Martin R. Bennett
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View article: Artificial Intelligence-Led Whole Coronary Artery OCT Analysis; Validation and Identification of Drug Efficacy and Higher-Risk Plaques
Artificial Intelligence-Led Whole Coronary Artery OCT Analysis; Validation and Identification of Drug Efficacy and Higher-Risk Plaques Open
BACKGROUND: Intracoronary optical coherence tomography (OCT) can identify changes following drug/device treatment and high-risk plaques, but analysis requires expert clinician or core laboratory interpretation, while artifacts and limited …
View article: Delineation of a thrombin receptor-stimulated vascular smooth muscle cell transition generating cells in the plaque-stabilizing fibrous cap
Delineation of a thrombin receptor-stimulated vascular smooth muscle cell transition generating cells in the plaque-stabilizing fibrous cap Open
Aims Vascular smooth muscle cells (VSMCs) accumulate in atherosclerotic plaques and exhibit remarkable phenotypic plasticity, contributing to both plaque growth and stability. The plaque-stabilizing fibrous cap is rich in VSMC-derived cell…
View article: Premature cell senescence promotes vascular smooth muscle cell phenotypic modulation and resistance to re-differentiation
Premature cell senescence promotes vascular smooth muscle cell phenotypic modulation and resistance to re-differentiation Open
Aims Human atherosclerotic plaque cells display DNA damage that if left unrepaired can promote premature cell senescence. Vascular smooth muscle cells (VSMCs) predisposed to senescence promote atherogenesis and features of unstable plaques…
View article: Review and recommendations for using artificial intelligence in intracoronary optical coherence tomography analysis
Review and recommendations for using artificial intelligence in intracoronary optical coherence tomography analysis Open
Artificial intelligence (AI) tools hold great promise for the rapid and accurate diagnosis of coronary artery disease (CAD) from intravascular optical coherent tomography (IVOCT) images. Numerous papers have been published describing AI-ba…
View article: Review and Recommendations for using Artificial Intelligence in Intracoronary Optical Coherence Tomography Analysis
Review and Recommendations for using Artificial Intelligence in Intracoronary Optical Coherence Tomography Analysis Open
Artificial intelligence (AI) methodologies hold great promise for the rapid and accurate diagnosis of coronary artery disease (CAD) from intravascular optical coherent tomography (IVOCT) images. Numerous papers have been published describi…
View article: The role of exercise in bolstering cardiac resilience during aging
The role of exercise in bolstering cardiac resilience during aging Open
Aging leads to structural and functional deterioration of the heart, reducing its capacity to withstand internal and external stressors and consequently increasing the risk of heart failure. Exercise is a potent modulator of cardiovascular…
View article: Coronavirus disease 2019–related myocardial injury is associated with immune dysregulation in symptomatic patients with cardiac magnetic resonance imaging abnormalities
Coronavirus disease 2019–related myocardial injury is associated with immune dysregulation in symptomatic patients with cardiac magnetic resonance imaging abnormalities Open
Aims While acute cardiovascular complications of coronavirus disease 2019 (COVID-19) are well described, less is known about longer-term cardiac sequelae. For many individuals with cardiac signs or symptoms arising after COVID-19 infection…
View article: Evaluation of microcirculatory protection in percutaneous revascularisation: A stent implantation technique and device comparison
Evaluation of microcirculatory protection in percutaneous revascularisation: A stent implantation technique and device comparison Open
Background Coronary microvascular dysfunction (CMD) after percutaneous coronary intervention (PCI) is prognostically important and may also be a cause of persistent angina. The stent balloon inflation technique or material properties may i…
View article: Delineation of a thrombin receptor-stimulated vascular smooth muscle cell transition generating cells in the plaque-stabilising fibrous cap
Delineation of a thrombin receptor-stimulated vascular smooth muscle cell transition generating cells in the plaque-stabilising fibrous cap Open
Aims Vascular smooth muscle cells (VSMCs) accumulate in atherosclerotic plaques and exhibit remarkable phenotypic plasticity, contributing to both plaque growth and stability. The plaque-stabilising fibrous cap is rich in VSMC-derived cell…
View article: Network-based prioritization and validation of regulators of vascular smooth muscle cell proliferation in disease
Network-based prioritization and validation of regulators of vascular smooth muscle cell proliferation in disease Open
Aberrant vascular smooth muscle cell (VSMC) homeostasis and proliferation characterize vascular diseases causing heart attack and stroke. Here we elucidate molecular determinants governing VSMC proliferation by reconstructing gene regulato…
View article: Oxidative DNA damage promotes vascular ageing associated with changes in extracellular matrix-regulating proteins
Oxidative DNA damage promotes vascular ageing associated with changes in extracellular matrix-regulating proteins Open
Aims Vascular ageing is characterized by vessel stiffening, with increased deposition of extracellular matrix (ECM) proteins including collagens. Oxidative DNA damage occurs in vascular ageing, but how it regulates ECM proteins and vascula…
View article: Computed tomography pericoronary adipose tissue density predicts coronary allograft vasculopathy and adverse clinical outcomes after cardiac transplantation
Computed tomography pericoronary adipose tissue density predicts coronary allograft vasculopathy and adverse clinical outcomes after cardiac transplantation Open
Aims To assess pericoronary adipose tissue (PCAT) density on coronary computed tomography angiography (CCTA) as a marker of inflammatory disease activity in coronary allograft vasculopathy (CAV). Methods and results PCAT density, lesion vo…
View article: Loss of T follicular regulatory cell-derived IL-1R2 augments germinal centre reactions via increased IL-1
Loss of T follicular regulatory cell-derived IL-1R2 augments germinal centre reactions via increased IL-1 Open
Inappropriate immune activity is key in the pathogenesis of multiple diseases, and it is typically driven by excess inflammation and/or autoimmunity. IL-1 is often the effector owing to its powerful role in both innate and adaptive immunit…
View article: Comprehensive biomechanical and anatomical atherosclerotic plaque metrics predict major adverse cardiovascular events: A new tool for clinical decision making
Comprehensive biomechanical and anatomical atherosclerotic plaque metrics predict major adverse cardiovascular events: A new tool for clinical decision making Open
Combining complementary biomechanical and anatomical metrics significantly improves risk-stratification of individual coronary lesions. If confirmed from larger prospective studies, our results may inform targeted revascularisation vs. con…
View article: CT pericoronary adipose tissue density predicts coronary allograft vasculopathy and adverse clinical outcomes after cardiac transplantation
CT pericoronary adipose tissue density predicts coronary allograft vasculopathy and adverse clinical outcomes after cardiac transplantation Open
Background Coronary allograft vasculopathy (CAV) is a common cause of heart transplant failure. Coronary Computed Tomography Angiography (CCTA) is used to assess for luminal stenoses in patients with suspected CAV, but additional non-invas…
View article: Multimodality imaging and immunophenotyping of COVID-19 related myocardial injury (the MIIC-MI Study)
Multimodality imaging and immunophenotyping of COVID-19 related myocardial injury (the MIIC-MI Study) Open
Background Cardiac injury is a well-recognised complication of acute COVID-19 infection, with varied aetiologies ranging from myocarditis to endothelial dysfunction, micro-embolic phenomena, and acute coronary syndromes. While persistent c…
View article: Network-based prioritisation and validation of novel regulators of vascular smooth muscle cell proliferation in disease
Network-based prioritisation and validation of novel regulators of vascular smooth muscle cell proliferation in disease Open
Aberrant vascular smooth muscle cell (VSMC) homeostasis and proliferation are hallmarks of vascular diseases causing heart attack and stroke. To elucidate molecular determinants governing VSMC proliferation, we reconstructed gene regulator…
View article: Thrombin-activated interleukin-1α drives atherogenesis, but also promotes vascular smooth muscle cell proliferation and collagen production
Thrombin-activated interleukin-1α drives atherogenesis, but also promotes vascular smooth muscle cell proliferation and collagen production Open
Aims Atherosclerosis is driven by multiple processes across multiple body systems. For example, the innate immune system drives both atherogenesis and plaque rupture via inflammation, while coronary artery-occluding thrombi formed by the c…
View article: Characteristics of conventional high-risk coronary plaques and a novel CT defined thin-cap fibroatheroma in patients undergoing CCTA with stable chest pain
Characteristics of conventional high-risk coronary plaques and a novel CT defined thin-cap fibroatheroma in patients undergoing CCTA with stable chest pain Open
The novel CT-TCFA is associated with MACE and has improved inter-observer variability compared with current CT-defined high-risk plaques.
View article: Heterogeneous plaque–lumen geometry is associated with major adverse cardiovascular events
Heterogeneous plaque–lumen geometry is associated with major adverse cardiovascular events Open
Aims Prospective studies show that only a minority of plaques with higher risk features develop future major adverse cardiovascular events (MACE), indicating the need for more predictive markers. Biomechanical estimates such as plaque stru…
View article: Editorial: Computational modeling for assessing coronary artery pathophysiology
Editorial: Computational modeling for assessing coronary artery pathophysiology Open
EDITORIAL article Front. Cardiovasc. Med., 17 January 2023Sec. Cardiovascular Imaging Volume 10 - 2023 | https://doi.org/10.3389/fcvm.2023.1113835
View article: Novel Approach for Assessing Postinfarct Myocardial Injury and Inflammation Using Hybrid Somatostatin Receptor Positron Emission Tomography/Magnetic Resonance Imaging
Novel Approach for Assessing Postinfarct Myocardial Injury and Inflammation Using Hybrid Somatostatin Receptor Positron Emission Tomography/Magnetic Resonance Imaging Open
Post-infarct inflammation and its resolution modulate ischemic injury after myocardial infarction (MI). While cardiac magnetic resonance imaging (MRI) is useful for assessing ventricular function, viability and structural complications aft…