Berhane Seyoum
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View article: SUN-704 Exploring the Role of Fibroblast Growth Factor-21 as a Predictor of Insulin Resistance and Metabolic Syndrome
SUN-704 Exploring the Role of Fibroblast Growth Factor-21 as a Predictor of Insulin Resistance and Metabolic Syndrome Open
Disclosure: A. Mathew: None. D. Almansour: None. B. Seyoum: None. Introduction: Fibroblast growth factor-21 (FGF 21) is a hormone secreted by hepatic cells and adipose tissue. It binds to a subset of specific receptors and klotho receptors…
View article: 7965 An Extremely Rapid Progression of Anaplastic Thyroid Carcinoma!
7965 An Extremely Rapid Progression of Anaplastic Thyroid Carcinoma! Open
Disclosure: S. Makadsi: None. T. Altaweel: None. B. Seyoum: None. A. Garg: None. Introduction: Anaplastic Thyroid Carcinoma (ATC) is a very rare and aggressive form of thyroid cancer. It mostly occurs in people over 60 years of age, has un…
View article: Alterations in Skeletal Muscle Insulin Signaling DNA Methylation: A Pilot Randomized Controlled Trial of Olanzapine in Healthy Volunteers
Alterations in Skeletal Muscle Insulin Signaling DNA Methylation: A Pilot Randomized Controlled Trial of Olanzapine in Healthy Volunteers Open
Antipsychotics are associated with severe metabolic side effects including insulin resistance; however, the mechanisms underlying this side effect are not fully understood. The skeletal muscle plays a critical role in insulin-stimulated gl…
View article: Effect of Insulin and Pioglitazone on Protein Phosphatase 2A Interaction Partners in Primary Human Skeletal Muscle Cells Derived from Obese Insulin-Resistant Participants
Effect of Insulin and Pioglitazone on Protein Phosphatase 2A Interaction Partners in Primary Human Skeletal Muscle Cells Derived from Obese Insulin-Resistant Participants Open
Skeletal muscle insulin resistance is a major contributor to type-2 diabetes (T2D). Pioglitazone is a potent insulin sensitizer of peripheral tissues by targeting peroxisome proliferator-activated receptor gamma. Pioglitazone has been repo…
View article: The effect of antipsychotic treatment on hormonal, inflammatory, and metabolic biomarkers in healthy volunteers: A systematic review and meta‐analysis
The effect of antipsychotic treatment on hormonal, inflammatory, and metabolic biomarkers in healthy volunteers: A systematic review and meta‐analysis Open
Antipsychotic medications demonstrate a variable range of efficacy and side effects in patients with mental illness. Research has attempted to identify biomarkers associated with antipsychotic effects in various populations. Research desig…
View article: Ceramide changes in abdominal subcutaneous and visceral adipose tissue among diabetic and nondiabetic patients
Ceramide changes in abdominal subcutaneous and visceral adipose tissue among diabetic and nondiabetic patients Open
Background This study profiles ceramides extracted from visceral and subcutaneous adipose tissue of human subjects by liquid chromatography‐mass spectrometry to determine a correlation with status of diabetes and gender. Methods Samples of…
View article: Glycemic control in the critically ill: Less is more
Glycemic control in the critically ill: Less is more Open
Hyperglycemia is associated with poor clinical outcomes in critically ill patients. Initial clinical trials of intensive insulin therapy targeting blood glucose levels of 80 to 110 mg/dL showed improved outcomes, but subsequent trials foun…
View article: Profiling the Skeletal Muscle Proteome in Patients on Atypical Antipsychotics and Mood Stabilizers
Profiling the Skeletal Muscle Proteome in Patients on Atypical Antipsychotics and Mood Stabilizers Open
Atypical antipsychotics (AAP) are used in the treatment of severe mental illness. They are associated with several metabolic side effects including insulin resistance. The skeletal muscle is the primary tissue responsible for insulin-stimu…
View article: Age and Hospitalization Risk in People With Type 1 Diabetes and COVID-19: Data From the T1D Exchange Surveillance Study
Age and Hospitalization Risk in People With Type 1 Diabetes and COVID-19: Data From the T1D Exchange Surveillance Study Open
Context COVID-19 morbidity and mortality are increased in type 1 diabetes (T1D), but few data focus on age-based outcomes. Objective This work aimed to quantify the risk for COVID-19–related hospitalization and adverse outcomes by age in p…
View article: Metformin Increases Protein Phosphatase 2A Activity in Primary Human Skeletal Muscle Cells Derived from Lean Healthy Participants
Metformin Increases Protein Phosphatase 2A Activity in Primary Human Skeletal Muscle Cells Derived from Lean Healthy Participants Open
Context. Skeletal muscle insulin resistance is one of the primary contributors of type 2 diabetes (T2D). Metformin is the first-line drug for the treatment of T2D. The primary effects of metformin include decreasing glucose production in t…
View article: Letter to the editor: Vitamin D levels in acute illness and clinical severity in COVID-19 patients
Letter to the editor: Vitamin D levels in acute illness and clinical severity in COVID-19 patients Open
We would like to comment on the recently published article titled: “Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients” by Ricci et al. The authors grouped the patients into two groups according to the…
View article: Metabolic syndrome and clinical outcomes in patients infected with <scp>COVID</scp>‐19: Does age, sex, and race of the patient with metabolic syndrome matter?
Metabolic syndrome and clinical outcomes in patients infected with <span>COVID</span>‐19: Does age, sex, and race of the patient with metabolic syndrome matter? Open
Background Metabolic syndrome (MetS) is highly prevalent worldwide, and its individual components obesity, diabetes, and hypertension have been identified as risk factors to develop severe coronavirus disease 2019 (COVID‐19); however, data…
View article: Supplementary Table S1.docx
Supplementary Table S1.docx Open
Characteristics of patients by age group based on tertiles with COVID-19 and type 1 diabetes. Data collected April 7, 2020 – March 31, 2021, total N = 767
View article: Vitamin D Deficiency is Associated with Metabolic Syndrome
Vitamin D Deficiency is Associated with Metabolic Syndrome Open
Background: Metabolic syndrome (MetS), insulin resistance (IR) and diabetes mellitus (DM) are highly interrelated abnormalities seeking multidisciplinary public health interventions. Vitamin D has recently gained attention as a protective …
View article: SUN-620 Gender Difference in the Outcome of Patients with Diabetes Admitted for Hyperosmolar Hyperglycemia. from the National Inpatient Sample
SUN-620 Gender Difference in the Outcome of Patients with Diabetes Admitted for Hyperosmolar Hyperglycemia. from the National Inpatient Sample Open
Objective: There is paucity of literature on the impact of gender on outcomes of hyperosmolar hyperglycemic state (HHS) among adult patients with diabetes. The aim of this study was to evaluate the effect of gender on the outcome of these …
View article: SAT-647 The Effectiveness of Insulin Pump Therapy Compared to Multiple Daily Insulin Injections in Type 1 and Type 2 Diabetes Mellitus in a Predominantly African American Population
SAT-647 The Effectiveness of Insulin Pump Therapy Compared to Multiple Daily Insulin Injections in Type 1 and Type 2 Diabetes Mellitus in a Predominantly African American Population Open
Compared to multiple daily insulin injections (MDI), continuous subcutaneous insulin infusion (CSII) has proven to reach target HbA1c level with less frequent hypoglycemia, be more cost-effective, and improve quality of life. However, data…
View article: SUN-611 Impact of Existing Heart Failure on Outcomes of Hospitalization of Hyperosmolar Hyperglycemic State. From the National Inpatient Sample
SUN-611 Impact of Existing Heart Failure on Outcomes of Hospitalization of Hyperosmolar Hyperglycemic State. From the National Inpatient Sample Open
Introduction: Patients with underlying heart failure (HF) are at increased risk for hyperosmolar hyperglycemic state (HHS). However, no studies have investigated whether the presence of existing HF would impact the outcomes of HHS. Objecti…
View article: SUN-625 The Impact of Age on Outcomes of Hyperosmolar Hyperglycemia Among Adult Patients with Diabetes. from the National Inpatient Sample
SUN-625 The Impact of Age on Outcomes of Hyperosmolar Hyperglycemia Among Adult Patients with Diabetes. from the National Inpatient Sample Open
Objective: There is paucity of literature on the impact of age on outcomes hyperosmolar hyperglycemic state (HHS) among adult patients with diabetes. The aim of the study was to evaluate the effect of age on the outcome of patients admitte…
View article: MON-LB116 FGF-21 Is A Reliable Marker Of Insulin Resistance Before The Occurrence Of Glucose Intolerance
MON-LB116 FGF-21 Is A Reliable Marker Of Insulin Resistance Before The Occurrence Of Glucose Intolerance Open
Background and aims: Fibroblast growth factor (FGF)-21 is a polypeptide that results in metabolic rearrangement mostly related to glucose and lipid metabolism. Serum FGF-21 level is elevated in obesity and in type 2 diabetes. The goal of t…
View article: MON-180 Risk for Hypercoagulability Among Patients with Cushing Syndrome. From the National Inpatient Sample
MON-180 Risk for Hypercoagulability Among Patients with Cushing Syndrome. From the National Inpatient Sample Open
Background: Patients with Cushing syndrome are at higher risk for hypercoagulability due to elevated levels of pro-coagulants and impaired fibrinolysis. Objective: We aimed to examine the association of Cushing syndrome and hypercoagulabil…
View article: SAT-559 Patients with Hyperaldosteronism Have Higher Prevalence of Obstructive Sleep Apnea. From the National Inpatient Sample
SAT-559 Patients with Hyperaldosteronism Have Higher Prevalence of Obstructive Sleep Apnea. From the National Inpatient Sample Open
Introduction: Previous studies suggested that aldosterone excess may worsen obstructive sleep apnea (OSA) through causing peri-pharyngeal edema. Objective: In this study we sought to examine if hyperaldosteronism is associated with OSA. Me…
View article: Antipsychotic Medications and DNA Methylation in Schizophrenia and Bipolar Disorder: A Systematic Review
Antipsychotic Medications and DNA Methylation in Schizophrenia and Bipolar Disorder: A Systematic Review Open
The pharmacoepigenetics of antipsychotic treatment in severe mental illness is a growing area of research that aims to understand the interface between antipsychotic treatment and genetic regulation. Pharmacoepigenetics may some day assist…
View article: Kinome Profiling Reveals Abnormal Activity of Kinases in Skeletal Muscle From Adults With Obesity and Insulin Resistance
Kinome Profiling Reveals Abnormal Activity of Kinases in Skeletal Muscle From Adults With Obesity and Insulin Resistance Open
Context Obesity-related insulin resistance (OIR) is one of the main contributors to type 2 diabetes and other metabolic diseases. Protein kinases are implicated in insulin signaling and glucose metabolism. Molecular mechanisms underlying O…
Epigenetic Modifications in Peripheral Blood as Potential Noninvasive Biomarker of Diabetic Retinopathy Open
DNA methylation status in the blood of diabetic patients could serve as a potential noninvasive biomarker of retinopathy, and also an important readout parameter for testing longitudinal outcome of novel therapeutics for this blinding dise…
View article: Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes
Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes Open
Patient-derived progenitor cell (PC) dysfunction is severely impaired in diabetes, but the molecular triggers that contribute to mechanisms of PC dysfunction are not fully understood. Methylglyoxal (MGO) is one of the highly reactive dicar…
View article: Kinome profiling reveals abnormal activity of kinases in skeletal muscle from adults with obesity and insulin resistance
Kinome profiling reveals abnormal activity of kinases in skeletal muscle from adults with obesity and insulin resistance Open
ABSTRACTContext: Obesity-related insulin resistance (OIR) is one of the main contributors to type 2 diabetes and other metabolic diseases. Protein kinases are implicated in insulin signaling and glucose metabolism. Molecular mechanisms und…
View article: Atypical Antipsychotics and the Human Skeletal Muscle Lipidome
Atypical Antipsychotics and the Human Skeletal Muscle Lipidome Open
Atypical antipsychotics (AAPs) are a class of medications associated with significant metabolic side effects, including insulin resistance. The aim of this study was to analyze the skeletal muscle lipidome of patients on AAPs, compared to …
View article: Opposing Effects of IL-1Ra and IL-36Ra on Innate Immune Response to <i>Pseudomonas aeruginosa</i> Infection in C57BL/6 Mouse Corneas
Opposing Effects of IL-1Ra and IL-36Ra on Innate Immune Response to <i>Pseudomonas aeruginosa</i> Infection in C57BL/6 Mouse Corneas Open
Pseudomonas aeruginosa keratitis is characterized by severe corneal ulceration and may lead to blindness if not treated properly in a timely manner. Although the roles of the IL-1 subfamily of cytokines are well established, as a newly dis…
View article: Association of Protein Kinase B (<scp>AKT</scp>) <scp>DNA</scp> Hypermethylation with Maintenance Atypical Antipsychotic Treatment in Patients with Bipolar Disorder
Association of Protein Kinase B (<span>AKT</span>) <span>DNA</span> Hypermethylation with Maintenance Atypical Antipsychotic Treatment in Patients with Bipolar Disorder Open
Study Objective Atypical antipsychotics cause insulin resistance that leads to an increased risk of diabetes mellitus and cardiovascular disease. Skeletal muscle is the primary tissue for uptake of glucose, and its dysfunction is considere…