Benoit Allegrini
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View article: Cancer-associated loss-of-function mutations in KCNQ1 enhance Wnt/β-catenin signalling disrupting epithelial homeostasis
Cancer-associated loss-of-function mutations in KCNQ1 enhance Wnt/β-catenin signalling disrupting epithelial homeostasis Open
View article: RSPO1, a potent inducer of pancreatic β cell neogenesis
RSPO1, a potent inducer of pancreatic β cell neogenesis Open
Inducing the neogenesis of pancreatic insulin-producing β cells holds great promise for diabetes research. However, non-toxic compounds with such activities remain to be discovered. Herein, we report the identification of RSPO1, a key agon…
View article: A new regulation mechanism for KCNN4, the Ca2+-dependent K+ channel, by molecular interactions with the Ca2+pump PMCA4b
A new regulation mechanism for KCNN4, the Ca2+-dependent K+ channel, by molecular interactions with the Ca2+pump PMCA4b Open
View article: Rôle de l'interaction entre PIEZO1 et KCNN4 dans la pathophysiologie érythrocytaire
Rôle de l'interaction entre PIEZO1 et KCNN4 dans la pathophysiologie érythrocytaire Open
The red blood cell (RBC) is the most abundant cell in the human body and is responsible for oxygen et carbon dioxide transport while it is lacking nucleus and organelles. During its 120-day lifespan, the RBC undergoes over 200,000 passages…
View article: Pharmacological activation of PIEZO1 in human red blood cells prevents Plasmodium falciparum invasion
Pharmacological activation of PIEZO1 in human red blood cells prevents Plasmodium falciparum invasion Open
View article: SK2 channels set a signalling hub bolstering CAF-triggered tumourigenic processes in pancreatic cancer
SK2 channels set a signalling hub bolstering CAF-triggered tumourigenic processes in pancreatic cancer Open
Objective Intercellular communication within pancreatic ductal adenocarcinoma (PDAC) dramatically contributes to metastatic processes. The underlying mechanisms are poorly understood, resulting in a lack of targeted therapy to counteract s…
View article: New KCNN4 Variants Associated With Anemia: Stomatocytosis Without Erythrocyte Dehydration
New KCNN4 Variants Associated With Anemia: Stomatocytosis Without Erythrocyte Dehydration Open
The K + channel activated by the Ca 2+ , KCNN4, has been shown to contribute to red blood cell dehydration in the rare hereditary hemolytic anemia, the dehydrated hereditary stomatocytosis. We report two de novo mutations on KCNN4 , We rep…
View article: Hereditary Xerocytosis: Differential Behavior of PIEZO1 Mutations in the N-Terminal Extracellular Domain Between Red Blood Cells and HEK Cells
Hereditary Xerocytosis: Differential Behavior of PIEZO1 Mutations in the N-Terminal Extracellular Domain Between Red Blood Cells and HEK Cells Open
Hereditary Xerocytosis, a rare hemolytic anemia, is due to gain of function mutations in PIEZO1, a non-selective cation channel activated by mechanical stress. How these PIEZO1 mutations impair channel function and alter red blood cell (RB…
View article: Piezo1 and BKCa channels in human atrial fibroblasts: interplay and remodelling in atrial fibrillation
Piezo1 and BKCa channels in human atrial fibroblasts: interplay and remodelling in atrial fibrillation Open
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Ministry of Science, Research and Arts Baden-Württemberg (MWK-BW Sonderlinie Medizin) Atrial Fibrillation (AF) is an arrhythm…
View article: Interplay Between Ion Channels and the Wnt/β-Catenin Signaling Pathway in Cancers
Interplay Between Ion Channels and the Wnt/β-Catenin Signaling Pathway in Cancers Open
Increasing evidence point out the important roles of ion channels in the physiopathology of cancers, so that these proteins are now considered as potential new therapeutic targets and biomarkers in this disease. Indeed, ion channels have b…