Benjamin Liechty
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View article: Clinical Utility of [F18]-Fluciclovine PET/MRI for Differentiating True Progression from Treatment-Related Changes in Patients with Glioblastoma
Clinical Utility of [F18]-Fluciclovine PET/MRI for Differentiating True Progression from Treatment-Related Changes in Patients with Glioblastoma Open
[F18]-FACBC and [F18]-Fluciclovine＝ Trans-1-amino-3-[F18]-fluorocyclobutane-1-carboxylic acid; GBM＝glioblastoma; IDH＝Isocitrate Dehydrogenase; SUVmax＝maximum standardized uptake value.
View article: Yttrium-90 radioembolization for treatment of anaplastic meningioma liver metastases
Yttrium-90 radioembolization for treatment of anaplastic meningioma liver metastases Open
Meningiomas are the most common primary intracranial neoplasm. The WHO classification, focusing on histomorphologic and molecular features, distinguishes WHO grade -1, -2, and -3 tumors. WHO-3 meningiomas are exceedingly rare, comprising 1…
View article: IMG-63. Clinical Utility of 18F-FLUCICLOVINE PET/MRI for Differentiating True Progression from Treatment Effects in Glioblastoma
IMG-63. Clinical Utility of 18F-FLUCICLOVINE PET/MRI for Differentiating True Progression from Treatment Effects in Glioblastoma Open
INTRODUCTION 18F-FLUCICLOVINE (Axumin), an amino acid analog PET radiotracer, FDA approved for recurrent prostate cancer evaluation, is increasingly being applied in neuro-oncology. Differentiating true glioblastoma (GBM) progression from …
View article: Long-Term Outcomes of Active Surveillance After DOTATATE PET/MRI–Confirmed Gross Total Resection in WHO Grade 2 Meningioma
Long-Term Outcomes of Active Surveillance After DOTATATE PET/MRI–Confirmed Gross Total Resection in WHO Grade 2 Meningioma Open
Background Somatostatin receptor 2 (SSTR2), a highly sensitive and specific meningioma biomarker, can be imaged with [68Ga]-DOTATATE PET, improving diagnosis and treatment. The role of postoperative radiotherapy (RT) for WHO grade 2 (WHO-2…
View article: Glo-VLMs: Leveraging Vision-Language Models for Fine-Grained Diseased Glomerulus Classification
Glo-VLMs: Leveraging Vision-Language Models for Fine-Grained Diseased Glomerulus Classification Open
Vision-language models (VLMs) have shown considerable potential in digital pathology, yet their effectiveness remains limited for fine-grained, disease-specific classification tasks such as distinguishing between glomerular subtypes. The s…
View article: Cancer type, stage and prognosis assessment from pathology reports using LLMs
Cancer type, stage and prognosis assessment from pathology reports using LLMs Open
View article: Preoperative PET/MRI and radio-guided surgery using [Cu64]DOTATATE in meningioma: a feasibility study. Illustrative case
Preoperative PET/MRI and radio-guided surgery using [Cu64]DOTATATE in meningioma: a feasibility study. Illustrative case Open
BACKGROUND Meningiomas are the most common primary intracranial neoplasms. Gross-total resection, the primary treatment goal, is not achieved in up to 50% of patients, affecting progression-free and overall survival. The traditionally used…
View article: Cancer Type, Stage and Prognosis Assessment from Pathology Reports using LLMs
Cancer Type, Stage and Prognosis Assessment from Pathology Reports using LLMs Open
Large Language Models (LLMs) have shown significant promise across various natural language processing tasks. However, their application in the field of pathology, particularly for extracting meaningful insights from unstructured medical t…
View article: CASC-AI: Consensus-aware Self-corrective Learning for Noise Cell Segmentation
CASC-AI: Consensus-aware Self-corrective Learning for Noise Cell Segmentation Open
Multi-class cell segmentation in high-resolution gigapixel whole slide images (WSIs) is crucial for various clinical applications. However, training such models typically requires labor-intensive, pixel-wise annotations by domain experts. …
View article: Long-Term Outcomes of Active Surveillance after DOTATATE PET/MRI–Confirmed Gross Total Resection in WHO Grade 2 Meningioma
Long-Term Outcomes of Active Surveillance after DOTATATE PET/MRI–Confirmed Gross Total Resection in WHO Grade 2 Meningioma Open
View article: Evaluation of the rapid Idylla IDH1-2 mutation assay in FFPE glioma samples
Evaluation of the rapid Idylla IDH1-2 mutation assay in FFPE glioma samples Open
IDH1 and IDH2 mutational status is a critical biomarker with diagnostic, prognostic, and treatment implications in glioma. Although IDH1 p.R132H-specific immunohistochemistry is available, it is unable to identify other mutations in IDH1/2…
View article: DOTATATE PET/MR Imaging Differentiates Secondary-Progressive from de Novo World Health Organization Grade 3 Meningiomas
DOTATATE PET/MR Imaging Differentiates Secondary-Progressive from de Novo World Health Organization Grade 3 Meningiomas Open
Our study confirms prior work illustrating distinct clinical outcomes in secondary-progressive and de novo World Health Organization grade 3 meningiomas. Furthermore, our findings support (68Ga) DOTATATE PET/MR imaging as a usef…
View article: Chronic hypoxia remodels the tumor microenvironment to support glioma stem cell growth
Chronic hypoxia remodels the tumor microenvironment to support glioma stem cell growth Open
Cerebral organoids co-cultured with patient derived glioma stem cells (GLICOs) are an experimentally tractable research tool useful for investigating the role of the human brain tumor microenvironment in glioblastoma. Here we describe long…
View article: Data from Impact of Rare and Multiple Concurrent Gene Fusions on Diagnostic DNA Methylation Classifier in Brain Tumors
Data from Impact of Rare and Multiple Concurrent Gene Fusions on Diagnostic DNA Methylation Classifier in Brain Tumors Open
DNA methylation is an essential molecular assay for central nervous system (CNS) tumor diagnostics. While some fusions define specific brain tumors, others occur across many different diagnoses. We performed a retrospective analysis of 219…
View article: Supplementary Table 2 from Impact of Rare and Multiple Concurrent Gene Fusions on Diagnostic DNA Methylation Classifier in Brain Tumors
Supplementary Table 2 from Impact of Rare and Multiple Concurrent Gene Fusions on Diagnostic DNA Methylation Classifier in Brain Tumors Open
List of all gene fusions and associated DNA methylation classes and scores
View article: Supplementary Table 2 from Impact of Rare and Multiple Concurrent Gene Fusions on Diagnostic DNA Methylation Classifier in Brain Tumors
Supplementary Table 2 from Impact of Rare and Multiple Concurrent Gene Fusions on Diagnostic DNA Methylation Classifier in Brain Tumors Open
List of all gene fusions and associated DNA methylation classes and scores
View article: Supplementary Table 1 from Impact of Rare and Multiple Concurrent Gene Fusions on Diagnostic DNA Methylation Classifier in Brain Tumors
Supplementary Table 1 from Impact of Rare and Multiple Concurrent Gene Fusions on Diagnostic DNA Methylation Classifier in Brain Tumors Open
List of genes in the fusion panels
View article: Supplementary Table 1 from Impact of Rare and Multiple Concurrent Gene Fusions on Diagnostic DNA Methylation Classifier in Brain Tumors
Supplementary Table 1 from Impact of Rare and Multiple Concurrent Gene Fusions on Diagnostic DNA Methylation Classifier in Brain Tumors Open
List of genes in the fusion panels
View article: Data from Impact of Rare and Multiple Concurrent Gene Fusions on Diagnostic DNA Methylation Classifier in Brain Tumors
Data from Impact of Rare and Multiple Concurrent Gene Fusions on Diagnostic DNA Methylation Classifier in Brain Tumors Open
DNA methylation is an essential molecular assay for central nervous system (CNS) tumor diagnostics. While some fusions define specific brain tumors, others occur across many different diagnoses. We performed a retrospective analysis of 219…
View article: Cerebral Amyloid Angiopathy-Related Inflammation Presenting as Nontraumatic Subdural Hematoma
Cerebral Amyloid Angiopathy-Related Inflammation Presenting as Nontraumatic Subdural Hematoma Open
A 77-year-old woman presented with headache and confusion. Computed tomography of the head demonstrated an acute left falcine and tentorial subdural hemorrhage. Magnetic resonance imaging of the brain additionally showed sulcal hyperintens…
View article: Polymorphous low-grade neuroepithelial tumor of the young with FGFR3-TACC3 fusion mimicking high-grade glioma: case report and series of high-grade correlates
Polymorphous low-grade neuroepithelial tumor of the young with FGFR3-TACC3 fusion mimicking high-grade glioma: case report and series of high-grade correlates Open
Background Polymorphous low-grade neuroepithelial tumor of the young (PLNTY) is a recently described entity that can mimic high-grade glioma (HGG) in histologic and molecular features; however, factors predicting aggressive behavior in the…
View article: NIMG-73. RADIOGRAPHIC CHANGES AFTER RADIATION THERAPY IN SUBTOTALLY RESECTED ATYPICAL MENINGIOMAS
NIMG-73. RADIOGRAPHIC CHANGES AFTER RADIATION THERAPY IN SUBTOTALLY RESECTED ATYPICAL MENINGIOMAS Open
BACKGROUND Adjuvant radiotherapy (RT) has been shown to improve outcomes after subtotal resection (STR) of atypical meningioma, but little is known about how tumors evolve on magnetic resonance imaging (MRI) and whether this correlates wit…
View article: Impact of Rare and Multiple Concurrent Gene Fusions on Diagnostic DNA Methylation Classifier in Brain Tumors
Impact of Rare and Multiple Concurrent Gene Fusions on Diagnostic DNA Methylation Classifier in Brain Tumors Open
DNA methylation is an essential molecular assay for central nervous system (CNS) tumor diagnostics. While some fusions define specific brain tumors, others occur across many different diagnoses. We performed a retrospective analysis of 219…
View article: Characterizing the Features of Mitotic Figures Using a Conditional Diffusion Probabilistic Model
Characterizing the Features of Mitotic Figures Using a Conditional Diffusion Probabilistic Model Open
Mitotic figure detection in histology images is a hard-to-define, yet clinically significant task, where labels are generated with pathologist interpretations and where there is no ``gold-standard'' independent ground-truth. However, it is…
View article: The importance of escalating molecular diagnostics in patients with low-grade pediatric brain cancer
The importance of escalating molecular diagnostics in patients with low-grade pediatric brain cancer Open
Pilocytic astrocytomas are the most common pediatric brain tumors, typically presenting as low-grade neoplasms. We report two cases of pilocytic astrocytoma with atypical tumor progression. Case 1 involves a 12-yr-old boy with an unresecta…
View article: 327 Radiopathomics: Integration of Advanced Neuroimaging and Molecular Pathology Features in Meningiomas
327 Radiopathomics: Integration of Advanced Neuroimaging and Molecular Pathology Features in Meningiomas Open
OBJECTIVES/GOALS: Our overall objective is to investigate the relationship between radiologic features of meningioma with recently identified histopathological and molecular biomarkers, and to apply a machine learning (ML) approach to furt…
View article: Clinical utility of whole-genome DNA methylation profiling as a primary molecular diagnostic assay for central nervous system tumors—A prospective study and guidelines for clinical testing
Clinical utility of whole-genome DNA methylation profiling as a primary molecular diagnostic assay for central nervous system tumors—A prospective study and guidelines for clinical testing Open
Background Central nervous system (CNS) cancer is the 10th leading cause of cancer-associated deaths for adults, but the leading cause in pediatric patients and young adults. The variety and complexity of histologic subtypes can lead to di…
View article: Machine learning can aid in prediction of IDH mutation from H&E-stained histology slides in infiltrating gliomas
Machine learning can aid in prediction of IDH mutation from H&E-stained histology slides in infiltrating gliomas Open
View article: Towards a single-assay approach: a combined DNA/RNA sequencing panel eliminates diagnostic redundancy and detects clinically-relevant fusions in neuropathology
Towards a single-assay approach: a combined DNA/RNA sequencing panel eliminates diagnostic redundancy and detects clinically-relevant fusions in neuropathology Open
View article: NIMG-91. DOTATATE PET/MR-GUIDED POSTOPERATIVE MANAGEMENT IN WHO-2 MENINGIOMA: ACTIVE SURVEILLANCE BASED ON PET/MR EVIDENCE OF GROSS TOTAL RESECTION
NIMG-91. DOTATATE PET/MR-GUIDED POSTOPERATIVE MANAGEMENT IN WHO-2 MENINGIOMA: ACTIVE SURVEILLANCE BASED ON PET/MR EVIDENCE OF GROSS TOTAL RESECTION Open
BACKGROUND MRI, the standard of care (SOC) for meningioma radiotherapy planning, lacks sensitivity for postoperative small volume disease and osseous or parenchymal invasion. BN003 (NCT03180268) randomizes patients with WHO-2 meningiomas a…