Bennian Huo
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View article: Physiologically Based Pharmacokinetic Modeling and Dose Optimization of Linezolid in Pediatric Patients With Renal Impairment
Physiologically Based Pharmacokinetic Modeling and Dose Optimization of Linezolid in Pediatric Patients With Renal Impairment Open
Our model provides a predictive instrument to enhance precision in determining therapeutic LZD dosage regimens for pediatric populations through systematic integration of developmental PK parameters.
View article: Clinical drug interactions between voriconazole and 38 other drugs: a retrospective analysis of adverse events
Clinical drug interactions between voriconazole and 38 other drugs: a retrospective analysis of adverse events Open
Background Voriconazole (VRZ) is involved in a variety of drug‒drug interactions (DDIs), but few studies have reported adverse events (AEs) associated with the DDIs of VRZ. The primary goal of this study was to analyse the potential risk f…
View article: Clinical drug interactions between linezolid and other antibiotics: For adverse drug event monitoring
Clinical drug interactions between linezolid and other antibiotics: For adverse drug event monitoring Open
Detailed data on safety associated with drug–drug interactions (DDIs) between Linezolid (LZD) and other antibiotics are limited. The aim of this study was to investigate the safety signals related to these DDIs and to provide a reference f…
View article: Quality assessment of paediatric randomized controlled trials published in China from 1999 to 2022: a cross-sectional study
Quality assessment of paediatric randomized controlled trials published in China from 1999 to 2022: a cross-sectional study Open
Background Randomized controlled trials (RCTs) are usually the basis of evidence-based medicine, but whether the results of RCTs can be correctly translated into clinical practice depends on the quality of the literature reported. In this …
View article: Relationship Between Linezolid Exposure and the Typical Clinical Laboratory Safety and Bacterial Clearance in Chinese Pediatric Patients
Relationship Between Linezolid Exposure and the Typical Clinical Laboratory Safety and Bacterial Clearance in Chinese Pediatric Patients Open
Objectives: There have been limited studies concerning the safety and efficacy of linezolid (LZD) in children. This study aimed to evaluate the association between LZD exposure and clinical safety and efficacy in Chinese pediatric patients…
View article: Current situation of pediatric clinical trials in China: focus on trials for drug marketing application and administrative approval
Current situation of pediatric clinical trials in China: focus on trials for drug marketing application and administrative approval Open
View article: General characteristics and reasons for the discontinuation of drug clinical trials in mainland China
General characteristics and reasons for the discontinuation of drug clinical trials in mainland China Open
View article: Current Situation of Clinical Trials of Drugs for Children's Indications in China
Current Situation of Clinical Trials of Drugs for Children's Indications in China Open
Background: The number of pediatric outpatient visits in the general hospitals of China shows an increasing trend year by year. To analyze the current situation of clinical trials of drugs with indications for children in China in order to…
View article: General Characteristics and Reasons for the Discontinuation of Drug Clinical Trials in Mainland China
General Characteristics and Reasons for the Discontinuation of Drug Clinical Trials in Mainland China Open
Background: Although discontinuation is common in clinical trials, no study has been conducted to analyse the current situation and reasons for the suspension or discontinuation of drug clinical trials in China. This study aims to analyse …
View article: General Characteristics and Quality Assessment of Pediatric Randomized Controlled Trials Published in Mainland China over the Decades 1999-2018
General Characteristics and Quality Assessment of Pediatric Randomized Controlled Trials Published in Mainland China over the Decades 1999-2018 Open
Objective : Randomized controlled trials (RCTs) are usually the basis of evidence-based medicine and provide important information for pediatric clinical practice, but whether the results of RCTs can be correctly translated into clinical p…