Benson M. George
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View article: DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells
DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells Open
The extracellular space is a critical environment for discriminating self versus non-self nucleic acids and initiating the appropriate immune responses through signaling cascades to relay information about extracellular nucleic acids. Here…
View article: Development and application of GlycanDIA workflow for glycomic analysis
Development and application of GlycanDIA workflow for glycomic analysis Open
View article: Small RNAs are modified with N-glycans and displayed on the surface of living cells
Small RNAs are modified with N-glycans and displayed on the surface of living cells Open
View article: Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein
Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein Open
Immunotherapies for acute myeloid leukemia (AML) and other cancers are limited by a lack of tumor-specific targets. Here we discover that RNA-binding proteins and glycosylated RNAs (glycoRNAs) form precisely organized nanodomains on cancer…
View article: Mapping the nanoscale organization of the human cell surface proteome reveals new functional associations and surface antigen clusters
Mapping the nanoscale organization of the human cell surface proteome reveals new functional associations and surface antigen clusters Open
The cell surface is a dynamic interface that controls cell-cell communication and signal transduction relevant to organ development, homeostasis and repair, immune reactivity, and pathologies driven by aberrant cell surface phenotypes. The…
View article: Is age just a number? Intensive therapy for core binding factor acute myeloid leukemia in older adults
Is age just a number? Intensive therapy for core binding factor acute myeloid leukemia in older adults Open
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View article: Development and application of GlycanDIA workflow for glycomic analysis
Development and application of GlycanDIA workflow for glycomic analysis Open
Glycans modify protein, lipid, and even RNA molecules to form the regulatory outer coat on cells called the glycocalyx. The changes in glycosylation have been linked to the initiation and progression of many diseases. Thus, while the signi…
View article: The modified RNA base acp3U is an attachment site for N-glycans in glycoRNA
The modified RNA base acp3U is an attachment site for N-glycans in glycoRNA Open
We recently identified glycoRNA—a previously undescribed glycoconjugate—which consists of RNAs modified with secretory N-glycans and presented on the cell surface. While previous work supported a covalent linkage between RNA and glycans, t…
View article: Design of a mucin-selective protease for targeted degradation of cancer-associated mucins
Design of a mucin-selective protease for targeted degradation of cancer-associated mucins Open
Targeted protein degradation is an emerging strategy for the elimination of classically undruggable proteins. Here, to expand the landscape of targetable substrates, we designed degraders that achieve substrate selectivity via recognition …
View article: Rapid and sensitive detection of native glycoRNAs
Rapid and sensitive detection of native glycoRNAs Open
Chemical tools enable precise characterization of many biopolymers, including glycoconjugates. Metabolic chemical reporters enabled the discovery of glycoRNAs, however they have certain limitations due the requirement of having living cell…
View article: Cell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain
Cell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain Open
The diversity of cell types is a challenge for quantifying aging and its reversal. Here we develop ‘aging clocks’ based on single-cell transcriptomics to characterize cell-type-specific aging and rejuvenation. We generated single-cell tran…
View article: Design of a mucin-selective protease for targeted degradation of cancer-associated mucins
Design of a mucin-selective protease for targeted degradation of cancer-associated mucins Open
Targeted protein degradation is an emerging strategy for the elimination of classically undruggable proteins. Here, to expand the landscape of substrates that can be selectively degraded, we designed degraders which are dependent on both p…
View article: Molecular hallmarks of heterochronic parabiosis at single-cell resolution
Molecular hallmarks of heterochronic parabiosis at single-cell resolution Open
View article: Cell type-specific aging clocks to quantify aging and rejuvenation in regenerative regions of the brain
Cell type-specific aging clocks to quantify aging and rejuvenation in regenerative regions of the brain Open
Aging manifests as progressive dysfunction culminating in death. The diversity of cell types is a challenge to the precise quantification of aging and its reversal. Here we develop a suite of ‘aging clocks’ based on single cell transcripto…
View article: Small RNAs are modified with N-glycans and displayed on the surface of living cells
Small RNAs are modified with N-glycans and displayed on the surface of living cells Open
View article: Proteomic analysis of young and old mouse hematopoietic stem cells and their progenitors reveals post-transcriptional regulation in stem cells
Proteomic analysis of young and old mouse hematopoietic stem cells and their progenitors reveals post-transcriptional regulation in stem cells Open
The balance of hematopoietic stem cell (HSC) self-renewal and differentiation is critical for a healthy blood supply; imbalances underlie hematological diseases. The importance of HSCs and their progenitors have led to their extensive char…
View article: Author response: Proteomic analysis of young and old mouse hematopoietic stem cells and their progenitors reveals post-transcriptional regulation in stem cells
Author response: Proteomic analysis of young and old mouse hematopoietic stem cells and their progenitors reveals post-transcriptional regulation in stem cells Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The balance of hematopoietic stem cell (HS…
View article: Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma
Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma Open
(Cell 182, 497–514.e1–e22; July 23, 2020) As a result of human error, the spatial feature plot labeled ITGB1 in Figure 6G was instead a duplicate of the ITGA3 data just below it. Additionally, in Figure S4C, the order of some of the bar la…
View article: Ageing hallmarks exhibit organ-specific temporal signatures
Ageing hallmarks exhibit organ-specific temporal signatures Open
View article: A single-cell transcriptomic atlas characterizes ageing tissues in the mouse
A single-cell transcriptomic atlas characterizes ageing tissues in the mouse Open
View article: Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma
Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma Open
To define the cellular composition and architecture of cutaneous squamous cell carcinoma (cSCC), we combined single-cell RNA sequencing with spatial transcriptomics and multiplexed ion beam imaging from a series of human cSCCs and matched …
View article: Neogenin-1 distinguishes between myeloid-biased and balanced <i>Hoxb5</i> <sup>+</sup> mouse long-term hematopoietic stem cells
Neogenin-1 distinguishes between myeloid-biased and balanced <i>Hoxb5</i> <sup>+</sup> mouse long-term hematopoietic stem cells Open
Hematopoietic stem cells (HSCs) self-renew and generate all blood cells. Recent studies with single cell transplants and lineage tracing suggest that adult HSCs are diverse in their reconstitution and lineage potentials. However, prospecti…
View article: Mass spectrometry analysis of mouse hematopoietic stem cells and their progenitors reveals differential expression within and between proteome and transcriptome throughout adult and aged hematopoiesis
Mass spectrometry analysis of mouse hematopoietic stem cells and their progenitors reveals differential expression within and between proteome and transcriptome throughout adult and aged hematopoiesis Open
Summary Hematopoietic stem cells (HSCs) are responsible for the generation of blood and immune cells throughout life. They have the unique ability to self-renew and generate more HSCs or differentiate into a progenitor cell in response to …
View article: Mammalian Y RNAs are modified at discrete guanosine residues with N-glycans
Mammalian Y RNAs are modified at discrete guanosine residues with N-glycans Open
Glycans modify lipids and proteins to mediate inter- and intramolecular interactions across all domains of life. RNA, another multifaceted biopolymer, is not thought to be a major target of glycosylation. Here, we challenge this view with …
View article: Neutrophil and monocyte kinetics play critical roles in mouse peritoneal adhesion formation
Neutrophil and monocyte kinetics play critical roles in mouse peritoneal adhesion formation Open
Key Points Upon injury, the mesothelium recruits neutrophils to the peritoneal space, which contributes to adhesion formation. Neutrophil recruitment and macrophage-depletion kinetics in adhesions differ from the normal innate response.
View article: Antibody Conditioning Enables MHC-Mismatched Hematopoietic Stem Cell Transplants and Organ Graft Tolerance
Antibody Conditioning Enables MHC-Mismatched Hematopoietic Stem Cell Transplants and Organ Graft Tolerance Open
View article: Neogenin-1 distinguishes between myeloid-biased and balanced<i>Hoxb5</i><sup>+</sup>mouse long-term hematopoietic stem cells
Neogenin-1 distinguishes between myeloid-biased and balanced<i>Hoxb5</i><sup>+</sup>mouse long-term hematopoietic stem cells Open
Hematopoietic stem cells (HSCs) self-renew and generate all blood cells. Recent studies with single-cell transplants (1–3) and lineage tracing (4, 5) suggest that adult HSCs are diverse in their reconstitution and lineage potentials. Howev…
View article: Enabling MHC-mismatched hematopoietic stem cell transplants and organ graft tolerance without chemotherapy or radiation
Enabling MHC-mismatched hematopoietic stem cell transplants and organ graft tolerance without chemotherapy or radiation Open
Summary Hematopoietic stem cell (HSC) transplantation can replace diseased blood systems with a healthy one, thereby treating or curing genetic blood and immune disorders including autoimmune diseases and immunodeficiencies. However, toxic…
View article: Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes Open
Engineering cytokine-receptor pairs Interleukin-2 (IL-2) is an important cytokine that helps T cells destroy tumors and virus-infected cells. IL-2 has great therapeutic promise but is limited by toxic side effects and its capacity to both …
View article: Effects of mechanical loading on cortical defect repair using a novel mechanobiological model of bone healing
Effects of mechanical loading on cortical defect repair using a novel mechanobiological model of bone healing Open