Benjamin Lebecque
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View article: Evaluating a predictive model of tyrosine kinase inhibitor therapy failure in a European-type cohort: a step towards population-specific tools
Evaluating a predictive model of tyrosine kinase inhibitor therapy failure in a European-type cohort: a step towards population-specific tools Open
Predicting therapeutic failure in patients with chronic phase-chronic myeloid leukemia (CP-CML) treated with tyrosine kinase inhibitors (TKI) remains a major challenge for personalized care management. The Sokal and EUTOS long-term surviva…
View article: Efficacy and safety of azacitidine for VEXAS syndrome: a large-scale retrospective study from FRENVEX
Efficacy and safety of azacitidine for VEXAS syndrome: a large-scale retrospective study from FRENVEX Open
VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a severe monogenic disorder caused by somatic mutations in ubiquitin-like modifier activating enzyme 1 (UBA1), characterized by inflammation, cytopenias, and freq…
View article: Contribution of molecular characterization to the diagnosis of MPN in patients with low JAK2V617F variant allelic fraction in a real-world cohort
Contribution of molecular characterization to the diagnosis of MPN in patients with low JAK2V617F variant allelic fraction in a real-world cohort Open
Since 2008, the JAK2V617F mutation has been key for diagnosing myeloproliferative neoplasms (MPN) according to the World Health Organization criteria. However, the clinical and biological significance of low JAK2V617F…
View article: Correction: Value of combining biological age with assessment of individual frailty to optimize management of cancer treated with targeted therapies: model of chronic myeloid leukemia treated with tyrosine kinase inhibitors (BIO-TIMER trial)
Correction: Value of combining biological age with assessment of individual frailty to optimize management of cancer treated with targeted therapies: model of chronic myeloid leukemia treated with tyrosine kinase inhibitors (BIO-TIMER trial) Open
View article: Value of combining biological age with assessment of individual frailty to optimize management of cancer treated with targeted therapies: model of chronic myeloid leukemia treated with tyrosine kinase inhibitors (BIO-TIMER trial)
Value of combining biological age with assessment of individual frailty to optimize management of cancer treated with targeted therapies: model of chronic myeloid leukemia treated with tyrosine kinase inhibitors (BIO-TIMER trial) Open
View article: Near‐early T‐cell precursor acute lymphoblastic leukemia following a diagnosis of essential thrombocythemia
Near‐early T‐cell precursor acute lymphoblastic leukemia following a diagnosis of essential thrombocythemia Open
A 54-year-old man with a history of essential thrombocythemia (ET) harboring the JAK2V617F mutation (variant allele fraction [VAF], 9.7%) with normal karyotype, initially treated with interferon alpha for 5 years and then with hydroxyurea …
View article: BCOR/BCORL1 mutated hypergranular cells mimicking acute promyelocytic leukemia
BCOR/BCORL1 mutated hypergranular cells mimicking acute promyelocytic leukemia Open
View article: Optical Genome Mapping in Routine Cytogenetic Diagnosis of Acute Leukemia
Optical Genome Mapping in Routine Cytogenetic Diagnosis of Acute Leukemia Open
Cytogenetic aberrations are found in 65% of adults and 75% of children with acute leukemia. Specific aberrations are used as markers for the prognostic stratification of patients. The current standard cytogenetic procedure for acute leukem…
View article: The Spliceosome: A New Therapeutic Target in Chronic Myeloid Leukaemia
The Spliceosome: A New Therapeutic Target in Chronic Myeloid Leukaemia Open
RNA splicing factors are frequently altered in cancer and can act as both oncoproteins and tumour suppressors. They have been found mutated or deregulated, justifying the growing interest in the targeting of splicing catalysis, splicing re…
View article: Deciphering Genetic Alterations of Hairy Cell Leukemia and Hairy Cell Leukemia-like Disorders in 98 Patients
Deciphering Genetic Alterations of Hairy Cell Leukemia and Hairy Cell Leukemia-like Disorders in 98 Patients Open
Hairy cell leukemia (cHCL) patients have, in most cases, a specific clinical and biological presentation with splenomegaly, anemia, leukopenia, neutropenia, monocytopenia and/or thrombocytopenia, identification of hairy cells that express …
View article: Mast cell density and its clinical relevance in Waldenström's macroglobulinemia
Mast cell density and its clinical relevance in Waldenström's macroglobulinemia Open
The presence of numerous mast cells (MCs) mixed with tumor cells in the bone marrow (BM) is a hallmark of the diagnosis of Waldenström's macroglobulinemia (WM). MCs have been shown to support lymphoplasmacytic cell growth, but there is thu…
View article: Hemophagocytosis by acute myeloid leukemia blasts associated to poor clinical outcomes
Hemophagocytosis by acute myeloid leukemia blasts associated to poor clinical outcomes Open
A 74-year-old man was referred to the university hospital for fatigue, weight loss, and thrombocytopenia. Initial examination revealed maculopapular lesions on his body. Subsequent blood tests showed mild normocytic anemia (12.1 g/dL), thr…
View article: Apport du NGS appliqué aux hémopathies myéloïdes en pratique clinique, expérience monocentrique
Apport du NGS appliqué aux hémopathies myéloïdes en pratique clinique, expérience monocentrique Open
View article: DNA Methylation and Intra-Clonal Heterogeneity: The Chronic Myeloid Leukemia Model
DNA Methylation and Intra-Clonal Heterogeneity: The Chronic Myeloid Leukemia Model Open
Chronic Myeloid Leukemia (CML) is a model to investigate the impact of tumor intra-clonal heterogeneity in personalized medicine. Indeed, tyrosine kinase inhibitors (TKIs) target the BCR-ABL fusion protein, which is considered the major CM…
View article: Efficiency of nilotinib to target chronic phase-chronic myeloid leukaemia primary mature CD34− and immature CD34+ cells
Efficiency of nilotinib to target chronic phase-chronic myeloid leukaemia primary mature CD34− and immature CD34+ cells Open
View article: Chronic myelomonocytic leukaemia followed by blastic plasmacytoid dendritic cell neoplasm
Chronic myelomonocytic leukaemia followed by blastic plasmacytoid dendritic cell neoplasm Open
A 74-year-old patient was hospitalised for the investigation of generalised lymphadenopathy and cutaneous manifestations (red and inflammatory nodules, erythema in 12 different localizations) 2 years after a diagnosis of chronic myelomonoc…
View article: B & B: basophils and bleeding, an atypical case of acute promyelocytic leukemia
B & B: basophils and bleeding, an atypical case of acute promyelocytic leukemia Open
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A 59-year-old woman was hospitalized for investigation of spontaneous bruises on arms and legs and asthenia. Complete blood count and blood smear review showed pancytopenia (platelets 78 × 109/L, hemoglobin concentration 10.…