Benjamin M. Scirica
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View article: Semaglutide and cardiovascular outcomes by baseline and changes in adiposity measurements: a prespecified analysis of the SELECT trial
Semaglutide and cardiovascular outcomes by baseline and changes in adiposity measurements: a prespecified analysis of the SELECT trial Open
Novo Nordisk.
View article: Manual vs AI-Assisted Prescreening for Trial Eligibility Using Large Language Models—A Randomized Clinical Trial
Manual vs AI-Assisted Prescreening for Trial Eligibility Using Large Language Models—A Randomized Clinical Trial Open
This randomized clinical trial compares the efficiency of prescreening patients with heart failure using an artificial intelligence (AI) large language model for inclusion in a clinical trial vs manual prescreening.
View article: Continual Versus Occasional Blood Pressure (COOL-BP) in Remote Hypertension Management
Continual Versus Occasional Blood Pressure (COOL-BP) in Remote Hypertension Management Open
BACKGROUND Remote hypertension management programs have emerged as potential solutions to improve poor rates of blood pressure (BP) control. The Continual Versus Occasional Blood Pressure (COOL-BP) Study investigated the feasibility and ef…
View article: Contemporary treatment patterns of overweight and obesity: insights from the Mass General Brigham health care system
Contemporary treatment patterns of overweight and obesity: insights from the Mass General Brigham health care system Open
Objective The objective of this study was to describe the prevalence of obesity, obesity‐related conditions (ORCs), and antiobesity medication (AOM) eligibility and prescribing practice among eligible patients in a large health care system…
View article: Detection of hypertrophic cardiomyopathy on electrocardiogram using artificial intelligence
Detection of hypertrophic cardiomyopathy on electrocardiogram using artificial intelligence Open
Background Hypertrophic cardiomyopathy (HCM) is associated with significant morbidity and mortality including sudden cardiac death in the young. Its prevalence is estimated to be 1 in 500, although many people are undiagnosed. The ability …
View article: Semaglutide and Cardiovascular Outcomes by Baseline HbA1c and Change in HbA1c in People With Overweight or Obesity but Without Diabetes in SELECT
Semaglutide and Cardiovascular Outcomes by Baseline HbA1c and Change in HbA1c in People With Overweight or Obesity but Without Diabetes in SELECT Open
OBJECTIVE To evaluate the cardiovascular effects of semaglutide by baseline glycated hemoglobin (HbA1c) and change in HbA1c in a prespecified analysis of Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity (…
View article: Semaglutide and Cardiovascular Outcomes by Baseline and Change in HbA1c in People With Overweight or Obesity but Without Diabetes in SELECT
Semaglutide and Cardiovascular Outcomes by Baseline and Change in HbA1c in People With Overweight or Obesity but Without Diabetes in SELECT Open
OBJECTIVE To evaluate the cardiovascular (CV) effects of semaglutide by baseline and change in HbA1c in a prespecified analysis of SELECT. RESEARCH DESIGN AND METHODS In SELECT, people with overweight/obesity and atherosclerotic CV disease…
View article: Semaglutide and Cardiovascular Outcomes by Baseline and Change in HbA1c in People With Overweight or Obesity but Without Diabetes in SELECT
Semaglutide and Cardiovascular Outcomes by Baseline and Change in HbA1c in People With Overweight or Obesity but Without Diabetes in SELECT Open
OBJECTIVE To evaluate the cardiovascular (CV) effects of semaglutide by baseline and change in HbA1c in a prespecified analysis of SELECT. RESEARCH DESIGN AND METHODS In SELECT, people with overweight/obesity and atherosclerotic CV disease…
View article: Retrieval-Augmented Generation–Enabled GPT-4 for Clinical Trial Screening
Retrieval-Augmented Generation–Enabled GPT-4 for Clinical Trial Screening Open
BackgroundScreening participants in clinical trials is an error-prone and labor-intensive process that requires significant time and resources. Large language models such as generative pretrained transformer 4 (GPT-4) present an opportunit…
View article: Novel Polygenic Risk Score and Established Clinical Risk Factors for Risk Estimation of Aortic Stenosis
Novel Polygenic Risk Score and Established Clinical Risk Factors for Risk Estimation of Aortic Stenosis Open
Importance Polygenic risk scores (PRSs) have proven to be as strong as or stronger than established clinical risk factors for many cardiovascular phenotypes. Whether this is true for aortic stenosis remains unknown. Objective To develop a …
View article: Lipoprotein(a), C-Reactive Protein, and Cardiovascular Risk in Primary and Secondary Prevention Populations
Lipoprotein(a), C-Reactive Protein, and Cardiovascular Risk in Primary and Secondary Prevention Populations Open
Importance Elevated lipoprotein(a) (Lp[a]) is a putative causal risk factor for atherosclerotic cardiovascular disease (ASCVD). There are conflicting data as to whether Lp(a) may increase cardiovascular risk only in the presence of concomi…
View article: Retrieval Augmented Generation Enabled Generative Pre-Trained Transformer 4 (GPT-4) Performance for Clinical Trial Screening
Retrieval Augmented Generation Enabled Generative Pre-Trained Transformer 4 (GPT-4) Performance for Clinical Trial Screening Open
Background Subject screening is a key aspect of all clinical trials; however, traditionally, it is a labor-intensive and error-prone task, demanding significant time and resources. With the advent of large language models (LLMs) and relate…
View article: Methods, rationale, and design for a remote pharmacist and navigator-driven disease management program to improve guideline-directed medical therapy in patients with type 2 diabetes at elevated cardiovascular and/or kidney risk
Methods, rationale, and design for a remote pharmacist and navigator-driven disease management program to improve guideline-directed medical therapy in patients with type 2 diabetes at elevated cardiovascular and/or kidney risk Open
We are testing a remote, navigator-driven, pharmacist-led, and physician-overseen management strategy to optimize GDMT for T2D as a population-level strategy to close the gap between guidelines and clinical practice for patients with T2D a…
View article: Enrollment strategies in the era of digital revolution: Experience from a remote health management program (Preprint)
Enrollment strategies in the era of digital revolution: Experience from a remote health management program (Preprint) Open
BACKGROUND Remote or decentralized clinical studies allow innovative outreach opportunities, but whether that will result in improved enrollment remains unknown. OBJECTIVE We report our experience in identifying potential participants f…
View article: Formative Perceptions of a Digital Pill System to Measure Adherence to Heart Failure Pharmacotherapy: Mixed Methods Study
Formative Perceptions of a Digital Pill System to Measure Adherence to Heart Failure Pharmacotherapy: Mixed Methods Study Open
Background Heart failure (HF) affects 6.2 million Americans and is a leading cause of hospitalization. The mainstay of the management of HF is adherence to pharmacotherapy. Despite the effectiveness of HF pharmacotherapy, effectiveness is …
View article: Natriuretic peptides, body mass index and heart failure risk: Pooled analyses of <scp>SAVOR‐TIMI</scp> 53, <scp>DECLARE‐TIMI</scp> 58 and <scp>CAMELLIA‐TIMI</scp> 61
Natriuretic peptides, body mass index and heart failure risk: Pooled analyses of <span>SAVOR‐TIMI</span> 53, <span>DECLARE‐TIMI</span> 58 and <span>CAMELLIA‐TIMI</span> 61 Open
Aim N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) concentrations are lower in patients with obesity. The interaction between body mass index (BMI) and NT‐proBNP with respect to heart failure risk remains incompletely defined. Metho…
View article: Implementation of a Scalable Online Weight Management Programme in Clinical Settings: Protocol for the PROPS 2.0 Programme (Partnerships for Reducing Overweight and Obesity with Patient-Centered Strategies 2.0)
Implementation of a Scalable Online Weight Management Programme in Clinical Settings: Protocol for the PROPS 2.0 Programme (Partnerships for Reducing Overweight and Obesity with Patient-Centered Strategies 2.0) Open
Introduction There is an urgent need for scalable strategies for treating overweight and obesity in clinical settings. PROPS 2.0 (Partnerships for Reducing Overweight and Obesity with Patient-Centered Strategies 2.0) aims to adapt and impl…
View article: Quantitative and radiological assessment of post-cardiac arrest comatose patients with diffusion-weighted magnetic resonance imaging
Quantitative and radiological assessment of post-cardiac arrest comatose patients with diffusion-weighted magnetic resonance imaging Open
Background Although MR imaging, particularly diffusion weighted imaging, has increasingly been utilized as part of a multimodal approach to prognostication in patients comatose after cardiac arrest, the performance of quantitative analysis…
View article: Lipoprotein(a) and the risk of major adverse limb events in patients with stable atherosclerotic vascular disease
Lipoprotein(a) and the risk of major adverse limb events in patients with stable atherosclerotic vascular disease Open
Background/Introduction Patients with atherosclerotic vascular disease are at heightened risk of ischemic events, including adverse limb events. The pathobiology of adverse limb events ranges from events that are predominantly thrombotic s…
View article: Risk Assessment of Kidney Disease Progression and Efficacy of SGLT2 Inhibition in Patients With Type 2 Diabetes
Risk Assessment of Kidney Disease Progression and Efficacy of SGLT2 Inhibition in Patients With Type 2 Diabetes Open
OBJECTIVE To develop a risk assessment tool to identify patients with type 2 diabetes (T2D) at higher risk for kidney disease progression and who might benefit more from sodium–glucose cotransporter 2 (SGLT2) inhibition. RESEARCH DESIGN AN…