Benjamin Schuler
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View article: Mapping Charge Interactions in Intrinsically Disordered Proteins
Mapping Charge Interactions in Intrinsically Disordered Proteins Open
Intrinsically disordered proteins (IDPs) are often rich in charged residues, and electrostatic interactions have a pronounced effect on their conformational distributions, interactions and functions. However, attaining quantitative underst…
View article: Dynamical buffering of reconfiguration dynamics in intrinsically disordered proteins
Dynamical buffering of reconfiguration dynamics in intrinsically disordered proteins Open
The dynamics of intrinsically disordered proteins are important for their function, allowing their heterogeneous conformational ensembles to rapidly reconfigure in response to binding partners or changes in solution conditions. However, th…
View article: Material properties of biomolecular condensates emerge from nanoscale dynamics.
Material properties of biomolecular condensates emerge from nanoscale dynamics. Open
Biomolecular condensates form by phase separation of biological polymers and have important functions in the cell - functions that are inherently linked to their physical properties at different scales. A notable aspect of such membraneles…
View article: Material properties of biomolecular condensates emerge from nanoscale dynamics
Material properties of biomolecular condensates emerge from nanoscale dynamics Open
Biomolecular condensates form by phase separation of biological polymers and have important functions in the cell—functions that are inherently linked to their physical properties at different scales. A notable aspect of such membraneless …
View article: Associations of Tackling Characteristics, Player Position, and Head Contact Risk During Game Play in College Football
Associations of Tackling Characteristics, Player Position, and Head Contact Risk During Game Play in College Football Open
Context Sport-related concussion is a common injury among National Collegiate Athletic Association football athletes. Beginning with the 2016 season, Ivy League Conference coaches voted to ban player-on-player tackling from all in-season p…
View article: Hybrid Photonic Integrated Circuits for Wireless Transceivers
Hybrid Photonic Integrated Circuits for Wireless Transceivers Open
Recent advancements in hybrid photonic integrated circuits (PICs) for wireless communications are reviewed, with a focus on innovations developed at Fraunhofer HHI. This work leverages hybrid integration technology, which combines indium p…
View article: Role of charges in a dynamic disordered complex between an IDP and a folded domain
Role of charges in a dynamic disordered complex between an IDP and a folded domain Open
Protein complexes involving intrinsically disordered proteins (IDPs) cover a continuum from IDPs that fully fold upon binding to IDPs that remain fully disordered in the complex. Here we demonstrate a case of charge-driven interactions of …
View article: Towards a Unified Framework for Determining Conformational Ensembles of Disordered Proteins
Towards a Unified Framework for Determining Conformational Ensembles of Disordered Proteins Open
Disordered proteins play essential roles in myriad cellular processes, yet their structural characterization remains a major challenge due to their dynamic and heterogeneous nature. We here present a community-driven initiative to address …
View article: Hybrid Photonic Integrated Circuits for Wireless Transceivers
Hybrid Photonic Integrated Circuits for Wireless Transceivers Open
Recently developed photonic integrated circuits (PICs) for wireless communications are reviewed. These PICs leverage hybrid integration technology, which combines InP active elements, silicon nitride (Si3N4) low-loss waveguides, high-effic…
View article: Stereochemistry in the disorder–order continuum of protein interactions
Stereochemistry in the disorder–order continuum of protein interactions Open
Intrinsically disordered proteins can bind via the formation of highly disordered protein complexes without the formation of three-dimensional structure1. Most naturally occurring proteins are levorotatory (L)-that is, made up only of L-am…
View article: Identifying Sequence Effects on Chain Dimensions of Disordered Proteins by Integrating Experiments and Simulations
Identifying Sequence Effects on Chain Dimensions of Disordered Proteins by Integrating Experiments and Simulations Open
It has become increasingly evident that the conformational distributions of intrinsically disordered proteins or regions are strongly dependent on their amino acid compositions and sequence. To facilitate a systematic investigation of thes…
View article: The molecular basis of lamin-specific chromatin interactions
The molecular basis of lamin-specific chromatin interactions Open
In the cell nucleus, chromatin is anchored to the nuclear lamina, a network of lamin filaments and binding proteins that underly the inner nuclear membrane. The nuclear lamina is involved in chromatin organisation through the interaction o…
View article: The importance of stereochemistry in the disorder-order continuum of protein-protein interactions
The importance of stereochemistry in the disorder-order continuum of protein-protein interactions Open
Intrinsically disordered proteins can bind via the formation of highly disordered protein complexes without the formation of 3D-structure. Most naturally occurring proteins are “left-handed” or levorotatory (L), made up only of L-amino aci…
View article: Association of Use of a Mobile Tackling Dummy During College Football Practice With Reduced Sport-Related Concussion: Results of a Pilot Investigation
Association of Use of a Mobile Tackling Dummy During College Football Practice With Reduced Sport-Related Concussion: Results of a Pilot Investigation Open
Background: Considering the multifaceted consequences of improperly managed sport-related concussions (SRCs) in American football, identifying efficacious prevention measures for enhancing player safety is crucial. Purpose: To investigate …
View article: Nanosecond chain dynamics of single-stranded nucleic acids
Nanosecond chain dynamics of single-stranded nucleic acids Open
The conformational dynamics of single-stranded nucleic acids are fundamental for nucleic acid folding and function. However, their elementary chain dynamics have been difficult to resolve experimentally. Here we employ a combination of sin…
View article: Single-Molecule FRET at 10 MHz Count Rates
Single-Molecule FRET at 10 MHz Count Rates Open
A bottleneck in many studies utilizing single-molecule Förster Resonance Energy Transfer (smFRET) is the attainable photon count rate as it determines the temporal resolution of the experiment. As many biologically relevant processes occur…
View article: Driving forces of the complex formation between highly charged disordered proteins
Driving forces of the complex formation between highly charged disordered proteins Open
Highly disordered complexes between oppositely charged intrinsically disordered proteins present a new paradigm of biomolecular interactions. Here, we investigate the driving forces of such interactions for the example of the highly positi…
View article: A Quantitative Description for Optical Mass Measurement of Single Biomolecules
A Quantitative Description for Optical Mass Measurement of Single Biomolecules Open
Label-free detection of single biomolecules in solution has been achieved using a variety of experimental approaches over the past decade. Yet, our understanding of the magnitude of the optical contrast and its relationship with the underl…
View article: Extreme dynamics in a biomolecular condensate
Extreme dynamics in a biomolecular condensate Open
Simulation inputs, subsampled trajectory, and outputs of lifetime calculation from paper "Extreme dynamics in a biomolecular condensate". Lifetime outputs are provided because these cannot be correctly calculated from the subsampled trajec…
View article: Extreme dynamics in a biomolecular condensate
Extreme dynamics in a biomolecular condensate Open
Simulation inputs, subsampled trajectory, and outputs of lifetime calculation from paper "Extreme dynamics in a biomolecular condensate". Lifetime outputs are provided because these cannot be correctly calculated from the subsampled trajec…
View article: A quantitative description for optical mass measurement of single biomolecules
A quantitative description for optical mass measurement of single biomolecules Open
Label-free detection of single biomolecules in solution has been achieved using a variety of experimental approaches over the past decade. Yet, our understanding of the magnitude of the optical contrast and its relationship to the underlyi…
View article: Interaction Dynamics of Intrinsically Disordered Proteins from Single-Molecule Spectroscopy
Interaction Dynamics of Intrinsically Disordered Proteins from Single-Molecule Spectroscopy Open
Many proteins contain large structurally disordered regions or are entirely disordered under physiological conditions. The functions of these intrinsically disordered proteins (IDPs) often involve interactions with other biomolecules. An i…