Benjamin Vollmer
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View article: A nanobody specific to prefusion glycoprotein B neutralizes HSV-1 and HSV-2
A nanobody specific to prefusion glycoprotein B neutralizes HSV-1 and HSV-2 Open
The nine human herpesviruses, including herpes simplex virus 1 and 2, human cytomegalovirus and Epstein–Barr virus, present a significant burden to global public health 1 . Their envelopes contain at least ten different glycoproteins, whic…
View article: A critical residue in a conserved RBD epitope determines neutralization breadth of pan-sarbecovirus antibodies with recurring YYDRxxG motifs
A critical residue in a conserved RBD epitope determines neutralization breadth of pan-sarbecovirus antibodies with recurring YYDRxxG motifs Open
The emergence of pandemic coronaviruses remains a global health concern, highlighting the need for broadly neutralizing antibodies (bnAbs) that can target multiple sarbecoviruses. In this study, we isolated and characterized a novel antibo…
View article: Targeted mutagenesis of the herpesvirus fusogen central helix captures transition states
Targeted mutagenesis of the herpesvirus fusogen central helix captures transition states Open
Herpesviruses remain a burden for animal and human health, including the medically important varicella-zoster virus (VZV). Membrane fusion mediated by conserved core glycoproteins, the fusogen gB and the heterodimer gH-gL, enables herpesvi…
View article: Stabilisation of Viral Membrane Fusion Proteins in Prefusion Conformation by Structure-Based Design for Structure Determination and Vaccine Development
Stabilisation of Viral Membrane Fusion Proteins in Prefusion Conformation by Structure-Based Design for Structure Determination and Vaccine Development Open
The membrane surface of enveloped viruses contains dedicated proteins enabling the fusion of the viral with the host cell membrane. Working with these proteins is almost always challenging because they are membrane-embedded and naturally m…
View article: Biophysical Screening Pipeline for Cryo-EM Grid Preparation of Membrane Proteins
Biophysical Screening Pipeline for Cryo-EM Grid Preparation of Membrane Proteins Open
Successful sample preparation is the foundation to any structural biology technique. Membrane proteins are of particular interest as these are important targets for drug design, but also notoriously difficult to work with. For electron cry…
View article: Assembly of infectious Kaposi’s sarcoma-associated herpesvirus progeny requires formation of a pORF19 pentamer
Assembly of infectious Kaposi’s sarcoma-associated herpesvirus progeny requires formation of a pORF19 pentamer Open
Herpesviruses cause severe diseases particularly in immunocompromised patients. Both genome packaging and release from the capsid require a unique portal channel occupying one of the 12 capsid vertices. Here, we report the 2.6 Å crystal st…
View article: <i>In Vitro</i> Viral Evolution Identifies a Critical Residue in the Alphaherpesvirus Fusion Glycoprotein B Ectodomain That Controls gH/gL-Independent Entry
<i>In Vitro</i> Viral Evolution Identifies a Critical Residue in the Alphaherpesvirus Fusion Glycoprotein B Ectodomain That Controls gH/gL-Independent Entry Open
The class III fusion protein glycoprotein B (gB) drives membrane fusion during entry and spread of herpesviruses. To mediate fusion, gB requires activation by the conserved gH/gL complex by a poorly defined mechanism.
View article: DNA origami signposts for identifying proteins on cell membranes by electron cryotomography
DNA origami signposts for identifying proteins on cell membranes by electron cryotomography Open
View article: The prefusion structure of herpes simplex virus glycoprotein B
The prefusion structure of herpes simplex virus glycoprotein B Open
Elusive, pharmacologically relevant conformation of the herpesvirus fusion protein is revealed by a multi-methodological approach.
View article: Protein interactions and consensus clustering analysis uncover insights into herpesvirus virion structure and function relationships
Protein interactions and consensus clustering analysis uncover insights into herpesvirus virion structure and function relationships Open
Infections with human herpesviruses are ubiquitous and a public health concern worldwide. Current treatments reduce the severity of some symptoms associated to herpetic infections but neither remove the viral reservoir from the infected ho…
View article: Consensus clustering of herpesvirus protein interaction networks provides insights into their evolutionary relationship with bacteriophages
Consensus clustering of herpesvirus protein interaction networks provides insights into their evolutionary relationship with bacteriophages Open
Infections with human herpesviruses are ubiquitous and a public health concern worldwide. Current treatments reduce the morbidity of some manifested symptoms but neither remove the viral reservoir from the infected host nor protect from th…
View article: Two distinct trimeric conformations of natively membrane-anchored full-length herpes simplex virus 1 glycoprotein B
Two distinct trimeric conformations of natively membrane-anchored full-length herpes simplex virus 1 glycoprotein B Open
Significance Successful host cell infection requires that viruses get various components—most importantly, their genomes—across the bounding membranes into the cytosol. For enveloped viruses, this crucial part of the entry process is achie…
View article: In situ structural analysis of the human nuclear pore complex
In situ structural analysis of the human nuclear pore complex Open
View article: Nup153 Recruits the Nup107-160 Complex to the Inner Nuclear Membrane for Interphasic Nuclear Pore Complex Assembly
Nup153 Recruits the Nup107-160 Complex to the Inner Nuclear Membrane for Interphasic Nuclear Pore Complex Assembly Open
View article: A Single Herpesvirus Protein Can Mediate Vesicle Formation in the Nuclear Envelope
A Single Herpesvirus Protein Can Mediate Vesicle Formation in the Nuclear Envelope Open
View article: The membrane interaction of Nup53 and its implication in nuclear pore complex assembly
The membrane interaction of Nup53 and its implication in nuclear pore complex assembly Open
Nuclear pores are established at fusion points of the outer and the inner nuclear membrane and are stabilized by the proteins of the nuclear pore complex (NPC). These huge protein assemblies form the selective gate, which allows a bidirect…