Benjamine Liu
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View article: Identification of a possible proteomic biomarker in Parkinson’s disease: discovery and replication in blood, brain and cerebrospinal fluid
Identification of a possible proteomic biomarker in Parkinson’s disease: discovery and replication in blood, brain and cerebrospinal fluid Open
Biomarkers to aid diagnosis and delineate the progression of Parkinson’s disease are vital for targeting treatment in the early phases of the disease. Here, we aim to discover a multi-protein panel representative of Parkinson’s and make me…
View article: Predicting progression to Alzheimer’s disease with human hippocampal progenitors exposed to serum
Predicting progression to Alzheimer’s disease with human hippocampal progenitors exposed to serum Open
Adult hippocampal neurogenesis is important for learning and memory and is altered early in Alzheimer’s disease. As hippocampal neurogenesis is modulated by the circulatory systemic environment, evaluating a proxy of how hippocampal neurog…
View article: Identification of a novel proteomic Biomarker in Parkinson’s Disease: Discovery and Replication in Blood, brain and CSF
Identification of a novel proteomic Biomarker in Parkinson’s Disease: Discovery and Replication in Blood, brain and CSF Open
Biomarkers to aid diagnosis and delineate progression of Parkinson’s Disease (PD) are vital for targeting treatment in the early phases of disease. Here, we aim to discover a multi-protein panel representative of PD and make mechanistic in…
View article: Urinary metabolic phenotyping for Alzheimer’s disease
Urinary metabolic phenotyping for Alzheimer’s disease Open
Finding early disease markers using non-invasive and widely available methods is essential to develop a successful therapy for Alzheimer’s Disease. Few studies to date have examined urine, the most readily available biofluid. Here we repor…
View article: Cellular Phenotyping of Hippocampal Progenitors Exposed to Patient Serum Predicts Progression to Alzheimer's Disease
Cellular Phenotyping of Hippocampal Progenitors Exposed to Patient Serum Predicts Progression to Alzheimer's Disease Open
View article: Plasma Protein Biomarkers for the Prediction of CSF Amyloid and Tau and [18F]-Flutemetamol PET Scan Result
Plasma Protein Biomarkers for the Prediction of CSF Amyloid and Tau and [18F]-Flutemetamol PET Scan Result Open
Background: Blood biomarkers may aid in recruitment to clinical trials of Alzheimer’s disease (AD) modifying therapeutics by triaging potential trials participants for amyloid positron emission tomography (PET) or cerebrospinal fluid (CSF)…
View article: Biomarkers for Parkinson’s disease and Alzheimer’s disease
Biomarkers for Parkinson’s disease and Alzheimer’s disease Open
Alzheimer’s Disease (AD) and Parkinson’s Disease (PD) represent the two most prevalent neurodegenerative diseases in the world, affecting 30 million and 5 million people, respectively. As populations age, the global burden of AD and PD wil…
View article: Cellular phenotyping of hippocampal progenitors exposed to patient serum predicts conversion to Alzheimer’s Disease
Cellular phenotyping of hippocampal progenitors exposed to patient serum predicts conversion to Alzheimer’s Disease Open
The generation of new neurons persists into adulthood in the human hippocampus and can be modulated by the circulatory systemic environment. Hippocampal neurogenesis is important for learning and memory and is altered in Alzheimer’s Diseas…
View article: The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer’s pathology
The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer’s pathology Open
View article: Additional file 1: of The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimerâ s pathology
Additional file 1: of The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimerâ s pathology Open
Table presenting CSF proteins differentially expressed between IR and non-IR subjects (pâ
View article: Additional file 2: of The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimerâ s pathology
Additional file 2: of The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimerâ s pathology Open
Table presenting plasma proteins differentially expressed between IR and non-IR subjects (pâ
View article: Additional file 3: of The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimerâ s pathology
Additional file 3: of The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimerâ s pathology Open
Table presenting correlation results of CSF SOMAscan proteins with CSF markers of AD pathology (CSV 436 kb)
View article: Additional file 4: of The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimerâ s pathology
Additional file 4: of The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimerâ s pathology Open
Table presenting correlation results of plasma SOMAscan proteins with CSF markers of AD pathology (CSV 442 kb)
View article: Complement Biomarkers as Predictors of Disease Progression in Alzheimer’s Disease
Complement Biomarkers as Predictors of Disease Progression in Alzheimer’s Disease Open
There is a critical unmet need for reliable markers of disease and disease course in mild cognitive impairment (MCI) and early Alzheimer's disease (AD). The growing appreciation of the importance of inflammation in early AD has focused att…
View article: The medial prefrontal cortex is crucial for the maintenance of persistent licking and the expression of incentive contrast
The medial prefrontal cortex is crucial for the maintenance of persistent licking and the expression of incentive contrast Open
We examined the role of the medial prefrontal cortex (mPFC) in reward processing and the control of consummatory behavior. Rats were trained in an operant licking procedure in which they received alternating access to solutions with relati…