Benoît Lengelé
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View article: Surgical mechanical properties of perfused decellularized massive bone allografts: An comparative in vivo test
Surgical mechanical properties of perfused decellularized massive bone allografts: An comparative in vivo test Open
Massive bone allograft decellularized by perfusion is a solution for large bone defect reconstructions. Perfusion-based decellularization offers a solution by removing cellular components while preserving the non-immunogenic matrix. This s…
View article: Preexpanded Perforator Flaps for Neoesophageal Reconstruction after Bipolar Upper Gastrointestinal Tract Exclusion
Preexpanded Perforator Flaps for Neoesophageal Reconstruction after Bipolar Upper Gastrointestinal Tract Exclusion Open
Background: Total esophageal reconstruction after failure of conventional techniques is a significant surgical challenge, particularly in fragile patients who have undergone multiple surgical procedures. Traditional options, including gast…
View article: Beneath the perforators: Unravelling fascia lata intrinsic vascular architecture using microfocus X-ray computed tomography
Beneath the perforators: Unravelling fascia lata intrinsic vascular architecture using microfocus X-ray computed tomography Open
This study unveils the intrinsic vascularization of the FL, supporting its utility as a mega-thin vascularized flap in reconstructive surgery. Based on this vascular carrier, these findings also open new applications for tissue engineering…
View article: <scp>2D</scp> and <scp>3D</scp> microstructural analysis of the iliotibial tract
<span>2D</span> and <span>3D</span> microstructural analysis of the iliotibial tract Open
The fascial system has gained recognition for its integral role in connecting skin, superficial and deep fasciae, and underlying muscles. However, consensus on its microstructure depending on its topography remains elusive as well as its i…
View article: HLA Awareness in tissue decellularization: A paradigm shift for enhanced biocompatibility, studied on the model of the human fascia lata graft
HLA Awareness in tissue decellularization: A paradigm shift for enhanced biocompatibility, studied on the model of the human fascia lata graft Open
Last twenties, tissue engineering has rapidly advanced to address the shortage of organ donors. Decellularization techniques have been developed to mitigate immune rejection and alloresponse in transplantation. However, a clear definition …
View article: Impact of NaOH based perfusion-decellularization protocol on mechanical resistance of structural bone allografts
Impact of NaOH based perfusion-decellularization protocol on mechanical resistance of structural bone allografts Open
Descriptive statistical results suggest a tendency for the biomechanical characteristics of decellularized bone to decrease compared with the control group. However, statistical inferences demonstrated a slight significant superiority of t…
View article: Collagen molecular organization preservation in human fascia lata and periosteum after tissue engineering
Collagen molecular organization preservation in human fascia lata and periosteum after tissue engineering Open
Large bone defect regeneration remains a major challenge for orthopedic surgeons. Tissue engineering approaches are therefore emerging in order to overcome this limitation. However, these processes can alter some of essential native tissue…
View article: Reconstruction of the human nipple–areolar complex: a tissue engineering approach
Reconstruction of the human nipple–areolar complex: a tissue engineering approach Open
Introduction: Nipple–areolar complex (NAC) reconstruction after breast cancer surgery is challenging and does not always provide optimal long-term esthetic results. Therefore, generating a NAC using tissue engineering techniques, such as a…
View article: Pyoderma gangrenosum with severe systemic features, after augmentation mammoplasty
Pyoderma gangrenosum with severe systemic features, after augmentation mammoplasty Open
We report a rare life‐threatening presentation of postsurgical pyoderma gangrenosum (PG) after augmentation mammoplasty in a 32‐year‐old woman. Six days after surgery, the patient presented with fever and erythema at surgical wounds. In vi…
View article: Decellularization of Massive Bone Allografts By Perfusion: A New Protocol for Tissue Engineering
Decellularization of Massive Bone Allografts By Perfusion: A New Protocol for Tissue Engineering Open
In terms of large bone defect reconstructions, massive bone allografts may sometimes be the only solution. However, they are still burdened with a high postoperative complication rate. Our hypothesis is that the immunogenicity of residual …
View article: International consensus recommendations on face transplantation: A 2-step Delphi study
International consensus recommendations on face transplantation: A 2-step Delphi study Open
Face transplantation is a viable reconstructive approach for severe craniofacial defects. Despite the evolution witnessed in the field, ethical aspects, clinical and psychosocial implications, public perception, and economic sustainability…
View article: 3D histopathology of stenotic aortic valve cusps using ex vivo microfocus computed tomography
3D histopathology of stenotic aortic valve cusps using ex vivo microfocus computed tomography Open
Background Calcific aortic stenosis (AS) is the most prevalent heart valve disease in developed countries. The aortic valve cusps progressively thicken and the valve does not open fully due to the presence of calcifications. In vivo imagin…
View article: MASSIVE BONE ALLOGRAFT DECELLULARIZATION BY A PERFUSION PROTOCOL SET UP FOR A BIOCOMPATIBLE MODEL
MASSIVE BONE ALLOGRAFT DECELLULARIZATION BY A PERFUSION PROTOCOL SET UP FOR A BIOCOMPATIBLE MODEL Open
The purpose of this study is to enhance massive bone allografts osseointegration used to reconstruct large bone defects. These allografts show >50% complication rate requiring surgical revision in 20% cases. A new protocol for total bone d…
View article: A New Osteogenic Membrane to Enhance Bone Healing: At the Crossroads between the Periosteum, the Induced Membrane, and the Diamond Concept
A New Osteogenic Membrane to Enhance Bone Healing: At the Crossroads between the Periosteum, the Induced Membrane, and the Diamond Concept Open
The lack of viability of massive bone allografts for critical-size bone defect treatment remains a challenge in orthopedic surgery. The literature has reviewed the advantages of a multi-combined treatment with the synergy of an osteoconduc…
View article: Decellularized vascularized bone grafts: A preliminary in vitro porcine model for bioengineered transplantable bone shafts
Decellularized vascularized bone grafts: A preliminary in vitro porcine model for bioengineered transplantable bone shafts Open
Introduction : Durable reconstruction of critical size bone defects is still a surgical challenge despite the availability of numerous autologous and substitute bone options. In this paper, we have investigated the possibility of creating …
View article: Measurements and morphometric landmarks of the human spinal cord: A cadaveric study
Measurements and morphometric landmarks of the human spinal cord: A cadaveric study Open
The topographical neuroanatomy of the human spinal cord (SC) is currently based on the adjacent vertebrae. This morphometric study sought to develop a dataset allowing for statistical analysis of human SC segment characteristics. Overall, …
View article: Decellularized vascularized bone grafts as therapeutic solution for bone reconstruction: A mechanical evaluation
Decellularized vascularized bone grafts as therapeutic solution for bone reconstruction: A mechanical evaluation Open
Introduction Large bone defects are challenging for surgeons. Available reimplanted bone substitutes can’t properly restore optimal function along and long term osteointegration of the bone graft. Bone substitute based on the perfusion-dec…
View article: Periosteum and fascia lata: Are they so different?
Periosteum and fascia lata: Are they so different? Open
Introduction: The human fascia lata (HFL) is used widely in reconstructive surgery in indications other than fracture repair. The goal of this study was to compare microscopic, molecular, and mechanical properties of HFL and periosteum (HP…
View article: Update on the role of caveolin-1 in cell homeostasis and oxidative stress in hashimoto's thyroiditis and graves' disease
Update on the role of caveolin-1 in cell homeostasis and oxidative stress in hashimoto's thyroiditis and graves' disease Open
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
View article: miR-199a Downregulation as a Driver of the NOX4/HIF-1α/VEGF-A Pathway in Thyroid and Orbital Adipose Tissues from Graves′ Patients
miR-199a Downregulation as a Driver of the NOX4/HIF-1α/VEGF-A Pathway in Thyroid and Orbital Adipose Tissues from Graves′ Patients Open
Graves’ disease (GD) is an autoimmune thyroiditis often associated with Graves’ orbitopathy (GO). GD thyroid and GO orbital fat share high oxidative stress (OS) and hypervascularization. We investigated the metabolic pathways leading to OS…
View article: Perforator-Based Intercostal Artery Muscle Flap: A Novel Approach for the Treatment of Tracheoesophageal or Bronchoesophageal Fistulas
Perforator-Based Intercostal Artery Muscle Flap: A Novel Approach for the Treatment of Tracheoesophageal or Bronchoesophageal Fistulas Open
Summary: Postoperative tracheoesophageal or bronchoesophageal fistulas represent a major surgical challenge. The authors report the description of an original perforator-based intercostal artery muscle flap, aiming to cover all types of in…
View article: Oxidative Stress-Induced Sirtuin1 Downregulation Correlates to HIF-1α, GLUT-1, and VEGF-A Upregulation in Th1 Autoimmune Hashimoto’s Thyroiditis
Oxidative Stress-Induced Sirtuin1 Downregulation Correlates to HIF-1α, GLUT-1, and VEGF-A Upregulation in Th1 Autoimmune Hashimoto’s Thyroiditis Open
In Hashimoto’s thyroiditis (HT), oxidative stress (OS) is driven by Th1 cytokines’ response interfering with the normal function of thyrocytes. OS results from an imbalance between an excessive production of reactive oxygen species (ROS) a…