Benjamin Galeota-Sprung
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View article: Directed evolution for cell separation in natural isolates of budding yeast reveals negative selection on <i>AMN1</i> and the Rim101 pathway in haploids and positive selection for Hawthorne’s deletion in diploids
Directed evolution for cell separation in natural isolates of budding yeast reveals negative selection on <i>AMN1</i> and the Rim101 pathway in haploids and positive selection for Hawthorne’s deletion in diploids Open
Natural isolates of the yeast Saccharomyces cerevisiae were evolved under a transfer protocol that selected for cell separation and against clumpy growth. Whole-genome sequencing of haploid populations revealed strong selection to deactiva…
View article: Changes to the mtDNA copy number during yeast culture growth
Changes to the mtDNA copy number during yeast culture growth Open
We show that the mitochondrial DNA (mtDNA) copy number in growing cultures of the yeast Saccharomyces cerevisiae increases by a factor of up to 4, being lowest (approx. 10 per haploid genome) and stable during rapid fermentative growth, an…
View article: Changes to the mtDNA copy number during yeast culture growth
Changes to the mtDNA copy number during yeast culture growth Open
We show that the mtDNA copy number in growing cultures of the yeast Saccharomyces cerevisiae increases by a factor of up to 4, being lowest (∼10 per haploid genome) and stable during rapid fermentative growth, and highest at the end of the…
View article: How unequal vaccine distribution promotes the evolution of vaccine escape
How unequal vaccine distribution promotes the evolution of vaccine escape Open
Health officials warn that SARS-CoV-2 vaccines must be uniformly distributed within and among countries if we are to quell the ongoing pandemic. Yet there has been little critical assessment of the underlying reasons for this warning. Here…
View article: How unequal vaccine distribution promotes the evolution of vaccine escape
How unequal vaccine distribution promotes the evolution of vaccine escape Open
Health officials warn that SARS-CoV-2 vaccines must be uniformly distributed within and among countries if we are to quell the ongoing pandemic. Yet there has been little critical assessment of the underlying reasons for this warning. Here…
View article: Natural selection and the advantage of recombination
Natural selection and the advantage of recombination Open
Exchanging genetic material with another individual seems risky from an evolutionary standpoint, and yet living things across all scales and phyla do so quite regularly. The pervasiveness of such genetic exchange, or recombination, in natu…
View article: Natural selection and the advantage of recombination
Natural selection and the advantage of recombination Open
The ubiquity of sex and recombination in nature is widely viewed as enigmatic, despite an abundance of limited-scope explanations. Natural selection, it seems, should amplify well-matched combinations of genes. Recombination would break up…
View article: Mutational Load and the Functional Fraction of the Human Genome
Mutational Load and the Functional Fraction of the Human Genome Open
The fraction of the human genome that is functional is a question of both evolutionary and practical importance. Studies of sequence divergence have suggested that the functional fraction of the human genome is likely to be no more than ∼1…
View article: The Evolution of Genetic Systems: The Influence of Recombination, Mutation Rate, and Mutational Load
The Evolution of Genetic Systems: The Influence of Recombination, Mutation Rate, and Mutational Load Open
This dissertation investigates the influence of recombination upon the evolution of mutation rates, and the properties of mutational load in evolving populations, using the tools of experimental evolution. It is shown, in Chapter 1, that c…
View article: Mutational load and the functional fraction of the human genome
Mutational load and the functional fraction of the human genome Open
The fraction of the human genome that is functional is a question of both evolutionary and practical importance. Studies of sequence divergence have suggested that the functional fraction of the human genome is likely to be no more than ∼1…
View article: The fitness cost of mismatch repair mutators in<i>Saccharomyces cerevisiae</i>: partitioning the mutational load
The fitness cost of mismatch repair mutators in<i>Saccharomyces cerevisiae</i>: partitioning the mutational load Open
Mutational load is the depression in a population’s mean fitness that results from the continual influx of deleterious mutations. Here, we directly estimate the mutational load in a population of haploid Saccharomyces cerevisiae that are d…