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View article: AI-Based Retinal Image Analysis for the Detection of Choroidal Neovascular Age-Related Macular Degeneration (AMD) and Its Association with Brain Health
AI-Based Retinal Image Analysis for the Detection of Choroidal Neovascular Age-Related Macular Degeneration (AMD) and Its Association with Brain Health Open
Purpose: This study aims to develop a method for detecting referable (intermediate and advanced) age-related macular degeneration (AMD) and neovascular AMD, as well as providing an automatic segmentation of choroidal neovascularisation (CN…
View article: A protection motivation theory-guided telehealth coaching program for middle-aged adults with cardiometabolic risk: A feasibility trial
A protection motivation theory-guided telehealth coaching program for middle-aged adults with cardiometabolic risk: A feasibility trial Open
Background Health coaching to address the escalated cardiometabolic risk in middle-aged adults in primary health care is underexplored. This study aimed to examine the feasibility and acceptability of a protection motivation theory-guided …
View article: Comparison of macular thickness in diabetic patients acquired from optical coherence tomography mode and optical coherence tomography angiography mode in Cirrus HD-OCT 5000
Comparison of macular thickness in diabetic patients acquired from optical coherence tomography mode and optical coherence tomography angiography mode in Cirrus HD-OCT 5000 Open
Improved fixation in OCTA compared with OCT was evident, likely because of the faster scanning speed and higher sampling density of OCTA. Macular thickness was found similar. There appears no requirement to obtain macular thickness measure…
View article: Automatic retinal image analysis methods using colour fundus images for screening glaucomatous optic neuropathy
Automatic retinal image analysis methods using colour fundus images for screening glaucomatous optic neuropathy Open
Objectives Train an automatic retinal image analysis (ARIA) method to screen glaucomatous optic neuropathy (GON) on non-mydriatic retinal images labelled with the additional results of optical coherence tomography (OCT) and assess differen…
View article: Projection of dengue fever transmissibility under climate change in South and Southeast Asian countries
Projection of dengue fever transmissibility under climate change in South and Southeast Asian countries Open
Vector-borne infectious disease such as dengue fever (DF) has spread rapidly due to more suitable living environments. Considering the limited studies investigating the disease spread under climate change in South and Southeast Asia, this …
View article: Predictive evolutionary modelling for influenza virus by site-based dynamics of mutations
Predictive evolutionary modelling for influenza virus by site-based dynamics of mutations Open
Influenza virus continuously evolves to escape human adaptive immunity and generates seasonal epidemics. Therefore, influenza vaccine strains need to be updated annually for the upcoming flu season to ensure vaccine effectiveness. We devel…
View article: Genetic association of COVID-19 severe versus non-severe cases by RNA sequencing in patients hospitalised in Hong Kong
Genetic association of COVID-19 severe versus non-severe cases by RNA sequencing in patients hospitalised in Hong Kong Open
RNA sequencing analysis showed that severe acute respiratory syndrome coronavirus 2 infection is associated with the overexpression of genes involved in nervous system disorders.
View article: Multi-domain neurocognitive impairment following definitive intensity-modulated radiotherapy for nasopharyngeal cancer: A cross-sectional study
Multi-domain neurocognitive impairment following definitive intensity-modulated radiotherapy for nasopharyngeal cancer: A cross-sectional study Open
Neurocognitive impairment is prevalent and profound in post-IMRT NPC survivors. Cognitive assessment and rehabilitation should be considered part of survivorship care.
View article: Early detection of nasopharyngeal carcinoma: performance of a short contrast-free screening magnetic resonance imaging
Early detection of nasopharyngeal carcinoma: performance of a short contrast-free screening magnetic resonance imaging Open
Background Although contrast-enhanced magnetic resonance imaging (MRI) detects early-stage nasopharyngeal carcinoma (NPC) not detected by endoscopic-guided biopsy (EGB), a short contrast-free screening MRI would be desirable for NPC screen…
View article: Predictive evolutionary modelling for influenza virus by site-based dynamics of mutations
Predictive evolutionary modelling for influenza virus by site-based dynamics of mutations Open
A predictive evolutionary model was developed to forecast representative influenza viral strains and select vaccine strains for upcoming epidemic seasons. Influenza virus continuously evolves to escape human adaptive immunity and generates…
View article: Corrigendum: Ischemic and haemorrhagic stroke risk estimation using a machine-learning-based retinal image analysis
Corrigendum: Ischemic and haemorrhagic stroke risk estimation using a machine-learning-based retinal image analysis Open
[This corrects the article DOI: 10.3389/fneur.2022.916966.].
View article: A New Model Selection Metric for Biomarker Detection Algorithms and Tools
A New Model Selection Metric for Biomarker Detection Algorithms and Tools Open
In the era of precision medicine, biomarker plays a vital role in drug clinical trials. It helps select the patients more likely to respond to the therapy and increases the possibility of success of the trial. Model selection is critical i…
View article: An efficient approach to estimate the risk of coronary artery disease for people living with HIV using machine-learning-based retinal image analysis
An efficient approach to estimate the risk of coronary artery disease for people living with HIV using machine-learning-based retinal image analysis Open
Background People living with HIV (PLWH) have increased risks of non-communicable diseases, especially cardiovascular diseases. Current HIV clinical management guidelines recommend regular cardiovascular risk screening, but the risk equati…
View article: Improving in silico prediction of influenza vaccine effectiveness by genome analysis incorporating epitope information
Improving in silico prediction of influenza vaccine effectiveness by genome analysis incorporating epitope information Open
Fast evaluation of vaccine effectiveness (VE) is valuable for facilitating vaccine development and making vaccination strategy. In previous studies, we developed the computational model linking molecular variations and VE for the influenza…
View article: Lifestyle Changes Reduced Estimated White Matter Hyperintensities Based on Retinal Image Analysis
Lifestyle Changes Reduced Estimated White Matter Hyperintensities Based on Retinal Image Analysis Open
This study evaluates if there is an association between lifestyle changes and the risk of small vessel disease (SVD) as measured by cerebral white matter hyperintensities (WMH) estimated by the automatic retinal image analysis (ARIA) metho…
View article: Digital solution for detection of undiagnosed diabetes using machine learning-based retinal image analysis
Digital solution for detection of undiagnosed diabetes using machine learning-based retinal image analysis Open
Introduction Undiagnosed diabetes is a global health issue. Previous studies have estimated that about 24.1%–75.1% of all diabetes cases are undiagnosed, leading to more diabetic complications and inducing huge healthcare costs. Many curre…
View article: A Prism Vote method for individualized risk prediction of traits in genotype data of Multi-population
A Prism Vote method for individualized risk prediction of traits in genotype data of Multi-population Open
Multi-population cohorts offer unprecedented opportunities for profiling disease risk in large samples, however, heterogeneous risk effects underlying complex traits across populations make integrative prediction challenging. In this study…
View article: Ischemic and haemorrhagic stroke risk estimation using a machine-learning-based retinal image analysis
Ischemic and haemorrhagic stroke risk estimation using a machine-learning-based retinal image analysis Open
Background Stroke is the second leading cause of death worldwide, causing a considerable disease burden. Ischemic stroke is more frequent, but haemorrhagic stroke is responsible for more deaths. The clinical management and treatment are di…
View article: Health Disparity Resulting from the Effect of Built Environment on Temperature-Related Mortality in a Subtropical Urban Setting
Health Disparity Resulting from the Effect of Built Environment on Temperature-Related Mortality in a Subtropical Urban Setting Open
Whereas previous studies have assessed the overall health impact of temperature in Hong Kong, the aim of this study was to investigate whether the health impact is modified by local temperature of small geographic units, which may be relat…
View article: Risk Assessment of CHD Using Retinal Images with Machine Learning Approaches for People with Cardiometabolic Disorders
Risk Assessment of CHD Using Retinal Images with Machine Learning Approaches for People with Cardiometabolic Disorders Open
Background: Coronary heart disease (CHD) is the leading cause of death worldwide, constituting a growing health and social burden. People with cardiometabolic disorders are more likely to develop CHD. Retinal image analysis is a novel and …
View article: Improved risk stratification of nasopharyngeal cancer by targeted sequencing of Epstein–Barr virus DNA in post-treatment plasma
Improved risk stratification of nasopharyngeal cancer by targeted sequencing of Epstein–Barr virus DNA in post-treatment plasma Open
NPC prognostication using post-treatment plasma EBV DNA could be enhanced through sequencing.
View article: Spatiotemporal relationship between temperature and non-accidental mortality: Assessing effect modification by socioeconomic status
Spatiotemporal relationship between temperature and non-accidental mortality: Assessing effect modification by socioeconomic status Open
This study indicated that the daily fluctuation of mortality was associated with daily temperature, while the spatial variation of mortality within this city could be explained by the geographical distribution of green space and socioecono…
View article: A Prism Vote Framework for Individualized Risk Prediction of Traits in Genome-wide Sequencing Data of Multiple Populations
A Prism Vote Framework for Individualized Risk Prediction of Traits in Genome-wide Sequencing Data of Multiple Populations Open
Multi-population cohorts offer unprecedented opportunities for profiling disease risk in large samples, however, heterogeneous risk effects underlying complex traits across populations make integrative prediction challenging. In this study…
View article: Quantifying the effect of government interventions and virus mutations on transmission advantage during COVID-19 pandemic
Quantifying the effect of government interventions and virus mutations on transmission advantage during COVID-19 pandemic Open
Our study provided a convenient framework to estimate the effect of genetic contribution and government interventions on pathogen transmissibility. We showed that the S, N and ORF1b protein had significant contribution to the increase of t…
View article: Temporal Patterns in the Evolutionary Genetic Distance of SARS-CoV-2 during the COVID-19 Pandemic
Temporal Patterns in the Evolutionary Genetic Distance of SARS-CoV-2 during the COVID-19 Pandemic Open
During coronavirus disease 2019 (COVID-19) pandemic, the genetic mutations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurred frequently. Some mutations in the spike protein are considered to promote transmissibility …