Benjamin P. Ott
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View article: Determining the Impact of Combination Oral Contraceptives on Von Willebrand Factor and Factor VIII in Healthy Patients and Patients With Von Willebrand Disease: A Scoping Review and Meta‐Analysis
Determining the Impact of Combination Oral Contraceptives on Von Willebrand Factor and Factor VIII in Healthy Patients and Patients With Von Willebrand Disease: A Scoping Review and Meta‐Analysis Open
Introduction Von Willebrand disease (VWD) is a bleeding disorder characterized by a deficiency or dysfunction of Von Willebrand factor (VWF) and/or Factor VIII (FVIII), critical coagulation proteins. Individuals with VWD often use combinat…
View article: Germline and somatic variants in <i>DNMT3A</i> and other clonal haematopoiesis of indeterminate potential genes contribute to pulmonary arterial hypertension
Germline and somatic variants in <i>DNMT3A</i> and other clonal haematopoiesis of indeterminate potential genes contribute to pulmonary arterial hypertension Open
Background and Aims Multiple germline gene variants promote familial and idiopathic pulmonary arterial hypertension (PAH); however, none are consistently identified in associated PAH with connective tissue disease (APAH-CTD). Moreover, the…
View article: NDUFS2 (NADH:Ubiquinone oxidoreductase core subunit S2) in Mitochondrial Electron Transport Chain Complex I is Critical to Oxygen Responsiveness of Human Ductus Arteriosus Smooth Muscle Cells
NDUFS2 (NADH:Ubiquinone oxidoreductase core subunit S2) in Mitochondrial Electron Transport Chain Complex I is Critical to Oxygen Responsiveness of Human Ductus Arteriosus Smooth Muscle Cells Open
Rationale: Mitochondria in ductus arteriosus (DA) smooth muscle cells (DASMC) are oxygen sensors that trigger O2-induced vasoconstriction at birth; however, the molecular mechanisms of mitochondrial oxygen sensing are not fully understood.…
View article: Tet Methylcytosine Dioxygenase 2 (<scp><i>TET2</i></scp>) Mutation Drives a Global Hypermethylation Signature in Patients With Pulmonary Arterial Hypertension (<scp>PAH</scp>): Correlation With Altered Gene Expression Relevant to a Common T Cell Phenotype
Tet Methylcytosine Dioxygenase 2 (<span><i>TET2</i></span>) Mutation Drives a Global Hypermethylation Signature in Patients With Pulmonary Arterial Hypertension (<span>PAH</span>): Correlation With Altered Gene Expression Relevant to a Common T Cell Phenotype Open
Epigenetic changes in gene expression due to DNA methylation regulate pulmonary vascular structure and function. Genetic or acquired alterations in DNA methylation/demethylation can promote the development of pulmonary arterial hypertensio…
View article: Role of Dynamin 2 in mitochondrial fission and cell cycle regulation:<i>Dysregulation of a miR-124-3p-STAT3-DNM2-Drp1-RGCC pathway connects fission and cell proliferation in pulmonary arterial hypertension</i>
Role of Dynamin 2 in mitochondrial fission and cell cycle regulation:<i>Dysregulation of a miR-124-3p-STAT3-DNM2-Drp1-RGCC pathway connects fission and cell proliferation in pulmonary arterial hypertension</i> Open
Introduction Dynamin-related protein 1 (Drp1) activation increases mitochondrial fission and cell cycle progression in hyperproliferative cells, termed mitotic fission . However, the diameter of a fission apparatus comprised solely of Drp1…
View article: Robust Multitaper Tests for Detecting Frequency Modulated Signals
Robust Multitaper Tests for Detecting Frequency Modulated Signals Open
In this paper, we propose a new test for the detection of polynomial modulated signals, as well as an aggregated test based on the new test. The test statistics are developed under the multitaper spectral framework, and are designed to be …