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View article: Proteomics analysis of aqueous and vitreous humor in uveitis: a systematic literature review
Proteomics analysis of aqueous and vitreous humor in uveitis: a systematic literature review Open
Purpose Uveitis is an inflammatory ocular disease with diverse etiologies and pathogeneses. It potentially leads to significant visual impairment and socioeconomic burden. Proteomic analysis can provide insights into protein-driven mechani…
View article: Proteomic Study of Diffuse Large B-Cell Lymphoma Identifying Proteins Associated with R-CHOP Response
Proteomic Study of Diffuse Large B-Cell Lymphoma Identifying Proteins Associated with R-CHOP Response Open
Background/Objectives: Diffuse large B-cell lymphoma (DLBCL) is a molecularly and pathogenically heterogenous disease with varying clinical outcomes, as reflected by the significant number of patients who develop relapse/refractory disease…
View article: Proteomic Profiling of Limited-Stage Follicular Lymphoma Reveals Differentially Expressed Proteins Linked to Disease Progression Post-Radiation Therapy
Proteomic Profiling of Limited-Stage Follicular Lymphoma Reveals Differentially Expressed Proteins Linked to Disease Progression Post-Radiation Therapy Open
Follicular lymphoma (FL) is the most common indolent lymphoma. Despite a generally favorable prognosis and long-term survival for many patients, FL remains incurable, with disease progression occurring in approximately half of limited-stag…
View article: Protein Analysis of the Surface of Orthokeratology Lenses
Protein Analysis of the Surface of Orthokeratology Lenses Open
Introduction: Overnight orthokeratology (OK) lenses control myopia in children, but the underlying mechanism is unclear. We hypothesized that ocular surface proteins might deposit directly on the surface of OK lenses during wear. This coul…
View article: LRP2 is a potential molecular target for nonsyndromic pathological myopia
LRP2 is a potential molecular target for nonsyndromic pathological myopia Open
High myopia (HM) and posterior staphyloma (PS) are major causes of vision loss worldwide. Genetic and environmental factors, especially light exposure, influence myopia. This study shows that low-density lipoprotein-related receptor type 2…
View article: Exhaled breath protein composition in patients hospitalised during the first wave of COVID-19
Exhaled breath protein composition in patients hospitalised during the first wave of COVID-19 Open
Coronavirus 2019 (COVID-19) leads to substantial morbidity and excess mortality all over the world which may be aggravated by the propensity of Severe Acute Respiratory Syndrome Coronavirus 2 to mutate. Mechanisms for development of severe…
View article: Chemokine System Changes Drive Age-Related Macular Degeneration and Influence Treatment Outcomes
Chemokine System Changes Drive Age-Related Macular Degeneration and Influence Treatment Outcomes Open
Patients with nAMD with poor treatment response had dysregulation of the chemokine system. The chemokine system might be a potential target of novel treatment in nAMD. Further studies are needed to clarify the chemokine system's role in nA…
View article: LRP2 is a potential molecular target for pathological myopia
LRP2 is a potential molecular target for pathological myopia Open
High myopia (HM) and posterior staphyloma (PS) are major causes of vision loss worldwide. Genetic and environmental factors, especially light exposure, contribute to myopia. Mutations in low-density lipoprotein-related receptor type 2, LRP…
View article: Plasma Interferon-gamma is Associated with Poor Treatment Response in Neovascular Age-Related Macular Degeneration
Plasma Interferon-gamma is Associated with Poor Treatment Response in Neovascular Age-Related Macular Degeneration Open
Age-related macular degeneration (AMD) is a leading cause of visual impairment and blindness in the elderly. Aging is the most important risk factor for AMD, and the aging immune system seems to be involved in pathogenesis. This study inve…
View article: Differential tumor protein expression at follicular lymphoma diagnosis reveals dysregulation of key molecular pathways associated with histological transformation
Differential tumor protein expression at follicular lymphoma diagnosis reveals dysregulation of key molecular pathways associated with histological transformation Open
Follicular lymphoma (FL) is the most common low-grade lymphoma. Despite its indolent nature, FL carries an inherent risk of histological transformation (HT) to a more aggressive lymphoma. Existing biomarkers are insufficient to predict HT,…
View article: Proteomic Profiling of Lymph Nodes Differentiates Classic Hodgkin Lymphoma With and Without Skeletal Involvement
Proteomic Profiling of Lymph Nodes Differentiates Classic Hodgkin Lymphoma With and Without Skeletal Involvement Open
Classic Hodgkin lymphoma (CHL) is a highly curable disease, even in advanced stages. Controversy remains over whether bone involvement negatively affects overall and progression‐free survival in patients treated with intensive chemotherapy…
View article: Proteomic Profiling Identifies Predictive Signatures for Progression Risk in Patients with Advanced-Stage Follicular Lymphoma
Proteomic Profiling Identifies Predictive Signatures for Progression Risk in Patients with Advanced-Stage Follicular Lymphoma Open
Background: Follicular lymphoma (FL) is characterized by an indolent nature and generally favorable prognosis, yet poses a particular clinical challenge, since disease progression is observed in a notable subset of patients. Currently, it …
View article: Complement C3 is downregulated following ranibizumab intervention in experimental central retinal vein occlusion
Complement C3 is downregulated following ranibizumab intervention in experimental central retinal vein occlusion Open
Purpose Ranibizumab is a frequently used inhibitor of vascular endothelial growth factor (VEGF) in the treatment of macular edema following central retinal vein occlusion (CRVO). Studying proteins that mediate the beneficial effects of ran…
View article: Systemic infection in aged mice causes upregulation of crystallin alpha A in the RPE/choroid
Systemic infection in aged mice causes upregulation of crystallin alpha A in the RPE/choroid Open
Aging changes the responsiveness of our immune defense, and this decline in immune reactivity plays an important role in the increased susceptibility to infections that marks progressing age. Aging is also the most pronounced risk factor f…
View article: Neuroretinal degeneration in a mouse model of systemic chronic immune activation observed by proteomics
Neuroretinal degeneration in a mouse model of systemic chronic immune activation observed by proteomics Open
Blindness or vision loss due to neuroretinal and photoreceptor degeneration affects millions of individuals worldwide. In numerous neurodegenerative diseases, including age-related macular degeneration, dysregulated immune response-mediate…
View article: Chemokine Receptor Profile of T Cells and Progression Rate of Geographic Atrophy Secondary to Age-related Macular Degeneration
Chemokine Receptor Profile of T Cells and Progression Rate of Geographic Atrophy Secondary to Age-related Macular Degeneration Open
Our study finds that chemokine receptors are dysregulated in patients with GA and that CCR6 might be involved in GA progression, making it a potential target for intervention.
View article: Central subfield thickness of diabetic macular edema: Correlation with the aqueous humor proteome
Central subfield thickness of diabetic macular edema: Correlation with the aqueous humor proteome Open
Purpose: Diabetic macular edema (DME) is a sight-threatening complication of diabetes. Consequently, studying the proteome of DME may provide novel insights into underlying molecular mechanisms. Methods: In this study, aqueous humor sample…
View article: A clinical proteomics study of exhaled breath condensate and biomarkers for pulmonary embolism
A clinical proteomics study of exhaled breath condensate and biomarkers for pulmonary embolism Open
Pulmonary embolism (PE) can be a diagnostic challenge. Current diagnostic markers for PE are unspecific and new diagnostic tools are needed. The air we exhale is a possible new source for biomarkers which can be tapped into by analysing th…
View article: Proteome Analysis of Bevacizumab Intervention in Experimental Central Retinal Vein Occlusion
Proteome Analysis of Bevacizumab Intervention in Experimental Central Retinal Vein Occlusion Open
Bevacizumab is a frequently used inhibitor of vascular endothelial growth factor (VEGF) in the management of macular edema in central retinal vein occlusion (CRVO). Studying retinal protein changes in bevacizumab intervention may provide i…
View article: Proteomics uncovers molecular features for relapse risk stratification in patients with diffuse large B-cell lymphoma
Proteomics uncovers molecular features for relapse risk stratification in patients with diffuse large B-cell lymphoma Open
Proteomics uncovers molecular features for
View article: Tear film proteome changes following Tobradex<sup>®</sup> therapy in anterior blepharitis
Tear film proteome changes following Tobradex<sup>®</sup> therapy in anterior blepharitis Open
Purpose The management of blepharitis continues to challenge clinicians due to the poorly understood aetiology of the condition. We recently identified the family of intracellular plakin proteins as essential driving forces underlying ante…
View article: Meibomian Gland Dysfunction Is Associated with Low Levels of Immunoglobulin Chains and Cystatin-SN
Meibomian Gland Dysfunction Is Associated with Low Levels of Immunoglobulin Chains and Cystatin-SN Open
Meibomian gland dysfunction (MGD) is a highly prevalent condition and the most common cause of evaporative dry eye disease. Studying the proteome of MGD can result in important advances in the management of the condition. Here, we collecte…
View article: Proteomics identifies apoptotic markers as predictors of histological transformation in patients with follicular lymphoma
Proteomics identifies apoptotic markers as predictors of histological transformation in patients with follicular lymphoma Open
Follicular lymphoma (FL) is an indolent lymphoma with a generally favorable prognosis. However, histological transformation (HT) to a more aggressive disease leads to markedly inferior outcomes. This study aims to identify biological diffe…
View article: Systemic virus infection results in CD8 T cell recruitment to the retina in the absence of local virus infection
Systemic virus infection results in CD8 T cell recruitment to the retina in the absence of local virus infection Open
During recent years, evidence has emerged that immune privileged sites such as the CNS and the retina may be more integrated in the systemic response to infection than was previously believed. In line with this, it was recently shown that …
View article: Diurnal proteome profile of the mouse cerebral cortex: Conditional deletion of the <i>Bmal1</i> circadian clock gene elevates astrocyte protein levels and cell abundance in the neocortex and hippocampus
Diurnal proteome profile of the mouse cerebral cortex: Conditional deletion of the <i>Bmal1</i> circadian clock gene elevates astrocyte protein levels and cell abundance in the neocortex and hippocampus Open
Circadian oscillators, defined by cellular 24 h clock gene rhythms, are found throughout the brain. Cerebral cortex‐specific conditional knockout of the clock gene Bmal1 ( Bmal1 CKO) leads to depressive‐like behavior, but the molecular lin…
View article: Proteomic profiling identifies apoptotic deregulation predictive of histological transformation in follicular lymphoma
Proteomic profiling identifies apoptotic deregulation predictive of histological transformation in follicular lymphoma Open
Introduction: Follicular lymphoma (FL) is a lymphoid neoplasia arising from germinal center B cells, characterized by the t(14;18) translocation and subsequent upregulation of anti-apoptotic B-cell lymphoma 2 (BCL2) proteins. While charact…
View article: Proteomic profiling differentiates classic Hodgkin lymphoma with and without skeletal involvement at the time of diagnosis
Proteomic profiling differentiates classic Hodgkin lymphoma with and without skeletal involvement at the time of diagnosis Open
Introduction: Classic Hodgkin lymphoma (cHL) is a highly curable disease, even in advanced stages. It is controversial whether bone involvement has a negative effect on overall- and progression-free survival in patients treated with intens…
View article: Large-Scale Protein Analysis of Experimental Retinal Artery Occlusion
Large-Scale Protein Analysis of Experimental Retinal Artery Occlusion Open
Retinal artery occlusion (RAO) is a devastating condition with no effective treatment. The management of RAO could potentially be improved through an in-depth understanding of the molecular alterations in the condition. This study combined…