Benjamin Schattling
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View article: Genetic Risk Profiling Reveals Altered Glycosyltransferase Expression as a Predictor for Patient Outcome in Neuroblastoma
Genetic Risk Profiling Reveals Altered Glycosyltransferase Expression as a Predictor for Patient Outcome in Neuroblastoma Open
Background/Objectives: Neuroblastoma is a highly aggressive pediatric cancer that arises from immature nerve cells and exhibits a broad spectrum of clinical presentations. While low- and intermediate-risk neuroblastomas often have favorabl…
View article: MicroRNA-92a–CPEB3 axis protects neurons against inflammatory neurodegeneration
MicroRNA-92a–CPEB3 axis protects neurons against inflammatory neurodegeneration Open
Neuroinflammation causes neuronal injury in multiple sclerosis (MS) and other neurological diseases. MicroRNAs (miRNAs) are important modulators of neuronal stress responses, but knowledge about their contribution to neuronal protection or…
View article: Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis
Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis Open
While transcripts of neuronal mitochondrial genes are strongly suppressed in central nervous system inflammation, it is unknown whether this results in mitochondrial dysfunction and whether an increase of mitochondrial function can rescue …
View article: Author response: Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis
Author response: Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract While transcripts of neuronal…
View article: TRPV4-Mediated Regulation of the Blood Brain Barrier Is Abolished During Inflammation
TRPV4-Mediated Regulation of the Blood Brain Barrier Is Abolished During Inflammation Open
Blood-brain barrier (BBB) dysfunction is critically involved in determining the extent of several central nervous systems (CNS) pathologies and here in particular neuroinflammatory conditions. Inhibiting BBB breakdown could reduce the leve…
View article: Enhancing mitochondrial activity in neurons protects against neurodegeneration in CNS inflammation
Enhancing mitochondrial activity in neurons protects against neurodegeneration in CNS inflammation Open
Central nervous system (CNS) inflammation in multiple sclerosis (MS) drives neuro-axonal loss resulting in irreversible disability. While transcripts of mitochondrial genes are strongly suppressed in neurons during CNS inflammation, it is …
View article: Activity of NaV1.2 promotes neurodegeneration in an animal model of multiple sclerosis
Activity of NaV1.2 promotes neurodegeneration in an animal model of multiple sclerosis Open
Counteracting the progressive neurological disability caused by neuronal and axonal loss is the major unmet clinical need in multiple sclerosis therapy. However, the mechanisms underlying irreversible neuroaxonal degeneration in multiple s…