Benjamin VanderSluis
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View article: Environmental robustness of the global yeast genetic interaction network
Environmental robustness of the global yeast genetic interaction network Open
Environmental impacts on gene networks A phenotype can be affected by genes interacting with other genes, the environment, or both other genes and the environment (a differential interaction). To better understand how these interactions fu…
View article: Systematic exploration of essential yeast gene function with temperature-sensitive mutants
Systematic exploration of essential yeast gene function with temperature-sensitive mutants Open
Conditional temperature-sensitive (ts) mutations are valuable reagents for studying essential genes in the yeast Saccharomyces cerevisiae. We constructed 787 ts strains, covering 497 (~45%) of the 1,101 essential yeast genes, with ~30% of …
View article: Exploring whole-genome duplicate gene retention with complex genetic interaction analysis
Exploring whole-genome duplicate gene retention with complex genetic interaction analysis Open
The fate of genes after duplication Gene duplication within an organism is a relatively common event during evolution. However, we cannot predict the fate of the duplicated genes: Will they be lost, evolve, or overlap in function within an…
View article: Discovering genetic interactions bridging pathways in genome-wide association studies
Discovering genetic interactions bridging pathways in genome-wide association studies Open
Genetic interactions have been reported to underlie phenotypes in a variety of systems, but the extent to which they contribute to complex disease in humans remains unclear. In principle, genome-wide association studies (GWAS) provide a pl…
View article: Data from: Systematic analysis of complex genetic interactions
Data from: Systematic analysis of complex genetic interactions Open
To systematically explore complex genetic interactions, we constructed ~200,000 yeast triple mutants and scored negative trigenic interactions. We selected double-mutant query genes across a broad spectrum of biological processes, spanning…
View article: TheCellMap.org: A Web-Accessible Database for Visualizing and Mining the Global Yeast Genetic Interaction Network
TheCellMap.org: A Web-Accessible Database for Visualizing and Mining the Global Yeast Genetic Interaction Network Open
Providing access to quantitative genomic data is key to ensure large-scale data validation and promote new discoveries. TheCellMap.org serves as a central repository for storing and analyzing quantitative genetic interaction data produced …
View article: Exploring genetic suppression interactions on a global scale
Exploring genetic suppression interactions on a global scale Open
A global genetic suppression network The genetic background of an organism can influence the overall effects of new genetic variants. Some mutations can amplify a deleterious phenotype, whereas others can suppress it. Starting with a liter…
View article: A global genetic interaction network maps a wiring diagram of cellular function
A global genetic interaction network maps a wiring diagram of cellular function Open
INTRODUCTION Genetic interactions occur when mutations in two or more genes combine to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic interaction occurs when two mutations, neither lethal individually, co…