Benjamin Nicholson
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View article: Identification of a stem cell-specific secretory immune regulatory ligand 3092
Identification of a stem cell-specific secretory immune regulatory ligand 3092 Open
Description Immunotherapies have revolutionized cancer treatment, yet subsets of patients with squamous cell carcinomas (SCCs) experience relapse. Recent research highlighted the roles of a group of tumor-initiating cells (TICs) in driving…
View article: SOX2-driven enhancer landscape defines the transcriptional architecture of retinogenesis
SOX2-driven enhancer landscape defines the transcriptional architecture of retinogenesis Open
Retinal neurogenesis is mediated by the coordinated activities of a complex gene regulatory network (GRN) of transcription factors (TFs) in multipotent retinal progenitor cells (RPCs). How this GRN mechanistically guides neural competence …
View article: Tumor-Initiating Cells Fine-tune the Plasticity of Neutrophils to Sculpt a Protective Niche
Tumor-Initiating Cells Fine-tune the Plasticity of Neutrophils to Sculpt a Protective Niche Open
The abundant accumulation of neutrophils in various solid cancers has been well recognized, but the functions of tumor-associated neutrophils (TANs) remain controversial. TANs have long been believed to be immune suppressive and have thus …
View article: XTX101, a tumor-activated, Fc-enhanced anti-CTLA-4 monoclonal antibody, demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer
XTX101, a tumor-activated, Fc-enhanced anti-CTLA-4 monoclonal antibody, demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer Open
Introduction The clinical benefit of the anti-CTLA-4 monoclonal antibody (mAb) ipilimumab has been well established but limited by immune-related adverse events, especially when ipilimumab is used in combination with anti-PD-(L)1 mAb thera…
View article: 1056 XTX301, a tumor activated, half-life extended IL-12 promoted potent anti-tumor immunity and activity across multiple syngeneic tumor models
1056 XTX301, a tumor activated, half-life extended IL-12 promoted potent anti-tumor immunity and activity across multiple syngeneic tumor models Open
Background Interleukin-12 (IL-12) is a proinflammatory cytokine that bridges innate and adaptive immunity by stimulating the differentiation of T helper 1 cells and enhancing the cytolytic activity of natural killer (NK) and T cells. Histo…
View article: Supplementary Data from Type I but Not Type II Calreticulin Mutations Activate the IRE1α/XBP1 Pathway of the Unfolded Protein Response to Drive Myeloproliferative Neoplasms
Supplementary Data from Type I but Not Type II Calreticulin Mutations Activate the IRE1α/XBP1 Pathway of the Unfolded Protein Response to Drive Myeloproliferative Neoplasms Open
Supplementary Data from Type I but Not Type II Calreticulin Mutations Activate the IRE1α/XBP1 Pathway of the Unfolded Protein Response to Drive Myeloproliferative Neoplasms
View article: Data from Type I but Not Type II Calreticulin Mutations Activate the IRE1α/XBP1 Pathway of the Unfolded Protein Response to Drive Myeloproliferative Neoplasms
Data from Type I but Not Type II Calreticulin Mutations Activate the IRE1α/XBP1 Pathway of the Unfolded Protein Response to Drive Myeloproliferative Neoplasms Open
Approximately 20% of patients with myeloproliferative neoplasms (MPN) harbor mutations in the gene calreticulin (CALR), with 80% of those mutations classified as either type I or type II. While type II CALR-mutant proteins retain many of t…
View article: Data from Type I but Not Type II Calreticulin Mutations Activate the IRE1α/XBP1 Pathway of the Unfolded Protein Response to Drive Myeloproliferative Neoplasms
Data from Type I but Not Type II Calreticulin Mutations Activate the IRE1α/XBP1 Pathway of the Unfolded Protein Response to Drive Myeloproliferative Neoplasms Open
Approximately 20% of patients with myeloproliferative neoplasms (MPN) harbor mutations in the gene calreticulin (CALR), with 80% of those mutations classified as either type I or type II. While type II CALR-mutant proteins retain many of t…
View article: Supplementary Data from Type I but Not Type II Calreticulin Mutations Activate the IRE1α/XBP1 Pathway of the Unfolded Protein Response to Drive Myeloproliferative Neoplasms
Supplementary Data from Type I but Not Type II Calreticulin Mutations Activate the IRE1α/XBP1 Pathway of the Unfolded Protein Response to Drive Myeloproliferative Neoplasms Open
Supplementary Data from Type I but Not Type II Calreticulin Mutations Activate the IRE1α/XBP1 Pathway of the Unfolded Protein Response to Drive Myeloproliferative Neoplasms
View article: Recurrent activity in neuronal avalanches
Recurrent activity in neuronal avalanches Open
A new statistical analysis of large neuronal avalanches observed in mouse and rat brain tissues reveals a substantial degree of recurrent activity and cyclic patterns of activation not seen in smaller avalanches. To explain these observati…
View article: 841 XTX202, a tumor-selective protein-engineered IL-2, exhibited enhanced anti-tumor activity in combination with checkpoint inhibition in mice
841 XTX202, a tumor-selective protein-engineered IL-2, exhibited enhanced anti-tumor activity in combination with checkpoint inhibition in mice Open
Background High-dose recombinant human interleukin-2 (IL-2, aldesleukin) is approved for the treatment of renal cell carcinoma (RCC) and melanoma based on durable responses. However, use of aldesleukin is limited due to treatment-related l…
View article: Targeting breast and pancreatic cancer metastasis using a dual-cadherin antibody
Targeting breast and pancreatic cancer metastasis using a dual-cadherin antibody Open
The successful application of antibody-based therapeutics in either primary or metastatic cancer depends upon the selection of rare cell surface epitopes that distinguish cancer cells from surrounding normal epithelial cells. By contrast, …
View article: 719 XTX301, a protein-engineered IL-12, exhibits tumor-selective activity in mice without peripheral toxicities and is well tolerated in non-human primates
719 XTX301, a protein-engineered IL-12, exhibits tumor-selective activity in mice without peripheral toxicities and is well tolerated in non-human primates Open
Background Interleukin-12 (IL-12) is a proinflammatory cytokine which bridges innate and adaptive immunity via induction of T helper 1 differentiation and promoting cytolytic activity of natural killer and T cells. IL-12 has demonstrated p…
View article: The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer
The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer Open
Protein arginine methyltransferase 5 (PRMT5) is a type II arginine methyltransferase that catalyzes the post-translational symmetric dimethylation of protein substrates. PRMT5 plays a critical role in regulating biological processes includ…
View article: Evaluation of serological lateral flow assays for severe acute respiratory syndrome coronavirus-2
Evaluation of serological lateral flow assays for severe acute respiratory syndrome coronavirus-2 Open
Background: COVID-19 has resulted in significant morbidity and mortality worldwide. Lateral flow assays can detect anti-Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) antibodies to monitor transmission. However, standardized …
View article: Evaluation of serological lateral flow assays for severe acute respiratory syndrome coronavirus-2
Evaluation of serological lateral flow assays for severe acute respiratory syndrome coronavirus-2 Open
Background COVID-19 has resulted in significant morbidity and mortality worldwide. Lateral flow assays can detect anti-Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) antibodies to monitor transmission. However, standardized e…
View article: Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis
Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis Open
Metastasis: A matter of translation? Solid tumors shed a small number of cancer cells into the bloodstream, some of which are believed to contribute to metastasis. The molecular features that confer these circulating tumor cells (CTCs) wit…
View article: Additional file 3 of A post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells
Additional file 3 of A post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells Open
Table S2. Related to main Figs. 1, 2, 3, 4, 5, 6, 7 and 8. RNAs bearing AU-rich elements (AREs) and up-regulated at the translatome level in G0 cells induced by SS or AraC.
View article: Additional file 2 of A post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells
Additional file 2 of A post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells Open
Table S1. Related to main Figs. 1, 2, 3, 4, 5, 6, 7 and 8. RNAs up-regulated at the translatome level and their RO changes in G0 cells induced by SS or AraC.
View article: Identification of predictive genetic signatures of Cytarabine responsiveness using a 3D acute myeloid leukaemia model
Identification of predictive genetic signatures of Cytarabine responsiveness using a 3D acute myeloid leukaemia model Open
This study reports the establishment of a bone marrow mononuclear cell (BMMC) 3D culture model and the application of this model to define sensitivity and resistance biomarkers of acute myeloid leukaemia (AML) patient bone marrow samples i…
View article: Abstract LB-029: Identification of predictive genetic signatures of Cytarabine responsiveness in acute myeloid leukemia using a novel 3D translational culture model of primary bone marrow
Abstract LB-029: Identification of predictive genetic signatures of Cytarabine responsiveness in acute myeloid leukemia using a novel 3D translational culture model of primary bone marrow Open
Acute myeloid leukemia (AML) is a malignancy with complex genetics, poor survival rates and high rates of chemotherapy resistance. This study reports the establishment of a novel bone marrow mononuclear cell 3D-culture model and the applic…
View article: Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3 + T-regulatory Cell Function and Promotes Antitumor Immunity
Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3 + T-regulatory Cell Function and Promotes Antitumor Immunity Open
Foxp3+ T-regulatory (Treg) cells are known to suppress protective host immune responses to a wide variety of solid tumors, but their therapeutic targeting is largely restricted to their transient depletion or "secondary" modulation, e.g. u…
View article: Differential evolution of peripheral cytokine levels in symptomatic and asymptomatic responses to experimental influenza virus challenge
Differential evolution of peripheral cytokine levels in symptomatic and asymptomatic responses to experimental influenza virus challenge Open
Summary Exposure to influenza virus triggers a complex cascade of events in the human host. In order to understand more clearly the evolution of this intricate response over time, human volunteers were inoculated with influenza A/Wisconsin…