Benjamin M. Brainard
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View article: Correction: Anticoagulant therapy and altered tissue factor expression protect against experimental placental and cerebral malaria
Correction: Anticoagulant therapy and altered tissue factor expression protect against experimental placental and cerebral malaria Open
[This corrects the article DOI: 10.1371/journal.ppat.1013259.].
View article: A Prospective Multicenter Observational Study Assessing Incidence and Risk Factors for Acute Transfusion Reactions in Cats
A Prospective Multicenter Observational Study Assessing Incidence and Risk Factors for Acute Transfusion Reactions in Cats Open
Background The reported incidence of blood product transfusion reaction (TR) in cats varies greatly. Objective Evaluate the incidence and practices surrounding acute TRs in cats receiving feline blood products, using Transfusion Reaction S…
View article: Anticoagulant therapy and altered tissue factor expression protect against experimental placental and cerebral malaria
Anticoagulant therapy and altered tissue factor expression protect against experimental placental and cerebral malaria Open
Severe malaria remains a major public health concern in regions of moderate to high Plasmodium falciparum transmission. Women and young children are especially vulnerable to two clinical manifestations of severe P. falciparum malaria, know…
View article: Associations Among Various Physical Parameters and the Axillary‐to‐Rectal Temperature Difference in Dogs and Cats
Associations Among Various Physical Parameters and the Axillary‐to‐Rectal Temperature Difference in Dogs and Cats Open
Objective To compare the measurement of axillary temperature (AT) with rectal temperature (RT) in dogs and cats and to identify the influence of physical parameters on the difference between their measurement using a veterinary‐specific th…
View article: Characteristics of Low‐Speed Vehicular Rollover Trauma in Dogs Presenting to an Emergency Service at a Veterinary Teaching Hospital
Characteristics of Low‐Speed Vehicular Rollover Trauma in Dogs Presenting to an Emergency Service at a Veterinary Teaching Hospital Open
Objective To describe the epidemiology of, and injuries associated with, low‐ versus higher‐speed vehicular trauma and to identify risk factors associated with mortality. Design Retrospective study from January 2015 to November 2020. Setti…
View article: Therapy with clopidogrel or rivaroxaban has equivalent impacts on recurrence of thromboembolism and survival in cats following cardiogenic thromboembolism: the SUPERCAT study
Therapy with clopidogrel or rivaroxaban has equivalent impacts on recurrence of thromboembolism and survival in cats following cardiogenic thromboembolism: the SUPERCAT study Open
OBJECTIVE To assess the impact of clopidogrel or rivaroxaban administration on recurrence of arterial thromboembolism (ATE) in cats that have recovered from cardiogenic ATE. METHODS This multicenter prospective double-masked protocol enrol…
View article: Editorial: Best practices in clinical research conduct in veterinary medicine
Editorial: Best practices in clinical research conduct in veterinary medicine Open
View article: Poster: A Contactless Health Monitoring System for Humans and Animals
Poster: A Contactless Health Monitoring System for Humans and Animals Open
Health monitoring is essential for both humans and animals in daily life. While numerous health monitoring systems have been developed, the majority are designed exclusively for either humans or animals, and most require direct physical co…
View article: A prospective multicenter observational study assessing incidence and risk factors for acute blood transfusion reactions in dogs
A prospective multicenter observational study assessing incidence and risk factors for acute blood transfusion reactions in dogs Open
Background Reported incidence of blood transfusion reactions (TR) varies greatly. Objective To prospectively evaluate the incidence of acute TRs in dogs receiving allogenic blood products, using consensus definitions, and to assess factors…
View article: 2024 RECOVER Guidelines: Updated treatment recommendations for CPR in dogs and cats
2024 RECOVER Guidelines: Updated treatment recommendations for CPR in dogs and cats Open
Objective After the 2012 Reassessment Campaign on Veterinary Resuscitation (RECOVER) CPR Guidelines, this is an update of evidence‐based consensus guidelines for Basic Life Support (BLS), advanced life support (ALS), and periarrest monitor…
View article: 2024 RECOVER Guidelines: Monitoring. Evidence and knowledge gap analysis with treatment recommendations for small animal CPR
2024 RECOVER Guidelines: Monitoring. Evidence and knowledge gap analysis with treatment recommendations for small animal CPR Open
Objective To systematically review evidence on and devise treatment recommendations for patient monitoring before, during, and following CPR in dogs and cats, and to identify critical knowledge gaps. Design Standardized, systematic evaluat…
View article: Treatment of Coagulation and Platelet Disorders
Treatment of Coagulation and Platelet Disorders Open
Interest in the process of both normal and disordered hemostasis in the veterinary patient has increased in recent years due in part to the availability of newer tests and techniques that can better illustrate the process and products of c…
View article: Evaluation of darbepoetin therapy on platelet count and function in healthy cats and cats with surgically induced chronic kidney disease
Evaluation of darbepoetin therapy on platelet count and function in healthy cats and cats with surgically induced chronic kidney disease Open
OBJECTIVE To evaluate the effects of darbepoetin on platelet population and reactivity in healthy cats (HCs) and azotemic cats with remnant kidney (RK) model–induced chronic kidney disease. ANIMALS 12 purpose-bred domestic shorthair cats (…
View article: Evaluation of activation characteristics of a canine platelet concentrate produced by a commercial double centrifugation system
Evaluation of activation characteristics of a canine platelet concentrate produced by a commercial double centrifugation system Open
Introduction In veterinary medicine there are few readily available products for platelet transfusion to patients with thrombocytopenia. Commercial tabletop platelet concentrating systems have recently become available to veterinarians, pr…
View article: <scp>ACVIM</scp> consensus statement on the treatment of immune thrombocytopenia in dogs and cats
<span>ACVIM</span> consensus statement on the treatment of immune thrombocytopenia in dogs and cats Open
Management of immune thrombocytopenia (ITP) in dogs and cats is evolving, but there are no evidence‐based guidelines to assist clinicians with treatment decisions. Likewise, the overall goals for treatment of ITP have not been established.…
View article: Evaluation of coagulation and platelet activation state and function in heartworm‐infected dogs
Evaluation of coagulation and platelet activation state and function in heartworm‐infected dogs Open
Background Enhanced platelet responses have been demonstrated in heartworm‐infected (HWI) dogs; however, the cause and clinical implications of altered platelet function have not been fully elucidated. Objective This study evaluated platel…
View article: Performance evaluation of a Test&Treat rapid detection kit for the diagnosis of septic effusions in dogs and cats
Performance evaluation of a Test&Treat rapid detection kit for the diagnosis of septic effusions in dogs and cats Open
Objective To evaluate the sensitivity and specificity of a veterinary point‐of‐care (POC) luminometer‐based kit for the diagnosis of septic peritoneal or pleural effusion in dogs and cats. Design Prospective study performed between January…
View article: The sodium correction factor for dogs undergoing treatment for a hyperglycemic crisis is a 1.6-mEq/L decrease in sodium per 100-mg/dL increase in glucose
The sodium correction factor for dogs undergoing treatment for a hyperglycemic crisis is a 1.6-mEq/L decrease in sodium per 100-mg/dL increase in glucose Open
OBJECTIVE To determine the sodium correction factor for clinical use in hyperglycemic diabetic dogs. SAMPLE Retrospective analysis of 76 hospitalization episodes from 67 different dogs presenting to the University of Georgia Veterinary Tea…
View article: Point-of-care and traditional erythrocyte sedimentation rate, point-of-care rheometry, and cell-free DNA concentration in dogs with or without systemic inflammation
Point-of-care and traditional erythrocyte sedimentation rate, point-of-care rheometry, and cell-free DNA concentration in dogs with or without systemic inflammation Open
RBC aggregation and deformability characteristics are altered by inflammatory, microcirculatory, and hemorheologic disease. These changes can be indirectly evaluated using the erythrocyte sedimentation rate (ESR). Newer point-of-care devic…
View article: Effects of orally administered pimobendan on platelet function in healthy adult cats
Effects of orally administered pimobendan on platelet function in healthy adult cats Open
OBJECTIVE Several phosphodiesterase inhibitors have demonstrable antiplatelet actions when administered to human patients. Concentration-dependent inhibition of feline platelet aggregation by pimobendan has been previously demonstrated in …
View article: 2022 Update of the Consensus on the Rational Use of Antithrombotics and Thrombolytics in Veterinary Critical Care (CURATIVE) Domain 6: Defining rational use of thrombolytics
2022 Update of the Consensus on the Rational Use of Antithrombotics and Thrombolytics in Veterinary Critical Care (CURATIVE) Domain 6: Defining rational use of thrombolytics Open
Objectives To systematically review available evidence and establish guidelines related to the use of thrombolytics for the management of small animals with suspected or confirmed thrombosis. Design PICO (Population, Intervention, Control,…
View article: 2022 Update of the Consensus on the Rational Use of Antithrombotics and Thrombolytics in Veterinary Critical Care (CURATIVE) Domain 1‐ Defining populations at risk
2022 Update of the Consensus on the Rational Use of Antithrombotics and Thrombolytics in Veterinary Critical Care (CURATIVE) Domain 1‐ Defining populations at risk Open
Objectives To expand the number of conditions and interventions explored for their associations with thrombosis in the veterinary literature and to provide the basis for prescribing recommendations. Design A population exposure comparison …
View article: Evaluation of the i-STAT Alinity v in a veterinary clinical setting
Evaluation of the i-STAT Alinity v in a veterinary clinical setting Open
Many point-of-care (POC) analyzers are available for the measurement of electrolytes and acid-base status in animals. We assessed the precision of the i-STAT Alinity v, a recently introduced POC analyzer, and compared it to 2 commonly used…
View article: Platelet number and function in response to a single intravenous dose of vincristine
Platelet number and function in response to a single intravenous dose of vincristine Open
Background Vincristine might increase circulating platelet numbers but the functional capacity of these newly released platelets is unknown. Objective To evaluate and compare the functionality of mature and immature (reticulated) platelets…
View article: Intravenous Fluid Administration and the Coagulation System
Intravenous Fluid Administration and the Coagulation System Open
Intravenous fluid administration in veterinary patients can alter coagulation function by several mechanisms. Both crystalloid and colloid fluids cause hemodilution, reducing platelet count and plasma coagulation protein concentrations. He…
View article: Effects of a perioperative antibiotic and veterinary probiotic on fecal dysbiosis index in dogs.
Effects of a perioperative antibiotic and veterinary probiotic on fecal dysbiosis index in dogs. Open
Although widely used, the effects of perioperative antibiotics on the gastrointestinal microbiome are still being researched. The role of probiotics to ameliorate adverse effects of perioperative antibiotics is unclear. The dysbiosis index…
View article: Significant differences in single-platelet biophysics exist across species but attenuate during clot formation
Significant differences in single-platelet biophysics exist across species but attenuate during clot formation Open
Key Points Human, canine, ovine, and porcine platelets exhibit disparate biophysical signatures, whereas human and murine platelets are similar. Multiple biophysical parameters integrate during clot formation, measured by bulk clot contrac…
View article: Author response for "The pharmacokinetics of a fentanyl matrix patch applied at three different anatomical locations in horses"
Author response for "The pharmacokinetics of a fentanyl matrix patch applied at three different anatomical locations in horses" Open
View article: Author response for "The pharmacokinetics of a fentanyl matrix patch applied at three different anatomical locations in horses"
Author response for "The pharmacokinetics of a fentanyl matrix patch applied at three different anatomical locations in horses" Open
View article: Lyophilized platelets versus cryopreserved platelets for management of bleeding in thrombocytopenic dogs: A multicenter randomized clinical trial
Lyophilized platelets versus cryopreserved platelets for management of bleeding in thrombocytopenic dogs: A multicenter randomized clinical trial Open
Background Thrombocytopenia in dogs is common in critical care medicine, but availability of fresh platelet concentrates in veterinary medicine can be limiting. Lyophilized platelets have long shelf‐lives and can be easily transported, sto…