Explanipedia

ECOSBot: a multicenter validation pilot study of a generative AI tool for OSCE-based nephrology training Open

Raphaël Bentegeac, Nans Florens, Mehdi Maanaoui, Valentin Maisons, Antoine Lanot , et al. · 2025

Background Developing diagnostic reasoning in nephrology is particularly challenging due to its pathophysiological complexity and reliance on abstract clinical data. Objective Structured Clinical Examinations (OSCEs) are pivotal for nephro…

Outcomes After Kidney Transplantation in Antineutrophil Cytoplasmic Autoantibody–Associated Renal Vasculitis Open

Marine Dekervel, Priscille Traversat, Philippe Gatault, Léonard Golbin, Antoine Thierry , et al. · 2025

Although KT offers patients with AAV-GN short-term outcomes similar to controls, they face higher long-term risk of graft failure and mortality. ANCA status at transplantation may help predict immunological events, emphasizing the need for…

Outcomes After Kidney Transplantation in Antiglomerular Basement Membrane Disease Open

Priscille Traversat, Marine Dekervel, Christophe Masset, Dominique Bertrand, Léonard Golbin , et al. · 2025

Kidney Transplantation Improves Survival in Antineutrophil Cytoplasmic Antibody–Associated Vasculitides With End-Stage Kidney Disease Open

Benoît Brilland, Jean‐François Augusto, Thomas Jouvé, Noémie Jourde‐Chiche, Cécile Couchoud · 2025

Kidney Transplantation Improves Survival in Lupus Nephritis With End-Stage Kidney Disease Open

Benoît Brilland, Jean‐François Augusto, P.A. Michel, Noémie Jourde‐Chiche, Cécile Couchoud · 2025

Plasma Exchange for Severe Alveolar Hemorrhage in ANCA-Associated Vasculitis: Emulation of a Target Trial Open

A. Sanna, Ségolène Gendreau, Cyrielle Desnos, Dimitri Titeca‐Beauport, Jolan Malherbe , et al. · 2025

#1154 Type I interferon pathway is upregulated in microscopic polyangiitis (vs granulomatosis with polyangiitis) Open

Benoît Brilland, Andréa Boizard-Moracchini, Nathalie Tortevoie, Giorgina Barbara Piccoli, Patrick Blanco , et al. · 2024

Background and Aims The two main types of ANCA-associated vasculitis (AAV), microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA), share common characteristics but also differ on many aspects (epidemiological, genetic, …

#1121 Identification of kidney transcripts associated with prognosis in ANCA-associated glomerulonephritis Open

Benoît Brilland, Jérémie Riou, Andréa Boizard-Moracchini, Nathalie Tortevoie, Giorgina Barbara Piccoli , et al. · 2024

Background and Aims Kidney involvement in ANCA-associated vasculitis (AAV-GN) predicts poor patient and kidney survival. Deciphering the transcriptomic landscape in AAV-GN may provide insights into pathogenic mechanisms or identify biomark…

#1156 Outcomes after kidney transplantation in ANCA-associated vasculitis Open

Benoît Brilland, Marine Dekervel, Priscille Traversat, Giorgina Barbara Piccoli, Nicolás Henry , et al. · 2024

Background and Aims ANCA-associated vasculitis with glomerulonephritis (AAV-GN) can lead to end-stage kidney disease (ESKD), requiring replacement therapy with dialysis or kidney transplant (KT). Few large studies evaluated the outcome of …

#1155 Outcomes after kidney transplantation in anti-glomerular basement membrane disease Open

Benoît Brilland, Priscille Traversat, Marine Dekervel, Giorgina Barbara Piccoli, Djema Assia , et al. · 2024

Background and Aims Anti-glomerular basement membrane antibody disease-associated glomerulonephritis (anti-GBM-GN) can lead to end-stage kidney disease (ESKD), requiring replacement therapy with dialysis or kidney transplant (KT). Few stud…

Adding 6-month parameters for the prediction of kidney prognosis in ANCA-associated glomerulonephritis Open

Charlotte Boud’hors, Jérémie Riou, Nicolas Fage, Clément Samoreau, Alice Desouche , et al. · 2023

Background Antineutrophil-cytoplasmic antibody (ANCA)-associated vasculitis (AAV) with kidney involvement (AAV-GN) frequently evolves to end-stage kidney disease (ESKD) despite aggressive immunosuppressive treatment. Several risk scores ha…

#4027 KIDNEY INJURY MOLECULE 1 (KIM-1): A POTENTIAL BIOMARKER OF ACUTE KIDNEY INJURY AND TUBULOINTERSTITIAL INJURY IN PATIENTS WITH ANCA-GLOMERULONEPHRITIS Open

Benoît Brilland, Charlotte Boud’hors, Samuel Wacrenier, Simon Blanchard, Jérôme Cayon , et al. · 2023

Background and Aims Kidney injury molecule 1 (KIM-1) is a transmembrane glycoprotein expressed by proximal tubular cells, recognized as an early, sensitive, and specific urinary biomarker for kidney injury. Blood KIM-1 was recently associa…

#4803 ANCA RENAL RISK SCORE 2023: THE UPDATED AND REVISED ARRS Open

Sebastian Bate, Dominic McGovern, Francesca Costigliolo, Marek Mysliveček, Jennifer Scott , et al. · 2023

Background and Aims Reliable prediction tools are needed to improve prognostication and personalisation of treatment in anti-neutrophil cytoplasmic antibody (ANCA) glomerulonephritides (GN). We aimed to validate and update the ANCA Renal R…

#4006 ADDING 6-MONTH PARAMETERS FOR THE PREDICTION OF RENAL PROGNOSIS IN ANCA-ASSOCIATED GLOMERULONEPHRITIS Open

Charlotte Boud’hors, Jérémie Riou, Nicolas Fage, Clément Samoreau, Alice Desouche , et al. · 2023

Background and Aims Antineutrophil-cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) with kidney involvement (AAV-GN) frequently evolves to end-stage kidney disease (ESKD) despite aggressive immunosuppressive treatment. Several ris…

Kidney injury molecule 1 (KIM-1): a potential biomarker of acute kidney injury and tubulointerstitial injury in patients with ANCA-glomerulonephritis Open

Benoît Brilland, Charlotte Boud’hors, Samuel Wacrenier, Simon Blanchard, Jérôme Cayon , et al. · 2023

Background Kidney injury molecule 1 (KIM-1) is a transmembrane glycoprotein expressed by proximal tubular cells, recognized as an early, sensitive and specific urinary biomarker for kidney injury. Blood KIM-1 was recently associated with t…

Assessment of an oocyte retrieval simulation training program for residents: from training to clinical practice Open

Pierre‐Emmanuel Bouet, Amélie Watelet, Benoît Brilland, Hady El Hachem, Pascale May‐Panloup · 2023

Objective: To assess the impact of an oocyte retrieval simulation training program (ORSTP) on the clinical performance of residents. Design: Prospective comparative study. Setting: A tertiary care center. Population: All OR performed by re…

Predictive Scores for Early Identification of Immune-Mediated Thrombotic Thrombocytopenic Purpura: Room for Improvement? Open

Adrien Joseph, Benoît Brilland, Laure Burguet, Martin Eloit, Nicolas Fage , et al. · 2022

Assessment of Renal Risk Score and Histopathological Classification for Prediction of End-Stage Kidney Disease and Factors Associated With Change in eGFR After ANCA-Glomerulonephritis Diagnosis Open

Benoît Brilland, Charlotte Boud’hors, Marie‐Christine Copin, Pierre Jourdain, Nicolás Henry , et al. · 2022

Introduction The “Renal Risk Score” (RRS) and the histopathological classification have been proposed to predict the risk of end-stage kidney disease (ESKD) in ANCA-associated glomerulonephritis (ANCA-GN). Besides, factors associated with …

Proteinuria Increases the PLASMIC and French Scores Performance to Predict Thrombotic Thrombocytopenic Purpura in Patients With Thrombotic Microangiopathy Syndrome Open

Nicolas Fage, Corentin Orvain, Nicolás Henry, Chloé Mellaza, François Beloncle , et al. · 2021

Low Complement C3 Levels at Diagnosis of ANCA-Associated Glomerulonephritis, a Specific Subset of Patients to Target With Anti-C5aR Therapy? Open

Benoît Brilland, Samuel Wacrenier, Nicolás Henry, Fanny Guibert, Giorgina Barbara Piccoli , et al. · 2021

Commentary: Outcome Predictors of Biopsy-Proven Myeloperoxidase-Anti-Neutrophil Cytoplasmic Antibody-Associated Glomerulonephritis Open

Samuel Wacrenier, Charlotte Boud’hors, Giorgina Barbara Piccoli, Jean‐François Augusto, Benoît Brilland · 2021

International audience

Serum Interleukin-26 Is a New Biomarker for Disease Activity Assessment in Systemic Lupus Erythematosus Open

Benoît Brilland, Maxime Bach-Bunner, Christopher Nunes Gomes, Vincent Larochette, Etienne Foucher , et al. · 2021

Objective Interleukin-26 (IL-26) has a unique ability to activate innate immune cells due to its binding to circulating double-stranded DNA. High levels of IL-26 have been reported in patients with chronic inflammation. We aimed to investi…

Retrospective and Systematic Analysis of Causes and Outcomes of Thrombotic Microangiopathies in Routine Clinical Practice: An 11-Year Study Open

Nicolás Henry, Chloé Mellaza, Nicolas Fage, François Beloncle, Franck Geneviève , et al. · 2021

Background: Thrombotic microangiopathies (TMAs) are highly suspected in patients showing mechanical hemolytic anemia, thrombocytopenia, and haptoglobin consumption. Primary [thrombotic thrombocytopenic purpura (TTP) and atypical hemolytic …

Anti-Pentraxin Antibodies in Autoimmune Diseases: Bystanders or Pathophysiological Actors? Open

Benoît Brilland, Emeline Vinatier, Jean‐François Subra, Pascale Jeannin, Jean‐François Augusto , et al. · 2021

Pentraxins are soluble innate immunity receptors involved in sensing danger molecules. They are classified as short (CRP, SAP) and long pentraxin subfamilies, including the prototypic long pentraxin PTX3. Pentraxins act mainly as bridging …

Incidence and Temporal Trend in Risk Factors of Severe Infections in ANCA-Glomerulonephritis Patients Open

Pierre Jourdain, Benoît Brilland, Ouassim Medhioub, Jeanne Caron, Clément Samoreau , et al. · 2021

Incidence and Risk Factors of Venous Thromboembolic Events in Patients with ANCA-Glomerulonephritis: A Cohort Study from the Maine-Anjou Registry Open

Nicolás Henry, Benoît Brilland, Samuel Wacrenier, Assia Djema, Anne Sophie Garnier , et al. · 2020

(1) Introduction: The incidence of venous thromboembolisms (VTE) has not been extensively analyzed in patients with antineutrophil cytoplasmic antibody (ANCA)-glomerulonephritis (ANCA-GN). Thus, the aim of the present study was to assess t…

High Incidence of Amoxicillin-Induced Crystal Nephropathy in Patients Receiving High Dose of Intravenous Amoxicillin Open

Anne‐Sophie Garnier, Juliette Dellamaggiore, Benoît Brilland, Laurence Lagarce, P. Abgueguen , et al. · 2020

Background: Amoxicillin (AMX)-induced crystal nephropathy (AICN) is considered as a rare complication of high dose intravenous (IV) AMX administration. However, recently, its incidence seems to be increasing based on French pharmacovigilan…

T Cell Dysregulation in Non-silicotic Silica Exposed Workers: A Step Toward Immune Tolerance Breakdown Open

Benoît Brilland, Céline Beauvillain, Gery Mazurkiewicz, P. Rucay, Yves Roquelaure , et al. · 2019

Background: Chronic silica exposure can lead to silicosis, complicated or not by autoimmune diseases (AID). The pathophysiology of silica-induced AID remains not fully understood, especially immune mechanisms that may develop in pat…

Patients with ANCA-Associated Glomerulonephritis and Connective Tissue Diseases: A Comparative Study from the Maine-Anjou AAV Registry Open

Fanny Guibert, Anne‐Sophie Garnier, Samuel Wacrenier, Giorgina Barbara Piccoli, Assia Djema , et al. · 2019

Background and objectives: The overlap between antineutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis (ANCA-GN) and connective tissue diseases (CTD) has been reported mainly as case series in the literature. Frequency of …

CD45RC Expression of Circulating CD8+ T Cells Predicts Acute Allograft Rejection: A Cohort Study of 128 Kidney Transplant Patients Open

Marie Lemerle, Anne‐Sophie Garnier, Martin Planchais, Benoît Brilland, Yves Delneste , et al. · 2019

Predictive biomarkers of acute rejection (AR) are lacking. Pre-transplant expression of CD45RC on blood CD8+ T cells has been shown to predict AR in kidney transplant (KT) patients. The objective of the present study was to study CD45RC ex…

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