Explanipedia

Epigenomic analysis of KLF1 haploinsufficiency in primary human erythroblasts Open

Steven Heshusius, Laura Grech, Nynke Gillemans, Rutger W. W. Brouwer, Alexander T. den Dekker , et al. · 2022

Bone Marrow Harbors a Unique Population of Dendritic Cells with the Potential to Boost Neutrophil Formation upon Exposure to Fungal Antigen Open

Marieke Goedhart, Edith Slot, María Fernanda Pascutti, Sulima Geerman, Timo Rademakers , et al. · 2021

Apart from controlling hematopoiesis, the bone marrow (BM) also serves as a secondary lymphoid organ, as it can induce naïve T cell priming by resident dendritic cells (DC). When analyzing DCs in murine BM, we uncovered that they are local…

Hemolysis in the spleen drives erythrocyte turnover Open

Thomas R. Klei, Jill Dalimot, Benjamin Nota, Martijn Veldthuis, Erik Mul , et al. · 2020

Red pulp macrophages of the spleen mediate turnover of billions of senescent erythrocytes per day. However, the molecular mechanisms involved in sequestration of senescent erythrocytes, their recognition and their subsequent degradation by…

Alternative trafficking of Weibel‐Palade body proteins in CRISPR/Cas9‐engineered von Willebrand factor–deficient blood outgrowth endothelial cells Open

Maaike Schillemans, Marije Kat, Jurjen Westeneng, Anastasia Gangaev, Menno Hofman , et al. · 2019

Potential of Parameters of Iron Metabolism for the Diagnosis of Anemia of Inflammation in the Critically Ill Open

Margit Boshuizen, Jan M. Binnekade, Benjamin Nota, Kirsten van de Groep, Olaf L. Cremer , et al. · 2019

Background: Anemia of inflammation (AI) is the most common cause of anemia in the critically ill, but its diagnosis is a challenge. New therapies specific to AI are in development, and they require accurate detection of AI. T…

Peripheral and systemic antigens elicit an expandable pool of resident memory CD8 <sup>+</sup> T cells in the bone marrow Open

María Fernanda Pascutti, Sulima Geerman, Nicholas Collins, Giso Brasser, Benjamin Nota , et al. · 2019

BM has been put forward as a major reservoir for memory CD8 + T cells. In order to fulfill that function, BM should “store” memory CD8 + T cells, which in biological terms would require these “stored” memory cells to be in disequilibrium w…

Expression of IL‐7Rα and KLRG1 defines functionally distinct CD8 <sup>+</sup> T‐cell populations in humans Open

Ester B. M. Remmerswaal, Pleun Hombrink, Benjamin Nota, Hanspeter Pircher, Ineke J. M. ten Berge , et al. · 2019

During acute viral infections in mice, IL‐7Rα and KLRG1 together are used to distinguish the short‐lived effector cells (SLEC; IL‐7Rα lo KLRG hi ) from the precursors of persisting memory cells (MPEC; IL‐7Rα hi KLRG1 lo ). We here show tha…

Blimp-1 Rather Than Hobit Drives the Formation of Tissue-Resident Memory CD8+ T Cells in the Lungs Open

Felix M. Behr, Natasja A. M. Kragten, Thomas H. Wesselink, Benjamin Nota, René A. W. van Lier , et al. · 2019

Tissue-resident memory CD8⁺ T (T_RM) cells that develop in the epithelia at portals of pathogen entry are important for improved protection against re-infection. CD8⁺ T_RM cells within the skin and…

Supplementary Material for: Potential of Parameters of Iron Metabolism for the Diagnosis of Anemia of Inflammation in the Critically Ill Open

Margit Boshuizen, Jan M. Binnekade, Benjamin Nota, K. VandeGroep, Olaf L. Cremer , et al. · 2019

Background: Anemia of inflammation (AI) is the most common cause of anemia in the critically ill, but its diagnosis is a challenge. New therapies specific to AI are in development, and they require accurate detection of AI. T…

Integrated proteomic analysis of tumor necrosis factor α and interleukin 1β-induced endothelial inflammation Open

Eelke P. Béguin, Bart L. van den Eshof, Arie J. Hoogendijk, Benjamin Nota, Koen Mertens , et al. · 2018

Secretome Screening Reveals Fibroblast Growth Factors as Novel Inhibitors of Viral Replication Open

Saskia D. van Asten, Matthijs Raaben, Benjamin Nota, Robbert M. Spaapen · 2018

Viruses infect human cells in order to replicate, while human cells aim to resist infection. Several cellular antiviral programs have therefore evolved to resist infection. Knowledge of these programs is essential for the design of antivir…

Iron metabolism in critically ill patients developing anemia of inflammation: a case control study Open

Margit Boshuizen, Jan M. Binnekade, Benjamin Nota, Kirsten van de Groep, Olaf L. Cremer , et al. · 2018

An overview of combined D‐2‐ and L‐2‐hydroxyglutaric aciduria: functional analysis of CIC variants Open

Ana Pop, Monique Williams, Eduard A. Struys, Magnus Monné, Erwin E. W. Jansen , et al. · 2017

Combined D‐2‐ and L‐2‐hydroxyglutaric aciduria (D/L‐2‐HGA) is a devastating neurometabolic disorder, usually lethal in the first years of life. Autosomal recessive mutations in the SLC25A1 gene, which encodes the mitochondrial citrate carr…

TLR4 and C5aR crosstalk in dendritic cells induces a core regulatory network of RSK2, PI3Kβ, SGK1, and FOXO transcription factors Open

Anouk Zaal, Benjamin Nota, Kat Moore, Miranda Dieker, S. Marieke van Ham , et al. · 2017

Crosstalk between complement component 5a receptors (C5aRs) and TLRs in dendritic cells (DCs) occurs upon pathogen invasion; however, studies on C5aR and TLR crosstalk mainly focused on the modulating effect of C5a on TLR-induced cytokine …

Erratum: Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells Open

Pleun Hombrink, Christina Helbig, Ronald A. Backer, Berber Piet, Anna E. Oja , et al. · 2017

First two unrelated cases of isolated sedoheptulokinase deficiency: A benign disorder? Open

Mirjam M. C. Wamelink, Ruben J. J. F. Ramos, Annette P. M. den van Elzen, George J. G. Ruijter, Ramon Bonte , et al. · 2015

We present the first two reported unrelated patients with an isolated sedoheptulokinase (SHPK) deficiency. The first patient presented with neonatal cholestasis, hypoglycemia, and anemia, while the second patient presented with congenital …

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