Benjamin T. Walters
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View article: Rational design of potent small-molecule SMARCA2/A4 degraders acting via the recruitment of FBXO22
Rational design of potent small-molecule SMARCA2/A4 degraders acting via the recruitment of FBXO22 Open
View article: Rational design of potent small molecule SMARCA2/A4(BRM/BRG1) degraders acting via the recruitment of FBXO22
Rational design of potent small molecule SMARCA2/A4(BRM/BRG1) degraders acting via the recruitment of FBXO22 Open
Target-anchored monovalent degraders are more drug-like than their bivalent counterparts, Proteolysis Targeting Chimeras (PROTACs), while offering greater target specificity control than the E3 ligase-anchored monovalent degraders, also kn…
View article: Rational design of potent small molecule SMARCA2/A4 (BRM/BRG1) degraders acting via the recruitment of FBXO22
Rational design of potent small molecule SMARCA2/A4 (BRM/BRG1) degraders acting via the recruitment of FBXO22 Open
Target-anchored monovalent degraders are more drug-like than their bivalent counterparts, Proteolysis Targeting Chimeras (PROTACs), while offering greater target specificity control than the E3 ligase-anchored monovalent degraders, also kn…
View article: Integrating Hydrogen Exchange with Molecular Dynamics for Improved Ligand Binding Predictions
Integrating Hydrogen Exchange with Molecular Dynamics for Improved Ligand Binding Predictions Open
We introduce Hydrogen-Exchange Experimental Structure Prediction (HX-ESP), a method that integrates hydrogen exchange (HX) data with molecular dynamics (MD) simulations to accurately predict ligand binding modes, even for targets requiring…
View article: TANGO2: A Rare but Important Mutation
TANGO2: A Rare but Important Mutation Open
We report the case of a 7-year-old boy who presented with post-viral myositis, rhabdomyolysis, and hepatitis, who was later readmitted due to a seizure-like activity and ultimately found to have episodes of recalcitrant polymorphic ventric…
View article: HPK1 citron homology domain regulates phosphorylation of SLP76 and modulates kinase domain interaction dynamics
HPK1 citron homology domain regulates phosphorylation of SLP76 and modulates kinase domain interaction dynamics Open
View article: Engagement in the Data Collection Phase of the Scientific Process is Key for Enhancing Learning Gains
Engagement in the Data Collection Phase of the Scientific Process is Key for Enhancing Learning Gains Open
Most programs that create opportunities for the public to engage in scientific research invite the public to collect data, but there is a call to expand opportunities for engagement in additional aspects of the scientific process. One reas…
View article: Bivalent antibody pliers inhibit β-tryptase by an allosteric mechanism dependent on the IgG hinge
Bivalent antibody pliers inhibit β-tryptase by an allosteric mechanism dependent on the IgG hinge Open
View article: Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands
Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands Open
View article: Multiscale Coarse-Grained Approach to Investigate Self-Association of Antibodies
Multiscale Coarse-Grained Approach to Investigate Self-Association of Antibodies Open
View article: An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma
An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma Open
View article: Dissecting the molecular basis of high viscosity of monospecific and bispecific IgG antibodies
Dissecting the molecular basis of high viscosity of monospecific and bispecific IgG antibodies Open
Some antibodies exhibit elevated viscosity at high concentrations, making them poorly suited for therapeutic applications requiring administration by injection such as subcutaneous or ocular delivery. Here we studied an anti-IL-13/IL-17 bi…
View article: An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma
An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma Open
View article: Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation
Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation Open
View article: Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments
Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments Open
View article: Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS) Centroid Data Measured between 3.6 °C and 25.4 °C for the Fab Fragment of NISTmAb
Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS) Centroid Data Measured between 3.6 °C and 25.4 °C for the Fab Fragment of NISTmAb Open
The spreadsheet file reported herein provides centroid data, descriptive of deuterium uptake, for the FabFragment of NISTmAb (PDB: 5K8A) reference material, as measured by the bottom-up hydrogen-deuterium exchange mass spectrometry (HDX-MS…
View article: An Allosteric Anti-Tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma
An Allosteric Anti-Tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma Open
View article: Helical assembly of the CARD9 CARD
Helical assembly of the CARD9 CARD Open
CARD9 and CARD11 drive immune cell activation by nucleating Bcl10 polymerization, but are held in an autoinhibited state prior to stimulation. Here, we elucidate the structural basis for this autoinhibition by determining the structure of …
View article: Mutational landscape of antibody variable domains reveals a switch modulating the interdomain conformational dynamics and antigen binding
Mutational landscape of antibody variable domains reveals a switch modulating the interdomain conformational dynamics and antigen binding Open
Significance On encountering antigens, antibody’s variable domains evolve and mature through multiple rounds of somatic mutation. By surveying the effects of all possible single mutations of an antibody’s variable domains on folding stabil…
View article: Conformational Destabilization of Immunoglobulin G Increases the Low pH Binding Affinity with the Neonatal Fc Receptor
Conformational Destabilization of Immunoglobulin G Increases the Low pH Binding Affinity with the Neonatal Fc Receptor Open