Explanipedia

The gut insulin receptor acts as gatekeeper of intestinal barrier integrity Open

Dalale Gueddouri, Florian Sicherre, Michèle Caüzac, Adele Caudron-Hedeline, Fadila Benhamed , et al. · 2025

An impaired gut barrier has emerged as a potential driver of the low-grade inflammation that accompanies obesity and its complications. Among these, hyperglycemia per se has been proposed to sustain such increased intestinal permeability a…

CLONAL LYMPHOCYTE EXPANSIONS AND JAK-STAT PATHWAY MUTATIONS DEFINE A PATHOGENIC CONTINUUM DRIVING RESISTANCE TO GLUTEN-FREE DIET IN CELIAC DISEASE Open

Georgia Malamut, Nicolas Guégan, Francesco Carbone, Cécile Masson, Marine Luka , et al. · 2025

Background&Aims Despite recent advances, refractory celiac disease (RCD) poses challenging questions. In type 2 RCD (RCD2), the lack of response to the gluten-free diet is attributed to an intestinal intraepithelial lymphoma carrying drive…

ACBP/DBI neutralization for the experimental treatment of fatty liver disease Open

Omar Motiño, Flavia Lambertucci, Adrien Joseph, Sylvère Durand, Gerasimos Anagnostopoulos , et al. · 2024

Acyl-CoA binding protein (ACBP), also known as diazepam-binding inhibitor (DBI), is an extracellular checkpoint of autophagy. Here, we report that patients with histologically confirmed metabolic-associated steatohepatitis (MASH) or liver …

A macrophage-smooth muscle cell axis influences vascular remodeling through activation of the EGFR pathway in giant cell arteritis Open

Kévin Chevalier, Léa Dionet, Paul Breillat, Margot Poux, Julien Dang , et al. · 2024

Background. The role of macrophages and vascular resident cells appears to be predominant in the pathophysiology of giant cell arteritis (GCA). We investigated the role of epithelial growth factor receptor (EGFR) signaling pathway, especia…

Impact of hydroxyurea on follicle density in patients with sickle cell disease Open

Tamara Diesch, Carlos Sanchez, Andrew Atkinson, Corinne Pondarré, Nathalie Dhédin , et al. · 2024

The impact of hydroxyurea (HU) on the ovarian reserve of female patients with sickle cell disease (SCD) remains poorly elucidated. Only direct histological analysis of ovarian follicle density can effectively evaluate HU’s effect on ovaria…

Comment on “How Does Omitting Additional Surgery After Local Excision Affect the Prognostic Outcome of Patients With High-Risk T1 Colorectal Cancer?” Open

Stanislas Chaussade, Félix Corre, Anna Pellat, Romain Coriat, Benoît Terris · 2024

We read with interest the paper from Akira Ouchi et al1 on behalf of the study group for the JSCCR-T. This study is important since the JSCCR criteria for additional surgical resection after local excision of a T1 colorectal cancer (CRC) a…

Burden of grade 3 or 4 liver injury associated with immune checkpoint inhibitors Open

Lucia Parlati, Mehdi Sakka, A. Retbi, Samir Bouam, L. Hassani , et al. · 2023

There is concern about liver injury in patients with cancer exposed to immune checkpoints inhibitors (ICIs). We investigated the burden of grade 3/4 liver injury after treatment with ICIs in a multicentric cohort of patients with cancer. O…

Histological Characteristics and Management of Hepatitis on Immune Checkpoint Inhibitors: A Retrospective Descriptive Study Open

Lucia Parlati, Kennie Marcin, Benoît Terris, Anaïs Vallet‐Pichard, Marion Corouge , et al. · 2023

Background and aims: the side effects of immune checkpoint inhibitors (ICI) pose a problem for the clinical management of cancer patients. There is a lack of knowledge of the value of liver biopsy in patients with ICI-related drug-induced …

Azathioprine‐induced vanishing bile duct syndrome: The value of early thiopurine metabolism assessment Open

Laurent Chouchana, Benoît Terris, Philippe Sogni, Jean‐Marc Tréluyer, N. Costedoat‐Chalumeau , et al. · 2023

About 15% to 28% of patients treated with thiopurines experienced adverse drug reactions, such as haematological and hepatic toxicities. Some of these related to the polymorphic activity of the thiopurine S‐methyltransferase (TPMT), the ke…

Impact of induction therapy in locally advanced intrahepatic cholangiocarcinoma Open

Alix Dhote, Stylianos Tzedakis, Christian Hobeika, Ugo Marchèse, Romain Coriat , et al. · 2023

High Prevalence of NASH and Advanced Fibrosis in Type 2 Diabetes: A Prospective Study of 330 Outpatients Undergoing Liver Biopsies for Elevated ALT, Using a Low Threshold Open

Laurent Castéra, Cédric Laouénan, Anaïs Vallet‐Pichard, Tiphaine Vidal-Trécan, Pauline Manchon , et al. · 2023

OBJECTIVE Most people with type 2 diabetes (T2DM) and nonalcoholic steatohepatitis (NASH) or advanced fibrosis remain undiagnosed, resulting in missed opportunities for early intervention. This multicenter prospective st…

High Prevalence of NASH and Advanced Fibrosis in Type 2 Diabetes: A Prospective Study of 330 Outpatients Undergoing Liver Biopsies for Elevated ALT, Using a Low Threshold Open

Laurent Castéra, Cédric Laouénan, Anaïs Vallet‐Pichard, Tiphaine Vidal-Trécan, Pauline Manchon , et al. · 2023

OBJECTIVE Most people with type 2 diabetes (T2DM) and nonalcoholic steatohepatitis (NASH) or advanced fibrosis (AF) remain undiagnosed, resulting in missed opportunities for early intervention. This multicenter, prospective study assessed …

High Prevalence of NASH and Advanced Fibrosis in Type 2 Diabetes: A Prospective Study of 330 Outpatients Undergoing Liver Biopsies for Elevated ALT, Using a Low Threshold Open

Laurent Castéra, Cédric Laouénan, Anaïs Vallet‐Pichard, Tiphaine Vidal-Trécan, Pauline Manchon , et al. · 2023

OBJECTIVE Most people with type 2 diabetes (T2DM) and nonalcoholic steatohepatitis (NASH) or advanced fibrosis remain undiagnosed, resulting in missed opportunities for early intervention. This multicenter prospective st…

Data from Gene Expression Profiling Provides Insights into Pathways of Oxaliplatin-Related Sinusoidal Obstruction Syndrome in Humans Open

Laura Rubbia‐Brandt, Sébastien Tauzin, Catherine Brézault, Céline Delucinge-Vivier, Patrick Descombes , et al. · 2023

Sinusoidal obstruction syndrome (SOS; formerly veno-occlusive disease) is a well-established complication of hematopoietic stem cell transplantation, pyrrolizidine alkaloid intoxication, and widely used chemotherapeutic agents such as oxal…

Supplementary Tables 1-7 from Gene Expression Profiling Provides Insights into Pathways of Oxaliplatin-Related Sinusoidal Obstruction Syndrome in Humans Open

Laura Rubbia‐Brandt, Sébastien Tauzin, Catherine Brézault, Céline Delucinge-Vivier, Patrick Descombes , et al. · 2023

Supplementary Tables 1-7 from Gene Expression Profiling Provides Insights into Pathways of Oxaliplatin-Related Sinusoidal Obstruction Syndrome in Humans

Data from Gene Expression Profiling Provides Insights into Pathways of Oxaliplatin-Related Sinusoidal Obstruction Syndrome in Humans Open

Laura Rubbia‐Brandt, Sébastien Tauzin, Catherine Brézault, Céline Delucinge-Vivier, Patrick Descombes , et al. · 2023

Sinusoidal obstruction syndrome (SOS; formerly veno-occlusive disease) is a well-established complication of hematopoietic stem cell transplantation, pyrrolizidine alkaloid intoxication, and widely used chemotherapeutic agents such as oxal…

Supplementary Tables 1-7 from Gene Expression Profiling Provides Insights into Pathways of Oxaliplatin-Related Sinusoidal Obstruction Syndrome in Humans Open

Laura Rubbia‐Brandt, Sébastien Tauzin, Catherine Brézault, Céline Delucinge-Vivier, Patrick Descombes , et al. · 2023

Supplementary Tables 1-7 from Gene Expression Profiling Provides Insights into Pathways of Oxaliplatin-Related Sinusoidal Obstruction Syndrome in Humans

Contents Open

Hanns‐Christian Breit, Ákos Varga‐Szemes, U. Joseph Schoepf, Tilman Emrich, Jon F. Aldinger , et al. · 2023

Biology and Management of High-Grade Chondrosarcoma: An Update on Targets and Treatment Options Open

Camille Tlemsani, Frédérique Larousserie, Sixtine De Percin, Vincent Audard, Djihad Hadjadj , et al. · 2023

This review provides an overview of histopathology, clinical presentation, molecular pathways, and potential new systemic treatments of high-grade chondrosarcomas (CS), including grade 2–3 conventional, dedifferentiated, and mesenchymal CS…

Depressive symptoms after hepatitis C cure and socio-behavioral correlates in aging people living with HIV (ANRS CO13 HEPAVIH) Open

Fabienne Marcellin, Sylvie Brégigeon, Clémence Ramier, Camélia Protopopescu, Camille Gilbert , et al. · 2022

Despite potential improvements in mental health after successful treatment with direct-acting antivirals, many people living with HIV (PLWH) and hepatitis C virus (HCV) - even in older age classes - still face depressive symptoms after HCV…

Outcomes of endoscopic mucosal resection for large superficial non-ampullary duodenal adenomas Open

Maxime Amoyel, Arthur Belle, Marion Dhooge, Einas Abou Ali, Anna Pellat , et al. · 2022

Endoscopic mucosal resection (EMR) is the recommended treatment for superficial non-ampullary duodenal epithelial tumors larger than 6 mm. This endoscopic technique carries a high risk of adverse events. Our aim was to identify the risk fa…

Genetic Diagnosis Guides Treatment of Autoimmune Enteropathy Open

Fabienne Charbit‐Henrion, Manon Haas, Stanislas Chaussade, Christophe Cellier, Nadine Cerf–Bensussan , et al. · 2022

International audience

Discovery and validation of a transcriptional signature identifying homologous recombination-deficient breast, endometrial and ovarian cancers Open

Guillaume Beinse, Pierre‐Alexandre Just, Marie-Aude Le Frère Belda, Pierre Laurent‐Puig, Sébastien Jacques , et al. · 2022

Multicenter Evaluation of the Idylla GeneFusion in Non–Small-Cell Lung Cancer Open

Thomas Depoilly, Simon Garinet, Léon C.L.T. van Kempen, Ed Schuuring, Sergi Clavé , et al. · 2022

HCV cure: an appropriate moment to reduce cannabis use in people living with HIV? (ANRS CO13 HEPAVIH data) Open

Tangui Barré, P. Mercié, C. Lions, Patrick Miailhes, David Zucman , et al. · 2022

Outcomes of Endoscopic Mucosal Resection for Large Superficial Non-Ampullary Duodenal Adenomas Open

Maxime Amoyel, Arthur Belle, Marion Dhooge, Einas Abou Ali, Anna Pellat , et al. · 2022

Background Endoscopic mucosal resection (EMR) is the recommended treatment for superficial non-ampullary duodenal epithelial tumors larger than 6 mm. This endoscopic technique carries a high risk of adverse events. Our aim was to identify …

Highly Specific Droplet-Digital PCR Detection of Universally Methylated Circulating Tumor DNA in Endometrial Carcinoma Open

Guillaume Beinse, Bruno Borghese, Marie Métairie, Pierre‐Alexandre Just, Geoffroy Poulet , et al. · 2022

Background No circulating biomarker is available for endometrial carcinoma (EC). We aimed to identify DNA positions universally hypermethylated in EC, and to develop a digital droplet PCR (ddPCR) assay for detection of hypermethylated circ…

Endoscopic management of non-ampullary duodenal adenomas Open

Romain Coriat, Maximilien Barret, Maxime Amoyel, Arthur Belle, Marion Dhooge , et al. · 2022

Duodenal polyps are found in 0.1 % to 0.8 % of all upper endoscopies. Duodenal adenomas account for 10 % to 20 % of these lesions. They can be sporadic or occur in the setting of a hereditary predisposition syndrome, mainly familial adenom…

Burden of liver disease progression in hospitalized patients with type 2 diabetes mellitus Open

Vincent Mallet, Lucia Parlati, Alessandro Martinino, Juan Pablo Scarano Pereira, Carmen Navas Jiménez , et al. · 2021

1057 Development and validation of a machine-learning-derived RNAseq prognostic signature in endometrial cancer Open

Guillaume Beinse, M. Le Frere Belda, J Pierre-Alexandre, Nahina Bekmezian, Meriem Koual , et al. · 2021

Introduction/Background* Because of inter-tumor heterogeneity of endometrial carcinoma (EC), prognostication remains challenging. We aimed to develop a RNAseq signature to stratify EC patient prognosis beyond molecular subtyping. Methodolo…

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