sources are available to describe individual and population mobility in a single location; however, there …
View article: Impact of race, sex and age on the probability of pancreatic cancer among patients with newly diagnosed diabetes in a claims-based cohort
Impact of race, sex and age on the probability of pancreatic cancer among patients with newly diagnosed diabetes in a claims-based cohort Open
Objective Pancreatic cancer diagnoses are frequently preceded by a new diabetes diagnosis. Screening individuals newly diagnosed with diabetes could enable the earlier detection of pancreatic cancer. We sought to estimate the risk of pancr…
View article: Building the TechHub.training Website for Training Accountants in Data Analytics
Building the TechHub.training Website for Training Accountants in Data Analytics Open
SYNOPSIS We use the design science methodology to develop and validate a website that serves as a free resource for learners to hone their technology skills through meaningful technology experiences, while also providing recognition for th…
View article: Impact of race, sex and age on the probability of pancreatic cancer among patients with newly diagnosed diabetes
Impact of race, sex and age on the probability of pancreatic cancer among patients with newly diagnosed diabetes Open
Background Pancreatic cancer diagnoses are frequently preceded by a new diabetes diagnosis. Screening individuals newly diagnosed with diabetes could enable earlier pancreatic cancer detection. We sought to estimate the risk of pancreatic …
View article: A precision randomized trial to evaluate the impact of tailored hepatitis C treatment adherence support on HCV treatment outcomes among people who inject drugs in India: design and baseline characteristics of the STOP-C trial
A precision randomized trial to evaluate the impact of tailored hepatitis C treatment adherence support on HCV treatment outcomes among people who inject drugs in India: design and baseline characteristics of the STOP-C trial Open
Efforts to eliminate the hepatitis C virus (HCV) as a public health problem must include people who inject drugs (PWID). We describe the design and baseline characteristics of the Supporting Treatment Outcomes among PWID trial, which evalu…
View article: Adjusting mobile phone data to account for children’s travel and the impact on measles dynamics in Zambia
Adjusting mobile phone data to account for children’s travel and the impact on measles dynamics in Zambia Open
Models of measles transmission can be used to identify areas of high risk to tailor immunization strategies. Estimates of spatial connectivity can be derived from data such as mobile phone records, but it is not clear how this maps to the …
View article: Retention in care and antiretroviral therapy adherence among Medicaid beneficiaries with HIV, 2001–2015
Retention in care and antiretroviral therapy adherence among Medicaid beneficiaries with HIV, 2001–2015 Open
Disparities in HIV care by socioeconomic status, place of residence, and race/ethnicity prevent progress toward epidemic control. No study has comprehensively characterized the HIV care cascade among people with HIV enrolled in Medicaid - …
View article: Receipt of Prostate-Specific Antigen Test in Medicaid Beneficiaries With and Without HIV in 2001–2015 in 14 States
Receipt of Prostate-Specific Antigen Test in Medicaid Beneficiaries With and Without HIV in 2001–2015 in 14 States Open
Studies have reported lower incidence of prostate cancer in men living with HIV compared with men without HIV for reasons that remain unclear. Lower prostate cancer screening in men living with HIV could explain these findings. We describe…
View article: Cohort profile: the Johns Hopkins COVID Long Study (JHCLS)—a US nationwide prospective cohort study
Cohort profile: the Johns Hopkins COVID Long Study (JHCLS)—a US nationwide prospective cohort study Open
Purpose COVID-19 continues to affect millions of individuals worldwide, both in the short and long term. The post-acute complications of SARS-CoV-2 infection, referred to as long COVID, result in diverse symptoms affecting multiple organ s…
View article: Incidence of prostate cancer in Medicaid beneficiaries with and without HIV in 2001-2015 in 14 states
Incidence of prostate cancer in Medicaid beneficiaries with and without HIV in 2001-2015 in 14 states Open
Background Prostate cancer is projected to be the most common cancer among people living with HIV; however, incidence of prostate cancer has been reported to be lower in men with HIV compared to men without HIV with little evidence to expl…
View article: Retention in care and antiretroviral therapy adherence among Medicaid beneficiaries with HIV, 2001-2015
Retention in care and antiretroviral therapy adherence among Medicaid beneficiaries with HIV, 2001-2015 Open
Disparities in HIV care by socioeconomic status, place of residence, and race/ethnicity prevent progress toward epidemic control. No study has comprehensively characterized the HIV care cascade among people with HIV enrolled in Medicaid – …
View article: Who is missed in a community-based survey: Assessment and implications of biases due to incomplete sampling frame in a community-based serosurvey, Choma and Ndola Districts, Zambia, 2022
Who is missed in a community-based survey: Assessment and implications of biases due to incomplete sampling frame in a community-based serosurvey, Choma and Ndola Districts, Zambia, 2022 Open
Community-based serological studies are increasingly relied upon to measure disease burden, identify population immunity gaps, and guide control and elimination strategies; however, there is little understanding of the potential for and im…
View article: Incidence of Colon Cancer Among Medicaid Beneficiaries With or Without Human Immunodeficiency Virus Under Comparable Colorectal Cancer Screening Patterns
Incidence of Colon Cancer Among Medicaid Beneficiaries With or Without Human Immunodeficiency Virus Under Comparable Colorectal Cancer Screening Patterns Open
Background People with human immunodeficiency virus (HIV; PWH) in the United States have a lower incidence of colon cancer than the general population. The lower incidence may be explained by differences in receipt of screening. Thus, we s…
View article: Cohort profile: the Johns Hopkins COVID Long Study (JHCLS), a United States Nationwide Prospective Cohort Study
Cohort profile: the Johns Hopkins COVID Long Study (JHCLS), a United States Nationwide Prospective Cohort Study Open
Purpose COVID-19 disease continues to affect millions of individuals worldwide, both in the short and long term. The post-acute complications of SARS-CoV-2 infection, referred to as long COVID, result in diverse symptoms affecting multiple…
View article: Ancillary service needs among persons new to HIV care and the relationship between needs and late presentation to care
Ancillary service needs among persons new to HIV care and the relationship between needs and late presentation to care Open
Ancillary service needs likely influence time to diagnosis and presentation for HIV care. The effect of both met and unmet needs on late presentation to HIV care is not well understood. We used baseline data from 348 people with HIV (PWH) …
View article: Predictors of Longitudinal Trajectories of Alcohol Consumption in People with HIV
Predictors of Longitudinal Trajectories of Alcohol Consumption in People with HIV Open
Background: Our aim was to describe alcohol consumption trajectories in a cohort of people living with HIV and determine clinical and sociodemographic predictors of each trajectory. Methods: This is a prospective cohort study of 7,906 pati…
View article: Comparison of allocation strategies of convalescent plasma to reduce excess infections and mortality from SARS-CoV-2 in a US-like population
Comparison of allocation strategies of convalescent plasma to reduce excess infections and mortality from SARS-CoV-2 in a US-like population Open
Background: While the use of convalescent plasma (CP) in the ongoing COVID-19 pandemic has been inconsistent, CP has the potential to reduce excess morbidity and mortality in future pandemics. Given constraints on CP supply, decisions surr…
View article: Outpatient COVID-19 convalescent plasma recipient antibody thresholds correlated to reduced hospitalizations within a randomized trial
Outpatient COVID-19 convalescent plasma recipient antibody thresholds correlated to reduced hospitalizations within a randomized trial Open
BACKGROUNDCOVID-19 convalescent plasma (CCP) virus-specific antibody levels that translate into recipient posttransfusion antibody levels sufficient to prevent disease progression are not defined.METHODSThis secondary analysis correlated d…
View article: Perspectives on the future of epidemiology: A framework for training
Perspectives on the future of epidemiology: A framework for training Open
Over the past century, the field of epidemiology has evolved and adapted to changing public health needs. Challenges include newly emerging public health concerns across broad and diverse content areas, new methods, and vast data sources. …
View article: Comparing Cancer Incidence in an Observational Cohort of Medicaid Beneficiaries With and Without HIV, 2001–2015
Comparing Cancer Incidence in an Observational Cohort of Medicaid Beneficiaries With and Without HIV, 2001–2015 Open
Background: Life expectancy among people with HIV (PWH) is increasing, making chronic conditions—including cancer—increasingly relevant. Among PWH, cancer burden has shifted from AIDS-defining cancers (ADCs) toward non–AIDS-defining cancer…
View article: Lower endoscopy, early-onset, and average-onset colon cancer among Medicaid beneficiaries with and without HIV
Lower endoscopy, early-onset, and average-onset colon cancer among Medicaid beneficiaries with and without HIV Open
Background: Studies suggest a lower colorectal cancer (CRC) risk and lower or similar CRC screening among people with HIV (PWH) compared with the general population. We evaluated the incidence of lower endoscopy and average-onset (diagnose…
View article: Censoring for loss to follow-up in time-to-event analyses of composite outcomes or in the presence of competing risks
Censoring for loss to follow-up in time-to-event analyses of composite outcomes or in the presence of competing risks Open
Background: In time-to-event analyses, there is limited guidance on when persons who are lost to follow-up (LTFU) should be censored. Methods: We simulated bias in risk estimates for: (1) a composite event of measured (outcome only observa…
View article: Transfusion reactions associated with <scp>COVID</scp>‐19 convalescent plasma in outpatient clinical trials
Transfusion reactions associated with <span>COVID</span>‐19 convalescent plasma in outpatient clinical trials Open
Background COVID‐19 convalescent plasma (CCP) is an important therapeutic option for outpatients at high risk of hospitalization from SARS‐CoV‐2 infection. We assessed the safety of outpatient CCP transfusions administered during clinical …
View article: Case Report: Apical Hypertrophic Cardiomyopathy of an elite athlete in the Hong Kong Sports Institute
Case Report: Apical Hypertrophic Cardiomyopathy of an elite athlete in the Hong Kong Sports Institute Open
This case report is about an elite athlete in the Hong Kong Sports Institute who was diagnosed apical hypertrophic cardiomyopathy through periodic medical assessment with history taking, physical examination, 12-lead resting ECG and subseq…