Beom Jin Lim
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View article: #511 A case of MPO-ANCA positive dense deposit disease (DDD) with normal C3 levels presenting with end-stage renal disease (ESRD) at admission
#511 A case of MPO-ANCA positive dense deposit disease (DDD) with normal C3 levels presenting with end-stage renal disease (ESRD) at admission Open
Background and Aims Dense Deposit Disease (DDD) is a type of C3 glomerulopathy, a rare form of glomerulonephritis caused by abnormal regulation of the alternative complement pathway. It is primarily diagnosed in children aged between 5 and…
View article: Lysyl oxidase-like 2 inhibition ameliorated podocyte fibrosis by inhibiting transforming growth factor-beta signaling under high-glucose conditions
Lysyl oxidase-like 2 inhibition ameliorated podocyte fibrosis by inhibiting transforming growth factor-beta signaling under high-glucose conditions Open
LOXL2 is upregulated in diabetic podocytes and contributes to hyperglycemia-induced fibrosis by activating the TGF-β/Smad signaling pathway. These findings suggest that LOXL2 may serve as a potential therapeutic target for preventing or at…
View article: A New Staining Method Using Methionyl-tRNA Synthetase 1 Antibody for Endoscopic Ultrasound-Guided Fine-Needle Aspiration Cytology of Pancreatic Cancer
A New Staining Method Using Methionyl-tRNA Synthetase 1 Antibody for Endoscopic Ultrasound-Guided Fine-Needle Aspiration Cytology of Pancreatic Cancer Open
Background/Objectives: Accurate determination of malignancy in pancreatic masses through endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is crucial for appropriate clinical management and prognostic assessment. However, the d…
View article: Deep learning-based quantitative analysis of glomerular morphology in IgA nephropathy whole slide images and its prognostic implications
Deep learning-based quantitative analysis of glomerular morphology in IgA nephropathy whole slide images and its prognostic implications Open
Kidney pathology of immunoglobulin A nephropathy (IgAN), which is the key finding of both diagnosis and risk stratification, involves labor-intensive manual interpretation as well as unavoidable interpreter-dependent variabilities. We prop…
View article: Loss of p300 in proximal tubular cells reduces renal fibrosis and endothelial-mesenchymal transition
Loss of p300 in proximal tubular cells reduces renal fibrosis and endothelial-mesenchymal transition Open
Chronic kidney disease (CKD) has a high prevalence worldwide and is typically accompanied by severe fibrosis. However, the exact pathogenesis of renal fibrosis and effective treatments have yet to be identified. In this study, we found tha…
View article: Interobserver agreement analysis among renal pathologists in classification of lupus nephritis using a digital pathology image dataset: after a third evaluation
Interobserver agreement analysis among renal pathologists in classification of lupus nephritis using a digital pathology image dataset: after a third evaluation Open
This study conducted an interobserver agreement analysis of Korean pathologists for lupus nephritis, with the goal of increasing agreement through education. Although the education increased overall agreement, items like "mesangial hyperce…
View article: Pathological diagnosis of Alport syndrome
Pathological diagnosis of Alport syndrome Open
Alport syndrome (AS) is a hereditary nephritis characterized by structural abnormalities in the glomerular basement membrane resulting from pathogenic variants in the COL4A3, COL4A4, and COL4A5 genes. Conventional pathological evaluations …
View article: Heavy-chain deposition disease associated with multiple myeloma: a case report
Heavy-chain deposition disease associated with multiple myeloma: a case report Open
Heavy-chain deposition disease (HCDD) is a rare disorder characterized by the deposition of monoclonal immunoglobulin. Due to the disease's rarity and diagnostic challenges, its prognosis is generally poor. Herein, we report a case of succ…
View article: Glomerulonephritis following COVID-19 infection or vaccination: a multicenter study in South Korea
Glomerulonephritis following COVID-19 infection or vaccination: a multicenter study in South Korea Open
Background: Despite the widespread impact of the severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019, COVID-19) and vaccination in South Korea, our understanding of kidney diseases following these events remains limit…
View article: Repositioning of ezetimibe for the treatment of idiopathic pulmonary fibrosis
Repositioning of ezetimibe for the treatment of idiopathic pulmonary fibrosis Open
Background We previously identified ezetimibe, an inhibitor of Niemann–Pick C1-like intracellular cholesterol transporter 1 and European Medicines Agency-approved lipid-lowering agent, as a potent autophagy activator. However, its efficacy…
View article: Clinical significance of late onset antibody-mediated rejection without donor-specific anti-human leukocyte antigen antibodies in kidney transplantation
Clinical significance of late onset antibody-mediated rejection without donor-specific anti-human leukocyte antigen antibodies in kidney transplantation Open
Younsoo Seo, Minyu Kang, Hwahee Koh, Seung Hyuk Yim, Mun Chae Choi, Juhan Lee, Beom Jin Lim, Beom Seok Kim, Myoung Soo Kim, Kyu Ha Huh. Korean J Transplant 2023;37:211. https://doi.org/10.4285/ATW2023.F-8022
View article: Machine learning-based 2-year risk prediction tool in immunoglobulin A nephropathy
Machine learning-based 2-year risk prediction tool in immunoglobulin A nephropathy Open
Background: This study aimed to develop a machine learning-based 2-year risk prediction model for early identification of patients with rapid progressive immunoglobulin A nephropathy (IgAN). We also assessed the model’s performance to pred…
View article: Renal histopathological predictors of end-stage kidney disease in ANCA-associated vasculitis with glomerulonephritis: a single-centre study in Korea
Renal histopathological predictors of end-stage kidney disease in ANCA-associated vasculitis with glomerulonephritis: a single-centre study in Korea Open
This study investigated whether histopathological classification and histologic lesion scores could significantly and independently predict the progression to end-stage kidney disease (ESKD) in Korean patients with antineutrophil cytoplasm…
View article: Treatment of malignant perivascular epithelioid cell tumor (PEComa) on the knee with an anterolateral thigh free flap: A case report
Treatment of malignant perivascular epithelioid cell tumor (PEComa) on the knee with an anterolateral thigh free flap: A case report Open
Rationale: The World Health Organization defines a perivascular epithelioid cell tumor (PEComa) as a mesenchymal neoplasia composed of perivascular epithelioid cells with characteristic morphological and immunohistochemical features. Altho…
View article: Macrophage transcription factor TonEBP promotes systemic lupus erythematosus and kidney injury via damage-induced signaling pathways
Macrophage transcription factor TonEBP promotes systemic lupus erythematosus and kidney injury via damage-induced signaling pathways Open
Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by autoreactive B cells and dysregulation of many other types of immune cells including myeloid cells. Lupus nephritis (LN) is a common target organ manifestations …
View article: Histologic evaluation of activity and chronicity of lupus nephritis and its clinical significance
Histologic evaluation of activity and chronicity of lupus nephritis and its clinical significance Open
The National Institutes of Health (NIH) lupus nephritis activity and chronicity indices, which comprise six activity scores and four chronicity scores, have a long development history. The 2018 revised International Society of Nephrology/R…
View article: Renal histopathological indices for predicting the progression to end-stage kidney disease in patients with antineutrophil cytoplasmic antibody-associated vasculitis and glomerulonephritis: a single-centre study in Korea
Renal histopathological indices for predicting the progression to end-stage kidney disease in patients with antineutrophil cytoplasmic antibody-associated vasculitis and glomerulonephritis: a single-centre study in Korea Open
Objective This study investigated whether histopathological classification and histologic lesion scores could significantly and independently predict the progression to end-stage kidney disease (ESKD) in Korean patients with antineutrophil…
View article: Clinicopathologic characteristics of neuroendocrine tumors with assessment by digital image analysis for Ki-67 index with a focus on the gastroenteropancreatic tract: a single-center study.
Clinicopathologic characteristics of neuroendocrine tumors with assessment by digital image analysis for Ki-67 index with a focus on the gastroenteropancreatic tract: a single-center study. Open
Eyeball estimation revealed non-inferior results compared with digital image analysis. Further research is needed to evaluate the possibility of using digital image analysis as an alternative analysis method.
View article: Successful treatment of renal malakoplakia via the reduction of immunosuppression and antimicrobial therapy after kidney transplantation: a case report
Successful treatment of renal malakoplakia via the reduction of immunosuppression and antimicrobial therapy after kidney transplantation: a case report Open
Malakoplakia is a rare, granulomatous disease that usually affects immunocompromised individuals and is generally associated with poor graft and patient survival. We present a case of renal malakoplakia after kidney transplantation (KT). A…
View article: Clinical significance of late onset antibody-mediated rejection without donor-specific anti-human leukocyte antigen antibodies in kidney transplantation
Clinical significance of late onset antibody-mediated rejection without donor-specific anti-human leukocyte antigen antibodies in kidney transplantation Open
Background: Late onset antibody-mediated rejection (AMR) is a leading cause of allograft failure after kidney transplantation.Although the presence of donor-specific antibodies (DSA) is no longer required for AMR diagnosis according to Ban…
View article: Medullary histology may help to predict Banff scores in allograft kidneys
Medullary histology may help to predict Banff scores in allograft kidneys Open
Background: Most of the current Banff classification parameters for renal allograft are obtained from the cortex.For example, the peritubular capillaritis score is obtained only in cortical capillaries, but their medullary counterpart (vas…
View article: Successful treatment of renal malakoplakia with reduction of immunosuppression and antimicrobial therapy after kidney transplantation: case report
Successful treatment of renal malakoplakia with reduction of immunosuppression and antimicrobial therapy after kidney transplantation: case report Open
Malakoplakia is a rare granulomatous disease that usually affects immunocompromised individuals.Genitourinary tract is the most frequent site of infection, manifesting as recurrent urinary tract infection with impaired renal function.Cases…
View article: Inhibition of lysyl oxidase‑like 2 ameliorates folic acid‑induced renal tubulointerstitial fibrosis
Inhibition of lysyl oxidase‑like 2 ameliorates folic acid‑induced renal tubulointerstitial fibrosis Open
Tubulointerstitial fibrosis is characterized by accumulation of the extracellular matrix in the interstitium. Lysyl oxidase-like 2 (LOXL2), a member of the lysyl oxidase family, is known for promoting cancer metastasis, invasion and stroma…
View article: Dexmedetomidine attenuates subarachnoid hemorrhage-induced acute lung injury through regulating autophagy and TLR/NF-kappaB signaling pathway
Dexmedetomidine attenuates subarachnoid hemorrhage-induced acute lung injury through regulating autophagy and TLR/NF-kappaB signaling pathway Open
Low-dose DEX treatment after SAH may protect against ALI by disrupting pathological brain-lung crosstalk and alleviating autophagy flux and TLR-dependent inflammatory pathways.
View article: Assessment of Device Neoendothelialization With Cardiac Computed Tomography Angiography After Transcatheter Closure of Atrial Septal Defect
Assessment of Device Neoendothelialization With Cardiac Computed Tomography Angiography After Transcatheter Closure of Atrial Septal Defect Open
Background: Although the transcatheter closure of atrial septal defect was established as the treatment of choice several decades ago, the process of device neoendothelialization (NE) in humans is not well understood. We aimed to measure t…