Benyan Luo
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View article: Efficacy and safety of adjunctive tirofiban administration in anterior large vessel occlusion due to large artery atherosclerosis: an individual patient data pooled analysis of two randomized clinical trials
Efficacy and safety of adjunctive tirofiban administration in anterior large vessel occlusion due to large artery atherosclerosis: an individual patient data pooled analysis of two randomized clinical trials Open
Background: The role of different adjunctive tirofiban administration routes during endovascular thrombectomy (EVT) for acute ischemic stroke (AIS) due to large artery atherosclerosis (LAA) remains controversial. We evaluated the efficacy …
View article: Altered oral microbiomes in patients with prolonged disorders of consciousness
Altered oral microbiomes in patients with prolonged disorders of consciousness Open
These findings highlight oral microbiome alterations in pDoC and their potential relevance to disease progression, emphasizing the importance of microbiome-informed clinical strategies.
View article: Smoking Cessation, Weight Change, and Risk of Dementia: A Prospective Cohort Study
Smoking Cessation, Weight Change, and Risk of Dementia: A Prospective Cohort Study Open
Objectives To assess the associations of smoking cessation and post-cessation weight gain with the risk of dementia and cognitive trajectories. Design Prospective cohort study. Setting The U.S. Health and Retirement Study (1995-2020). Part…
View article: Genetically predicted white matter microstructure mediates the relationship between risk factors and lacunar stroke
Genetically predicted white matter microstructure mediates the relationship between risk factors and lacunar stroke Open
Background and purpose Lacunar stroke is a complex, multifactorial disease with significant genetic underpinnings. However, the mechanisms through which genetic predispositions and risk factors contribute to its pathogenesis remain poorly …
View article: Abnormalities of regional brain activity in patients with asymptomatic internal carotid artery occlusion: a resting-state fMRI study
Abnormalities of regional brain activity in patients with asymptomatic internal carotid artery occlusion: a resting-state fMRI study Open
Our findings revealed abnormal local spontaneous brain activity within brain regions associated with cognitive functions in patients with unilateral aICAO. Notably, some of these abnormalities correlated with their cognitive impairments. T…
View article: Impact of Endovascular Revascularization on Functional Connectivity and Cognition in Symptomatic Chronic Internal Carotid Artery Occlusion Patients: A Preliminary Exploratory Study
Impact of Endovascular Revascularization on Functional Connectivity and Cognition in Symptomatic Chronic Internal Carotid Artery Occlusion Patients: A Preliminary Exploratory Study Open
Background: Symptomatic chronic internal carotid artery occlusion (CICAO) may lead to stroke and cognitive decline. Although endovascular recanalization has been proven to reduce the risk of future strokes, the effect on cognition remains …
View article: Personalized Sleep Staging Leveraging Source-free Unsupervised Domain Adaptation
Personalized Sleep Staging Leveraging Source-free Unsupervised Domain Adaptation Open
Sleep staging is important for monitoring sleep quality and diagnosing sleep-related disorders. Recently, numerous deep learning-based models have been proposed for automatic sleep staging using polysomnography recordings. Most of them are…
View article: Personalized Sleep Staging Leveraging Source-free Unsupervised Domain Adaptation
Personalized Sleep Staging Leveraging Source-free Unsupervised Domain Adaptation Open
Sleep staging is crucial for assessing sleep quality and diagnosing related disorders. Recent deep learning models for automatic sleep staging using polysomnography often suffer from poor generalization to new subjects because they are tra…
View article: Inhibition of Smad4 improves the cognitive function of APP/PS1 mice by targeting the level of c1qa
Inhibition of Smad4 improves the cognitive function of APP/PS1 mice by targeting the level of c1qa Open
Background Synaptic plasticity impairment plays a critical role in the pathogenesis of Alzheimer’s disease (AD), Smad4, a central intracellular signal transmission mediator of transmission of transforming growth factor‐β (TGF‐β) signaling,…
View article: Recombinant <i>Saccharomyces cerevisiae</i> EBY100/pYD1-FaeG: a candidate for an oral subunit vaccine against F4+ ETEC infection
Recombinant <i>Saccharomyces cerevisiae</i> EBY100/pYD1-FaeG: a candidate for an oral subunit vaccine against F4+ ETEC infection Open
Diarrheal diseases attributable to multidrug-resistant F4+ enterotoxigenic Escherichia coli (ETEC) are escalating in severity, posing significant risks to the health and safety of both humans and animals. This study used Saccharomyces cere…
View article: Sirt6 Mono‐ADP‐Ribosylates YY1 to Promote Dystrophin Expression for Neuromuscular Transmission
Sirt6 Mono‐ADP‐Ribosylates YY1 to Promote Dystrophin Expression for Neuromuscular Transmission Open
The degeneration of the neuromuscular junction (NMJ) and the decline in motor function are common features of aging, but the underlying mechanisms have remained largely unclear. This study reveals that Sirt6 is reduced in aged mouse muscle…
View article: CX3CR1+/UCHL1+ microglial extracellular vesicles in blood: a potential biomarker for multiple sclerosis
CX3CR1+/UCHL1+ microglial extracellular vesicles in blood: a potential biomarker for multiple sclerosis Open
In neuroinflammation, distinguishing microglia from macrophages and identifying microglial-specific biomarkers in peripheral blood pose significant challenges. This study comprehensively profiled the extracellular vesicles (EVs) of microgl…
View article: Assessing consciousness in acute coma using name-evoked responses
Assessing consciousness in acute coma using name-evoked responses Open
Detecting consciousness in clinically unresponsive patients remains a significant challenge. Existing studies demonstrate that electroencephalography (EEG) can detect brain responses in behaviorally unresponsive patients, indicating potent…
View article: Local protein synthesis at neuromuscular synapses is required for motor functions
Local protein synthesis at neuromuscular synapses is required for motor functions Open
Motor neurons are highly polarized, and their axons extend over great distances to form connections with myofibers via neuromuscular junctions (NMJs). Local translation at the NMJs in vivo has not been identified. Here, we utilized motor n…
View article: Alterations in metabolome and lipidome in patients with in‐stent restenosis
Alterations in metabolome and lipidome in patients with in‐stent restenosis Open
Context In‐stent restenosis (ISR) can lead to blood flow obstruction, insufficient blood supply to the brain, and may even result in serious complications such as stroke. Endothelial cell hyperproliferation and thrombosis are the primary e…
View article: Diagnostic value of isolated plasma biomarkers and its combination in neurodegenerative dementias: A multicenter cohort study
Diagnostic value of isolated plasma biomarkers and its combination in neurodegenerative dementias: A multicenter cohort study Open
Our results confirmed the diagnostic performance of individual plasma biomarkers Aβ42/Aβ40, p-tau181, NfL, and GFAP in Chinese dementia patients and noted that a combination of these biomarkers may be more accurate in identifying FTD/PSP p…
View article: The subcommissural organ regulates brain development via secreted peptides
The subcommissural organ regulates brain development via secreted peptides Open
The subcommissural organ (SCO) is a gland located at the entrance of the aqueduct of Sylvius in the brain. It exists in species as distantly related as amphioxus and humans, but its function is largely unknown. To explore its function, we …
View article: How well do neural signatures of resting‐state <scp>EEG</scp> detect consciousness? A large‐scale clinical study
How well do neural signatures of resting‐state <span>EEG</span> detect consciousness? A large‐scale clinical study Open
The assessment of consciousness states, especially distinguishing minimally conscious states (MCS) from unresponsive wakefulness states (UWS), constitutes a pivotal role in clinical therapies. Despite that numerous neural signatures of con…
View article: Endovascular recanalization in vertebral artery stump syndrome: a single-center experience
Endovascular recanalization in vertebral artery stump syndrome: a single-center experience Open
Objective To evaluate the feasibility, success rate, and safety of endovascular revascularization of patients with vertebral artery stump syndrome (VASS). Methods This single-center retrospective study analyzed clinical and imaging data fr…
View article: DiffMDD: A Diffusion-Based Deep Learning Framework for MDD Diagnosis Using EEG
DiffMDD: A Diffusion-Based Deep Learning Framework for MDD Diagnosis Using EEG Open
Major Depression Disorder (MDD) is a common yet destructive mental disorder that affects millions of people worldwide. Making early and accurate diagnosis of it is very meaningful. Recently, EEG, a non-invasive technique of recording spont…
View article: Navigating the Molecular Maze of Alzheimer’s Disease: Developing A Human Hippocampal Atlas to Bridge Discovery and Clinical Practice
Navigating the Molecular Maze of Alzheimer’s Disease: Developing A Human Hippocampal Atlas to Bridge Discovery and Clinical Practice Open
Alzheimer’s disease (AD), the primary cause of dementia worldwide, persists as an enigma, with the specific molecular and cellular mechanisms driving cognitive decline still eluding understanding. To aid in unraveling this enigma, we gener…
View article: Digitized Biomarkers Utilizing Human‐Computer Interaction Sensing Technology for Early Auxiliary Diagnosis of Alzheimer’s Disease
Digitized Biomarkers Utilizing Human‐Computer Interaction Sensing Technology for Early Auxiliary Diagnosis of Alzheimer’s Disease Open
Background Alzheimer’s disease (AD) is a progressive and debilitating neurological disorder that impacts millions of individuals globally. Prompt and accurate detection and diagnosis of Alzheimer’s disease are pivotal for providing effecti…
View article: Identification of Candidate Biomarkers of Alzheimer’s Disease via Multiplex Cerebrospinal Fluid and Serum Proteomics
Identification of Candidate Biomarkers of Alzheimer’s Disease via Multiplex Cerebrospinal Fluid and Serum Proteomics Open
Alzheimer’s disease (AD) is the most prevalent form of dementia among elderly people worldwide. Cerebrospinal fluid (CSF) is the optimal fluid source for AD biomarkers, while serum biomarkers are much more achievable. To search for novel d…
View article: Effect of topographic comparison of electroencephalographic microstates on the diagnosis and prognosis prediction of patients with prolonged disorders of consciousness
Effect of topographic comparison of electroencephalographic microstates on the diagnosis and prognosis prediction of patients with prolonged disorders of consciousness Open
Aims The electroencephalography (EEG) microstates are indicative of fundamental information processing mechanisms, which are severely damaged in patients with prolonged disorders of consciousness (pDoC). We aimed to improve the topographic…
View article: Acoustic‐electric trigeminal‐nerve stimulation enhances functional connectivity in patients with disorders of consciousness
Acoustic‐electric trigeminal‐nerve stimulation enhances functional connectivity in patients with disorders of consciousness Open
Aim Disruption of functional brain connectivity is thought to underlie disorders of consciousness (DOC) and recovery of impaired connectivity is suggested as an indicator of consciousness restoration. We recently found that rhythmic acoust…