Benno Meier
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Signal averaging in cryogenic fast field-cycling NMR experiments Open
The spin-lattice relaxation time constant T1 characterizes the equilibration of a spin system in a magnetic field with its environment, the lattice. T1 frequently exhibits non-trivial field and temperature dependences, which give access to…
Nuclear magnetic resonance far off the Larmor frequency: Nonsecular resonances in Open
High field magnetic resonance of nuclear spins is normally carried out at or near the Larmor frequency Ω0. Here, we report an observation of nonsecular nuclear spin resonances far off Ω0. These originate from nonsecular terms of the nuclea…
Higher Contrast in <sup>1</sup>H‐Observed NMR Ligand Screening with the PEARLScreen Experiment Open
For initial hit identification in fragment‐based drug design, NMR is one of the preferred methods, with the well‐established ligand screening experiments T 1ρ , waterLOGSY and STD. Here, we present a new, perfect echo‐based experiment with…
Hyperpolarization and sensitivity in nuclear magnetic resonance Open
Hyperpolarization can boost the sensitivity of nuclear magnetic resonance. Other things being equal, a polarization increase by one order of magnitude leads to a time saving by two orders of magnitude. However, other things are rarely equa…
Short-lived calcium carbonate precursors observed in situ via Bullet-dynamic nuclear polarization Open
The discovery of (meta)stable pre-nucleation species (PNS) challenges the established nucleation-and-growth paradigm. While stable PNS with long lifetimes are readily accessible experimentally, identifying and characterizing early-stage in…
Bullet-DNP Enables NMR Spectroscopy of Pyruvate and Amino Acids at Nanomolar to Low Micromolar Concentrations Open
Hyperpolarized pyruvate is a widely used marker to track metabolism in vivo and a benchmark molecule for hyperpolarization methods. Here, we show how a combination of improved bullet-DNP instrumentation, an optimized sample preparation and…
Hyperpolarization of Long-Lived States of Protons in Aliphatic Chains by Bullet Dynamic Nuclear Polarization, Revealed on the Fly by Spin-Lock-Induced Crossing Open
It is shown that proton spins highly polarized by dynamic nuclear polarization (DNP) retain substantial polarization upon the rapid transfer of frozen bullets from a polarizer to an NMR spectrometer. After injection in solution, the result…
Long-lived enhanced magnetization—A practical metabolic MRI contrast material Open
Noninvasive tracking of biochemical processes in the body is paramount in diagnostic medicine. Among the leading techniques is spectroscopic magnetic resonance imaging (MRI), which tracks metabolites with an amplified (hyperpolarized) magn…
View article: Selective Peptide Binders to the Perfluorinated Sulfonic Acid Ionomer Nafion (Adv. Funct. Mater. 20/2024)
Selective Peptide Binders to the Perfluorinated Sulfonic Acid Ionomer Nafion (Adv. Funct. Mater. 20/2024) Open
Nafion Selective non-covalent binding to technical polymers opens avenues for innovative fuel cell membrane design at the molecular level. In article number 2214932, Patrizia Gartner, Alexander Nesterov-Mueller, and co-workers introduce a …
Biphasic NMR of Hyperpolarized Suspensions─Real-Time Monitoring of Solute-to-Solid Conversion to Watch Materials Grow Open
Nuclear magnetic resonance (NMR) spectroscopy is a key method for the determination of molecular structures. Due to its intrinsically high (i.e., atomistic) resolution and versatility, it has found numerous applications for investigating g…
View article: Selective Peptide Binders to the Perfluorinated Sulfonic Acid Ionomer Nafion
Selective Peptide Binders to the Perfluorinated Sulfonic Acid Ionomer Nafion Open
Fuel cells used for transport applications hold polymer membranes as a key element. Their efficiency can be significantly increased if structured ion channels are implemented at the molecular level into the proton‐conducting membrane. New …
Radical-Induced Low-Field <sup>1</sup>H Relaxation in Solid Pyruvic Acid Doped with Trityl-OX063 Open
In dynamic nuclear polarization (DNP), radicals such as trityl provide a source for high nuclear spin polarization. Conversely, during the low-field transfer of hyperpolarized solids, the radicals' dipolar or Non-Zeeman reservoir may act a…
Radical-induced Hetero-Nuclear Mixing and Low-field $^{13}$C Relaxation in Solid Pyruvic Acid Open
Radicals serve as source in dynamic nuclear polarization, but may also act as polarization sink. If the coupling between the electron spins and different nuclear reservoirs is stronger than any of the reservoirs' couplings to the lattice, …
Radical-induced hetero-nuclear mixing and low-field <sup>13</sup>C relaxation in solid pyruvic acid Open
Radicals are a polarization source in dynamic nuclear polarization at high field, but are known to act as polarization sink at low field. Here we show that at intermediate fields radicals can facilitate hetero-nuclear 1 H– 13 C polarizatio…
A cryogen-free, semi-automated apparatus for bullet-dynamic nuclear polarization with improved resolution Open
In dissolution-dynamic nuclear polarization, a hyperpolarized solid is dissolved with a jet of hot solvent. The solution is then transferred to a secondary magnet, where spectra can be recorded with improved sensitivity. In bullet-dynamic …
Comment on mr-2021-57 Open
Abstract. In dissolution-dynamic nuclear polarization, a hyperpolarized solid is dissolved with a jet of hot solvent. The solution is then transferred to a secondary magnet, where spectra can be recorded with improved sensitivity. In bulle…
Comment on mr-2021-57 Open
Abstract. In dissolution-dynamic nuclear polarization, a hyperpolarized solid is dissolved with a jet of hot solvent. The solution is then transferred to a secondary magnet, where spectra can be recorded with improved sensitivity. In bulle…
Comment on mr-2021-51 Open
Abstract. Among hyperpolarization techniques, quantum-rotor-induced polarization (QRIP), also known as the Haupt effect, is a peculiar one. It is, on the one hand, rather simple to apply by cooling and heating a sample. On the other hand, …
A cryogen-free, semi-automated apparatus for bullet-dynamic nuclear polarization with improved resolution Open
In dissolution-dynamic nuclear polarization, a hyperpolarized solid is dissolved with a jet of hot solvent. The solution is then transferred to a secondary magnet, where spectra can be recorded with improved sensitivity. In bullet-dynamic …
Dataset for Scalable Dissolution-Dynamic Nuclear Polarization with Rapid Transfer of a Polarized Solid Open
Unprocessed NMR data, oscilloscope traces, and time-dependent temperature data as shown in Nature Communications manuscript: Karel Kouril, Hana Kourilova, Samuel Bartram, Malcolm H Levitt, Benno Meier 'Scalable Dissolution-Dynamic Nuclear …
Hyperpolarized long-lived nuclear spin states in monodeuterated methyl groups Open
Dissolution-dynamic nuclear polarization is implemented to hyperpolarize long-lived nuclear spin states in monodeuterated methyl groups.
NMR Lineshapes and Scalar Relaxation of the Water‐Endofullerene H<sub>2</sub><sup>17</sup>O@C<sub>60</sub> Open
The 17 O isotopomer of the water‐endofullerene H 2 O@C 60 displays a remarkable proton NMR spectrum, with six well resolved peaks. These peaks are due to the J ‐coupling between the water protons and the 17 O nucleus, which has spin‐5/2. T…
Dynamic Nuclear Polarization of Long-Lived Nuclear Spin States in Methyl Groups Open
We have induced hyperpolarized long-lived states in compounds containing 13C-bearing methyl groups by dynamic nuclear polarization (DNP) at cryogenic temperatures, followed by dissolution with a warm solvent. The hyperpolarized methyl long…
CCDC 1453465: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …