Benoît Foligné
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Changes in HLA-B27 Transgenic Rat Fecal Microbiota Following Tofacitinib Treatment and Ileocecal Resection Surgery: Implications for Crohn’s Disease Management Open
The therapeutic management of Crohn’s disease (CD), a chronic relapsing–remitting inflammatory bowel disease (IBD), is highly challenging. Surgical resection is sometimes a necessary procedure even though it is often associated with postop…
View article: An Overview of the Influence of Breastfeeding on the Development of Inflammatory Bowel Disease
An Overview of the Influence of Breastfeeding on the Development of Inflammatory Bowel Disease Open
The first 1000 days of life is a critical period that contributes significantly to the programming of an individual’s future health. Among the many changes that occur during this period early in life, there is growing evidence that the est…
Extracellular Vesicles and Surface Layer Proteins as the post-biotic active ingredient of the probiotic bacterium Propionibacterium freudenreichii against colitis and mucositis Open
International audience
View article: An Overview of the Influence of Breastfeeding on the Developement of Inflammatory Bowel Disease
An Overview of the Influence of Breastfeeding on the Developement of Inflammatory Bowel Disease Open
The first 1000 days of life is a critical period that contributes significantly to the programming of an individual's future health. Among the many changes that occur during this period, there is growing evidence that the establishment of …
Beneficial propionibacteria: from traditional cheeses to next generation probiotics Open
International audience
<i>Saccharomyces cerevisiae </i>prevents postoperative recurrence of Crohn's disease modeled by ileocecal resection in HLA-B27 transgenic rats Open
In a reliable model of POR induced by LF82 in TgB27 rats, CNCM I-3856 prevents macroscopic POR by decreasing LF82 infection and gut inflammation.
View article: Study of the persistence and dynamics of recombinant <scp>mCherry</scp> ‐producing <i>Yarrowia lipolytica</i> strains in the mouse intestine using fluorescence imaging
Study of the persistence and dynamics of recombinant <span>mCherry</span> ‐producing <i>Yarrowia lipolytica</i> strains in the mouse intestine using fluorescence imaging Open
Yarrowia lipolytica is a dimorphic oleaginous non‐conventional yeast widely used as a powerful host for expressing heterologous proteins, as well as a promising source of engineered cell factories for various applications. This microorgani…
View article: A Unique Enhancement of Propionibacterium freudenreichii’s Ability to Remove Pb(II) from Aqueous Solution by Tween 80 Treatment
A Unique Enhancement of Propionibacterium freudenreichii’s Ability to Remove Pb(II) from Aqueous Solution by Tween 80 Treatment Open
Microbial agents have promise for the bioremediation of Pb(II)-polluted environments and wastewater, the biodecontamination of foods, and the alleviation of toxicity in living organisms. The dairy bacterium Propionibacterium freudenreichii…
Safety and Efficacy of an AIEC-targeted Bacteriophage Cocktail in a Mice Colitis Model Open
Background and aims Adherent invasive Escherichia coli [AIEC] are recovered with a high frequency from the gut mucosa of Crohn’s disease patients and are believed to contribute to the dysbiosis and pathogenesis of this inflammatory bowel d…
TOFACITINIB TREATMENT PREVENTS POST-OPERATIVE RECURRENCE OF CROHN’S DISEASE MODELED BY ILEOCECAL RESECTION IN HLA-B27 TRANSGENIC RATS Open
BACKGROUND Post-operative recurrence (POR) after ileocecal resection (ICR) affects most of Crohn’s disease (CD) patients within 3-5 years after surgery. Current immunomodulatory treatments have not proven efficiency in preventing POR, exce…
View article: Underlying evidence for the health benefits of fermented foods in humans
Underlying evidence for the health benefits of fermented foods in humans Open
Fermented foods (FFs) have been a part of our diets for millennia and comprise highly diverse products obtained from plants and animals all over the world: Mechanisms of action and impact of health status.
P602 Tofacitinib treatment prevents post-operative recurrence of Crohn’s Disease modeled by ileocecal resection in HLA-B27 transgenic rats Open
Background Post-operative recurrence (POR) after ileocecal resection (ICR) affects most of Crohn’s disease (CD) patients. Immunomodulatory treatments have not proven efficiency in preventing POR except for anti-TNFα biologic agents. We eva…
View article: Adherent-Invasive and Non-Invasive Escherichia coli Isolates Differ in Their Effects on Caenorhabditis elegans’ Lifespan
Adherent-Invasive and Non-Invasive Escherichia coli Isolates Differ in Their Effects on Caenorhabditis elegans’ Lifespan Open
The adherent-invasive Escherichia coli (AIEC) pathotype has been implicated in the pathogenesis of inflammatory bowel diseases in general and in Crohn’s disease (CD) in particular. AIEC strains are primarily characterized by their ability …
Influenza Virus Infection Impairs the Gut’s Barrier Properties and Favors Secondary Enteric Bacterial Infection through Reduced Production of Short-Chain Fatty Acids Open
Along with respiratory tract disease per se , viral respiratory infections can also cause extrapulmonary complications with a potentially critical impact on health. In the present study, we used an experimental model of influenza A virus (…
View article: Assessment of Pb(II), Cd(II), and Al(III) Removal Capacity of Bacteria from Food and Gut Ecological Niches: Insights into Biodiversity to Limit Intestinal Biodisponibility of Toxic Metals
Assessment of Pb(II), Cd(II), and Al(III) Removal Capacity of Bacteria from Food and Gut Ecological Niches: Insights into Biodiversity to Limit Intestinal Biodisponibility of Toxic Metals Open
Toxic metals (such as lead, cadmium, and, to a lesser extent, aluminum) are detrimental to health when ingested in food or water or when inhaled. By interacting with heavy metals, gut and food-derived microbes can actively and/or passively…
View article: Assessment of Pb(II), Cd(II) and Al(III) Removal Capacity of Bacteria From Food and Gut Ecological Niches: Insights Into Biodiversity to Limit Intestinal Biodisponibility of Toxic Metals
Assessment of Pb(II), Cd(II) and Al(III) Removal Capacity of Bacteria From Food and Gut Ecological Niches: Insights Into Biodiversity to Limit Intestinal Biodisponibility of Toxic Metals Open
Hazardous toxic metals, such as lead and cadmium, and to a lesser extent aluminum, are extensively recognized as detrimental for health following ingestion within food and water, or following inhalation. Gut and food-derived microbes, by i…
View article: Persistence and dynamics of fluorescent <i>Lactobacillus plantarum</i> in the healthy <i>versus</i> inflamed gut
Persistence and dynamics of fluorescent <i>Lactobacillus plantarum</i> in the healthy <i>versus</i> inflamed gut Open
The gastrointestinal tract is the main ecological niche in which Lactobacillus strains may provide health benefits in mammals. There is currently a need to characterize host-microbe interactions in space and time by tracking these bacteria…
View article: Contribution of the Gut Microbiota in P28GST-Mediated Anti-Inflammatory Effects: Experimental and Clinical Insights
Contribution of the Gut Microbiota in P28GST-Mediated Anti-Inflammatory Effects: Experimental and Clinical Insights Open
An original immuno-regulatory strategy against inflammatory bowel diseases based on the use of 28 kDa glutathione S-transferase (P28GST), a unique schistosome protein, was recently proposed. Improvement of intestinal inflammation occurs th…
Occurrence and Dynamism of Lactic Acid Bacteria in Distinct Ecological Niches: A Multifaceted Functional Health Perspective Open
Lactic acid bacteria (LAB) are representative members of multiple ecosystems on earth, displaying dynamic interactions within animal and plant kingdoms in respect with other microbes. This highly heterogeneous phylogenetic group has coevol…
Chicory Roots for Prebiotics and Appetite Regulation: A Pilot Study in Mice Open
The objectives of this work are to address the prebiotic effects of chicory ( Cichorium intybus) together with its possible role in appetite control. We compared nine chicory genotypes in order to determine if variations in the content of …
Healthy gut microbiota can resolve undernutrition Open
Child’s undernutrition is widely recognized as a major public health issue in many low- and middle-income countries.
Local Treatment with Lactate Prevents Intestinal Inflammation in the TNBS-Induced Colitis Model Open
Lactate has long been considered as a metabolic by-product of cells. Recently, this view has been changed by the observation that lactate can act as a signaling molecule and regulates critical functions of the immune system. We previously …
Flagellin-Mediated Protection against Intestinal Yersinia pseudotuberculosis Infection Does Not Require Interleukin-22 Open
Signaling through Toll-like receptors (TLRs), the main receptors in innate immunity, is essential for the defense of mucosal surfaces. It was previously shown that systemic TLR5 stimulation by bacterial flagellin induces an immediate, tran…