Benoit Lehallier
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View article: Infusion of young donor plasma components in older patients modifies the immune and inflammatory response to surgical tissue injury: a randomized clinical trial
Infusion of young donor plasma components in older patients modifies the immune and inflammatory response to surgical tissue injury: a randomized clinical trial Open
View article: Development, characterization, and replication of proteomic aging clocks: Analysis of 2 population-based cohorts
Development, characterization, and replication of proteomic aging clocks: Analysis of 2 population-based cohorts Open
Background Biological age may be estimated by proteomic aging clocks (PACs). Previous published PACs were constructed either in smaller studies or mainly in white individuals, and they used proteomic measures from only one-time point. In t…
View article: Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson’s disease
Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson’s disease Open
View article: Proteomic profiles of cytokines and chemokines in moderate to severe depression: Implications for comorbidities and biomarker discovery
Proteomic profiles of cytokines and chemokines in moderate to severe depression: Implications for comorbidities and biomarker discovery Open
View article: Organ aging signatures in the plasma proteome track health and disease
Organ aging signatures in the plasma proteome track health and disease Open
View article: Interactome‐guided machine learning modeling reveals information embedded in blood plasma protein‐protein interactions in Alzheimer’s Disease patients treated by the complex plasma fraction GRF6019
Interactome‐guided machine learning modeling reveals information embedded in blood plasma protein‐protein interactions in Alzheimer’s Disease patients treated by the complex plasma fraction GRF6019 Open
Background The relevance of plasma fraction treatment to reverse age‐related conditions was underlined by our previous pre‐clinical results. In two Phase 2 clinical trials (GRF6019‐201 and GRF6019‐202), patients with Alzheimer’s Disease (A…
View article: Network propagation unveils molecular mechanisms modulated in Alzheimer’s Disease patients treated by the complex plasma fraction GRF6019
Network propagation unveils molecular mechanisms modulated in Alzheimer’s Disease patients treated by the complex plasma fraction GRF6019 Open
Background Our pre‐clinical work provided evidence of the interest of plasma fraction treatment to reverse age‐related cognitive decline. One of the most potent plasma fractions, GRF6019 was tested on patients with Alzheimer’s disease (AD)…
View article: Modulation of inflammatory regulation by plasma exchange with albumin replacement revealed by deep plasma and CSF proteomic profiling of the AMBAR study
Modulation of inflammatory regulation by plasma exchange with albumin replacement revealed by deep plasma and CSF proteomic profiling of the AMBAR study Open
Background AMBAR trial (phase 2b/3 clinical trial) evaluates plasma exchange efficacy with albumin replacement (PE‐Alb) in mild‐to‐moderate Alzheimer’s Disease (AD) patients. It includes an intensive period (IP) comprising 6‐weeks of conve…
View article: Nowhere to run, nowhere to hide ‐ targeting the immune system in AD with multimodal plasma therapeutics
Nowhere to run, nowhere to hide ‐ targeting the immune system in AD with multimodal plasma therapeutics Open
Background Age‐related diseases, especially Alzheimer’s Disease (AD), have multifaceted nature because of the different factors and pathways contributing to these diseases. Multi‐modal plasma therapies have the potential to impact multiple…
View article: Cerebrospinal Fluid Proteomic Changes after Nusinersen in Patients with Spinal Muscular Atrophy
Cerebrospinal Fluid Proteomic Changes after Nusinersen in Patients with Spinal Muscular Atrophy Open
Disease-modifying treatments have transformed the natural history of spinal muscular atrophy (SMA), but the cellular pathways altered by SMN restoration remain undefined and biomarkers cannot yet precisely predict treatment response. We pe…
View article: Proteomic architecture of frailty across the spectrum of cardiovascular disease
Proteomic architecture of frailty across the spectrum of cardiovascular disease Open
While frailty is a prominent risk factor in an aging population, the underlying biology of frailty is incompletely described. Here, we integrate 979 circulating proteins across a wide range of physiologies with 12 measures of frailty in a …
View article: Development and Characterization of Proteomic Aging Clocks in the Atherosclerosis Risk in Communities (ARIC) Study
Development and Characterization of Proteomic Aging Clocks in the Atherosclerosis Risk in Communities (ARIC) Study Open
Biological age may be estimated by proteomic aging clocks (PACs). Previous published PACs were constructed either in smaller studies or mainly in White individuals, and they used proteomic measures from only one-time point. In the Atherosc…
View article: Atlas of the aging mouse brain reveals white matter as vulnerable foci
Atlas of the aging mouse brain reveals white matter as vulnerable foci Open
View article: An <i>IL1RL1</i> genetic variant lowers soluble ST2 levels and the risk effects of <i>APOE</i>‐ε4 in Alzheimer’s disease
An <i>IL1RL1</i> genetic variant lowers soluble ST2 levels and the risk effects of <i>APOE</i>‐ε4 in Alzheimer’s disease Open
Background Genetic factors are increasingly being recognized as important contributors to the pathogenesis of Alzheimer’s disease (AD). While the expression of most AD risk genes is enriched in microglia, which leads to microglial dysfunct…
View article: Markers of aging: Unsupervised integrated analyses of the human plasma proteome
Markers of aging: Unsupervised integrated analyses of the human plasma proteome Open
Aging associates with an increased susceptibility for disease and decreased quality of life. To date, processes underlying aging are still not well understood, leading to limited interventions with unknown mechanisms to promote healthy agi…
View article: Author Correction: Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17
Author Correction: Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17 Open
View article: Aromatic L-Amino Acid Decarboxylase is a novel fluid biomarker of Parkinson’s disease
Aromatic L-Amino Acid Decarboxylase is a novel fluid biomarker of Parkinson’s disease Open
There are currently limited molecular markers of Parkinson’s disease, and there is an urgent need for new markers to guide clinical care, support earlier diagnosis, and hasten drug development. Here, we performed CSF and plasma proteomics …
View article: A spatiotemporal map of the aging mouse brain reveals white matter tracts as vulnerable foci
A spatiotemporal map of the aging mouse brain reveals white matter tracts as vulnerable foci Open
Summary Aging is the key risk factor for cognitive decline, yet the molecular changes underlying brain aging remain poorly understood. Here, we conducted spatiotemporal RNA-seq of the mouse brain, profiling 1,076 samples from 15 regions ac…
View article: Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17
Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17 Open
View article: Molecular hallmarks of heterochronic parabiosis at single-cell resolution
Molecular hallmarks of heterochronic parabiosis at single-cell resolution Open
View article: A Spatiotemporal Map of the Aging Mouse Brain Reveals White Matter Tracts as Vulnerable Foci
A Spatiotemporal Map of the Aging Mouse Brain Reveals White Matter Tracts as Vulnerable Foci Open
View article: Exercise plasma boosts memory and dampens brain inflammation via clusterin
Exercise plasma boosts memory and dampens brain inflammation via clusterin Open
View article: Deep Longitudinal Proteomics Profiling Reveals Biological Pathways Responding to GRF6019 in Two AD Clinical Trials
Deep Longitudinal Proteomics Profiling Reveals Biological Pathways Responding to GRF6019 in Two AD Clinical Trials Open
Blood has been widely investigated to discover biomarkers and gain insights into the biology of aging and age-related diseases. Its protein composition provides insights into complex biological processes, as proteins are often direct regul…
View article: Author Correction: An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging
Author Correction: An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging Open
View article: An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging
An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging Open
View article: A neuronal blood marker is associated with mortality in old age
A neuronal blood marker is associated with mortality in old age Open
Neurofilament light chain (NfL) has emerged as a promising blood biomarker for the progression of various neurological diseases. NfL is a structural protein of nerve cells and elevated levels in blood are thought to mirror damage t…
View article: A neuronal blood marker is associated with mortality in old age
A neuronal blood marker is associated with mortality in old age Open
View article: Methods to investigate intrathecal adaptive immunity in neurodegeneration
Methods to investigate intrathecal adaptive immunity in neurodegeneration Open
View article: Methods to investigate intrathecal adaptive immunity in neurodegeneration
Methods to investigate intrathecal adaptive immunity in neurodegeneration Open
Background: Cerebrospinal fluid (CSF) provides basic mechanical and immunological protection to the brain. Historically, analysis of CSF has focused on protein changes, yet recent studies have shed light on cellular alterations. Evidence n…
View article: Elucidating emerging therapeutics: P75 receptor modulation reverts tauopathy associated alterations in synapse‐relevant gene expression signatures
Elucidating emerging therapeutics: P75 receptor modulation reverts tauopathy associated alterations in synapse‐relevant gene expression signatures Open
Background In tauopathy mouse models, activity‐dependent synaptic plasticity, as measured by long‐term potentiation (LTP), is compromised. Treatment of tauopathy mice with LM11A‐31, a small molecule modulator of p75 neurotrophin receptor s…