Benjamin P. Fauber
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View article: Robust High-Dimensional Classification From Few Positive Examples
Robust High-Dimensional Classification From Few Positive Examples Open
We tackle an extreme form of imbalanced classification, with up to 105 features but as few as 5 samples from the minority class. This problem occurs in predicting predicting tumor types and fraud detection, among others. Standard imbalance…
View article: Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase
Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase Open
View article: CCDC 1583516: Experimental Crystal Structure Determination
CCDC 1583516: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice
Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice Open
A series of trisubstituted hydroxylactams was identified as potent enzymatic and cellular inhibitors of human lactate dehydrogenase A. Utilizing structure-based design and physical property optimization, multiple inhibitors were discovered…
View article: Discovery of oxa-sultams as RORc inverse agonists showing reduced lipophilicity, improved selectivity and favorable ADME properties
Discovery of oxa-sultams as RORc inverse agonists showing reduced lipophilicity, improved selectivity and favorable ADME properties Open
View article: Identification of N-sulfonyl-tetrahydroquinolines as RORc inverse agonists
Identification of N-sulfonyl-tetrahydroquinolines as RORc inverse agonists Open
View article: Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists
Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists Open
View article: CCDC 1053998: Experimental Crystal Structure Determination
CCDC 1053998: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …