Benjamin Prudon
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View article: Long-term follow-up of treatment comparisons in RECOVERY: a randomised, open-label, platform trial for patients hospitalised with COVID-19
Long-term follow-up of treatment comparisons in RECOVERY: a randomised, open-label, platform trial for patients hospitalised with COVID-19 Open
SUMMARY Background The Randomised Evaluation of COVID-19 Therapy (RECOVERY) trial evaluated the effects of sixteen potential treatments for patients hospitalised with COVID-19. Dexamethasone (at a dose of 6mg daily), tocilizumab, baricitin…
View article: The impact of outpatient<i>versus</i>inpatient management on health-related quality of life outcomes for patients with malignant pleural effusion: the OPTIMUM randomised clinical trial
The impact of outpatient<i>versus</i>inpatient management on health-related quality of life outcomes for patients with malignant pleural effusion: the OPTIMUM randomised clinical trial Open
Background The principal aim of malignant pleural effusion (MPE) management is to improve health-related quality of life (HRQoL) and symptoms. Methods In this open-label randomised controlled trial, patients with symptomatic MPE were rando…
View article: Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial Open
SUMMARY Background Dimethyl fumarate (DMF) is an anti-inflammatory drug that has been proposed as a treatment for patients hospitalised with COVID-19 Methods This randomised, controlled, open-label platform trial (Randomised Evaluation of …
View article: Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis
Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis Open
SUMMARY Background We evaluated the use of baricitinib, a Janus kinase (JAK) 1/2 inhibitor, for the treatment of patients admitted to hospital because of COVID-19. Methods This randomised, controlled, open-label platform trial (Randomised …
View article: Randomised trial of indwelling pleural catheters for refractory transudative pleural effusions
Randomised trial of indwelling pleural catheters for refractory transudative pleural effusions Open
Objective Refractory symptomatic transudative pleural effusions are an indication for pleural drainage. There has been supportive observational evidence for the use of indwelling pleural catheters (IPCs) for transudative effusions, but no …
View article: Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial Open
SUMMARY Background REGEN-COV is a combination of 2 monoclonal antibodies (casirivimab and imdevimab) that bind to two different sites on the receptor binding domain of the SARS-CoV-2 spike protein. We aimed to evaluate the efficacy and saf…
View article: Colchicine in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Colchicine in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial Open
SUMMARY Background Colchicine has been proposed as a treatment for COVID-19 on the basis of its anti-inflammatory actions. Methods In this randomised, controlled, open-label trial, several possible treatments were compared with usual care …
View article: Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19
Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19 Open
BACKGROUND: Hydroxychloroquine and chloroquine have been proposed as treatments for coronavirus disease 2019 (Covid-19) on the basis of in vitro activity and data from uncontrolled studies and small, randomized trials. METHODS: In this ran…
View article: Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial Open
View article: Dexamethasone in Hospitalized Patients with Covid-19.
Dexamethasone in Hospitalized Patients with Covid-19. Open
BACKGROUND: Coronavirus disease 2019 (Covid-19) is associated with diffuse lung damage. Glucocorticoids may modulate inflammation-mediated lung injury and thereby reduce progression to respiratory failure and death. METHODS: In this contro…
View article: Effect of Hydroxychloroquine in Hospitalized Patients with COVID-19: Preliminary results from a multi-centre, randomized, controlled trial
Effect of Hydroxychloroquine in Hospitalized Patients with COVID-19: Preliminary results from a multi-centre, randomized, controlled trial Open
Background Hydroxychloroquine and chloroquine have been proposed as treatments for coronavirus disease 2019 (COVID-19) on the basis of in vitro activity, uncontrolled data, and small randomized studies. Methods The Randomised Evaluation of…
View article: Effect of Dexamethasone in Hospitalized Patients with COVID-19 – Preliminary Report
Effect of Dexamethasone in Hospitalized Patients with COVID-19 – Preliminary Report Open
Background Coronavirus disease 2019 (COVID-19) is associated with diffuse lung damage. Corticosteroids may modulate immune-mediated lung injury and reducing progression to respiratory failure and death. Methods The Randomised Evaluation of…
View article: Effect of Thoracoscopic Talc Poudrage vs Talc Slurry via Chest Tube on Pleurodesis Failure Rate Among Patients With Malignant Pleural Effusions
Effect of Thoracoscopic Talc Poudrage vs Talc Slurry via Chest Tube on Pleurodesis Failure Rate Among Patients With Malignant Pleural Effusions Open
ISRCTN Identifier: ISRCTN47845793.
View article: Continuous positive airway pressure effect on visual acuity in patients with type 2 diabetes and obstructive sleep apnoea: a multicentre randomised controlled trial
Continuous positive airway pressure effect on visual acuity in patients with type 2 diabetes and obstructive sleep apnoea: a multicentre randomised controlled trial Open
We sought to establish whether continuous positive airway pressure (CPAP) for obstructive sleep apnoea (OSA) in people with type 2 diabetes and diabetic macular oedema (DMO) improved visual acuity. We randomly assigned 131 eligible patient…
View article: A Randomised Controlled Trial Of The Effect Of CPAP On Diabetic Macular Oedema In People With Concurrent Obstructive Sleep Apnoea
A Randomised Controlled Trial Of The Effect Of CPAP On Diabetic Macular Oedema In People With Concurrent Obstructive Sleep Apnoea Open
View article: P72 Baseline data from the rosa trial: a randomised controlled trial of the effect of CPAP on diabetic macular oedema in people with concurrent obstructive sleep apnoea
P72 Baseline data from the rosa trial: a randomised controlled trial of the effect of CPAP on diabetic macular oedema in people with concurrent obstructive sleep apnoea Open
The ROSA trial (Retinopathy and Obstructive Sleep Apnoea) is a multi-centre randomised controlled trial conducted in the United Kingdom. The hypothesis is that CPAP (continuous positive airway pressure) will improve visual acuity in people…
View article: S26 Is the “time spent with saturations below 90%” on sleep study helpful in identifying Obesity Hypoventilation Syndrome in the Sleep Clinic?
S26 Is the “time spent with saturations below 90%” on sleep study helpful in identifying Obesity Hypoventilation Syndrome in the Sleep Clinic? Open
Introduction Obesity Hypoventilation Syndrome (OHS) is defined as sleep disordered breathing, obesity, and daytime hypercapnia, without another cause of ventilatory impairment.1 Recent studies have shown that a raised base exces…