Explanipedia

HLA-E and NKG2A Mediate Resistance to BCG Immunotherapy in Non-Muscle-Invasive Bladder Cancer Open

Daniel Ranti, Haocheng Yu, Alex Wang, C P Bieber, Trine Strandgaard , et al. · 2024

SUMMARY Bacillus Calmette-Guérin (BCG) is the first-line therapy for high-grade non-muscle-invasive bladder cancer (NMIBC), yet many patients experience recurrence due to immune evasion. We identify HLA-E and NKG2A as mediators of adaptive…

CARCINOMEEPIDERMOIDEDU SCALP:APROPOSDUNCASMULTI-COMPLIQUE.SQUAMOUSCELLCARCINOMAOFSCALP: ACASEREPORTOF APATIENT WITH MULTIPLE COMPLICATIONS Open

Mukhtar Hussain Sahir, a Marzak, Bérengère Salomé, c Benlaguide, Abdoulaye Sylla , et al. · 2023

Squamous cell carcinoma of the scalp is frequent in our field of practice. Nevertheless, we report the case of a patient who had consulted at a locally advanced stage of the tumour. The patient was being monitored in our department and had…

PEDIATRIC BURN MECHANISMS AND ITS PREVENTIONS: AN EPIDEMIOLOGICAL ANALYSISOF CHILDREN ADMITTED TO THE UHC MOHAMMED VI PLASTIC SURGERY DEPARTMENT IN MARRAKECH, MOROCCO Open

Mukhtar Hussain Sahir, Abdelaziz Marzak, Bérengère Salomé, c Benlaguide, A. Sylla , et al. · 2023

This study aims to describe the causes, mechanisms and characteristics of children burn injuries. It is a retrospective study that analyses the epidemiological particularities that are leading causes to burn injuries of a 100 cases of pedi…

Supplementary figures and legends from Immunosuppressive Mediators Impair Proinflammatory Innate Lymphoid Cell Function in Human Malignant Melanoma Open

Giuseppe Ercolano, Andrea Garcia-Garijo, Bérengère Salomé, Alejandra Gomez‐Cadena, Giulia Vanoni , et al. · 2023

Supplementary figures and legends

Data from Immunosuppressive Mediators Impair Proinflammatory Innate Lymphoid Cell Function in Human Malignant Melanoma Open

Giuseppe Ercolano, Andrea Garcia-Garijo, Bérengère Salomé, Alejandra Gomez‐Cadena, Giulia Vanoni , et al. · 2023

Innate lymphoid cells (ILC) are a family of immune cells that are emerging as potent orchestrators of immune responses. In cancer, ILCs display both pro- and antitumorigenic functions depending on the nature of the tumor and the involved I…

Supplementary figures and legends from Immunosuppressive Mediators Impair Proinflammatory Innate Lymphoid Cell Function in Human Malignant Melanoma Open

Giuseppe Ercolano, Andrea García-Garijo, Bérengère Salomé, Alejandra Gomez‐Cadena, Giulia Vanoni , et al. · 2023

Supplementary figures and legends

Data from Immunosuppressive Mediators Impair Proinflammatory Innate Lymphoid Cell Function in Human Malignant Melanoma Open

Giuseppe Ercolano, Andrea García-Garijo, Bérengère Salomé, Alejandra Gomez‐Cadena, Giulia Vanoni , et al. · 2023

Innate lymphoid cells (ILC) are a family of immune cells that are emerging as potent orchestrators of immune responses. In cancer, ILCs display both pro- and antitumorigenic functions depending on the nature of the tumor and the involved I…

NKG2A and HLA-E define an alternative immune checkpoint axis in bladder cancer Open

Bérengère Salomé, John P. Sfakianos, Daniel Ranti, Jorge Daza, Christine Bieber , et al. · 2022

Elevated HLA-E and NKG2A as a Consequence of Chronic Immune Activation Defines Resistance to <i>M. bovis</i> BCG Immunotherapy in Non-Muscle-Invasive Bladder Cancer Open

Daniel Ranti, Alex Wang, Jorge Daza, C P Bieber, Bérengère Salomé , et al. · 2022

Mycobacterium bovis Bacillus Calmette-Guerin (BCG), the first-line treatment for non-muscle invasive bladder cancer (NMIBC), promotes the production of inflammatory cytokines, particularly interferon (IFN)-γ. Prolonged inflammation and IFN…

NKG2A and HLA-E define a novel alternative immune checkpoint axis in bladder cancer Open

Bérengère Salomé, John P. Sfakianos, Jorge Daza, Andrew Charap, Christian Hammer , et al. · 2022

Summary PD-1/PD-L1-blockade immunotherapies have limited efficacy in the treatment of muscle-invasive bladder cancer (MIBC) and metastatic urothelial carcinoma. Here, we show that KLRC1 (NKG2A) expression associates with improved survival …

621 NKG2A and HLA-E define a novel mechanism of resistance to immunotherapy with M. bovis BCG in non-muscle-invasive bladder cancer patients Open

Amir Horowitz, Jorge Daza, Yinchong Wang, Daniel Ranti, Bérengère Salomé , et al. · 2021

Background 75% of diagnosed bladder tumors are non-muscle-invasive (NMIBC)[1, 2]. Most require intravesical instillation of M.bovis Bacillus Calmette-Guérin (BCG). Recurrence after immunotherapy occurs in ~50% patients. Development of trea…

314 NKG2A and HLA-E define a novel alternative immune checkpoint axis in bladder cancer Open

Bérengère Salomé, John P. Sfakianos, Andrew Charap, Adam M. Farkas, Daniel Geanon , et al. · 2021

Background Bladder cancer is characterized by a poor prognosis, with muscle-invasive cases harboring a 34–76% 10-year recurrence-free survival rate. 1 Neoadjuvant PD-1/PD-L1 blockade strategies have recently been approved by the US Food an…

PD42-03 HIGH LEVELS OF BASELINE IGG1, IGG3, AND IFN-G MAY BE ASSOCIATED WITH RESISTANCE TO BCG THERAPY FOR TREATMENT OF NMIBC Open

Jorge Daza, Yuanshuo Wang, Andrew Charap, Bérengère Salomé, Rachel Brody , et al. · 2021

You have accessJournal of UrologyBladder Cancer: Basic Research & Pathophysiology II (PD42)1 Sep 2021PD42-03 HIGH LEVELS OF BASELINE IGG1, IGG3, AND IFN-G MAY BE ASSOCIATED WITH RESISTANCE TO BCG THERAPY FOR TREATMENT OF NMIBC Jorge Daza, …

Modulation of immune crosstalk in COVID-19 Open

Bérengère Salomé, Zafar Mahmood · 2020

Immunology of COVID-19: Current State of the Science Open

Nicolas Vabret, Graham J. Britton, Conor Gruber, Samarth Hegde, Joel Kim , et al. · 2020

Dysregulation of lung myeloid cells in COVID-19 Open

Bérengère Salomé, Assaf Magen · 2020

MP80-01 RADIOPROTEOMIC ANALYSIS AS A POTENTIAL PREDICTOR OF RENAL TUMOR HISTOPATHOLOGY Open

Jorge Daza, Bérengère Salomé, Octavia Bane, Sara Lewis, John P. Sfakianos , et al. · 2020

You have accessJournal of UrologyKidney Cancer: Epidemiology & Evaluation/Staging/Surveillance III (MP80)1 Apr 2020MP80-01 RADIOPROTEOMIC ANALYSIS AS A POTENTIAL PREDICTOR OF RENAL TUMOR HISTOPATHOLOGY Jorge Daza*, Berengere Salome, Octavi…

MP17-08 HLA-E EXPRESSION PREDICTS PROGRESSION, THERAPEUTIC RESPONSE AND OVERALL SURVIVAL IN PATIENTS WITH BLADDER CANCER Open

Jorge Daza, Dan Fu Ruan, Bérengère Salomé, Andrew Charap, Peter Wiklund , et al. · 2020

You have accessJournal of UrologyBladder Cancer: Basic Research & Pathophysiology II (MP17)1 Apr 2020MP17-08 HLA-E EXPRESSION PREDICTS PROGRESSION, THERAPEUTIC RESPONSE AND OVERALL SURVIVAL IN PATIENTS WITH BLADDER CANCER Jorge Daza*, Dan …

Distinct and shared gene expression for human innate versus adaptive helper lymphoid cells Open

Giuseppe Ercolano, Tania Wyss, Bérengère Salomé, Pedro Romero, Sara Trabanelli , et al. · 2020

Innate lymphoid cells (ILCs) are the latest identified innate immune cell family. Given their similarity in transcription factor expression and cytokine secretion profiles, ILCs have been considered as the innate phenocopy of CD4 Th cells.…

CD56 as a marker of an ILC1-like population with NK cell properties that is functionally impaired in AML Open

Bérengère Salomé, Alejandra Gomez‐Cadena, Romain Loyon, Madeleine Suffiotti, Valentina Salvestrini , et al. · 2019

Key Points Human ILC1-like cells kill tumors in a KIR-independent manner. The cytotoxicity of human ILC1-like cells is impaired in AML at diagnosis but is restored in remission.

Peripheral Innate Lymphoid Cells Are Increased in First Line Metastatic Colorectal Carcinoma Patients: A Negative Correlation With Th1 Immune Responses Open

Romain Loyon, Marine Jary, Bérengère Salomé, Alejandra Gomez‐Cadena, Jeanne Galaine , et al. · 2019

Several distinct innate lymphoid cell (ILC) populations have been recently identified and shown to play a critical role in the immediate immune defense. In the context of tumors, there is evidence to support a dual role for ILCs with pro- …

Innate lymphoid cells in antitumor immunity Open

Bérengère Salomé, Camilla Jandus · 2017

Innate lymphoid cells (ILCs) are the most recently characterized subset of innate lymphocytes. Based on their specific transcriptional regulation, cytokine secretion pattern and effector functions ILCs mirror the different CD4 T helper cel…

Human innate lymphoid cells (ILCs): Toward a uniform immune‐phenotyping Open

Sara Trabanelli, Alejandra Gomez‐Cadena, Bérengère Salomé, Katarzyna Michaud, Domenico Mavilio , et al. · 2017

Helper innate lymphoid cells (ILCs), the most recently identified population of the ILC family, play a fundamental role in the restoration of tissue integrity, in the protection against infiltrating pathogens as well as in tumor immune‐sur…

Dysregulated Innate Lymphocytes in Patients With Primary Antibody Deficiency Treated With Intravenous Immunoglobulin Open

Selena Viganó, Sara Trabanelli, F Indulsi, Bérengère Salomé, Alexandre Harari , et al. · 2017

Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis Open

Sara Trabanelli, Mathieu F. Chevalier, Amaia Martínez-Usatorre, Alejandra Gomez‐Cadena, Bérengère Salomé , et al. · 2017

ILC2-modulated T cell–to-MDSC balance is associated with bladder cancer recurrence Open

Mathieu F. Chevalier, Sara Trabanelli, Julien Racle, Bérengère Salomé, Valérie Cesson , et al. · 2017

Non-muscle-invasive bladder cancer (NMIBC) is a highly recurrent tumor despite intravesical immunotherapy instillation with the bacillus Calmette-Guérin (BCG) vaccine. In a prospective longitudinal study, we took advantage of BCG instillat…

CD127+ innate lymphoid cells are dysregulated in treatment naive acute myeloid leukemia patients at diagnosis Open

Sara Trabanelli, Antonio Curti, Mariangela Lecciso, Bérengère Salomé, Carsten Riether , et al. · 2015

Innate lymphoid cells (ILCs), defined as lineage negative (Lin−) CD127+ cells, have emerged as novel important immune effector cells, playing a critical role also in tumor immunosurveillance.1–5 Recently, it was shown that the number of IL…

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