Bernadette Hotzi
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View article: Publisher Correction: Transposable element methylation tracks age
Publisher Correction: Transposable element methylation tracks age Open
View article: Age‐dependent heat shock hormesis to <scp>HSF</scp>‐1 deficiency suggests a compensatory mechanism mediated by the unfolded protein response and innate immunity in young <i>Caenorhabditis elegans</i>
Age‐dependent heat shock hormesis to <span>HSF</span>‐1 deficiency suggests a compensatory mechanism mediated by the unfolded protein response and innate immunity in young <i>Caenorhabditis elegans</i> Open
The transcription factor HSF‐1 (heat shock factor 1) acts as a master regulator of heat shock response in eukaryotic cells to maintain cellular proteostasis. The protein has a protective role in preventing cells from undergoing ageing, and…
View article: N6-Methyladenine Progressively Accumulates in Mitochondrial DNA during Aging
N6-Methyladenine Progressively Accumulates in Mitochondrial DNA during Aging Open
N6-methyladenine (6mA) in the DNA is a conserved epigenetic mark with various cellular, physiological and developmental functions. Although the presence of 6mA was discovered a few years ago in the nuclear genome of distantly related anima…
View article: Downregulation of transposable elements extends lifespan in Caenorhabditis elegans
Downregulation of transposable elements extends lifespan in Caenorhabditis elegans Open
View article: SignaLink3: a multi-layered resource to uncover tissue-specific signaling networks
SignaLink3: a multi-layered resource to uncover tissue-specific signaling networks Open
Signaling networks represent the molecular mechanisms controlling a cell's response to various internal or external stimuli. Most currently available signaling databases contain only a part of the complex network of intertwining pathways, …
View article: Sex-specific regulation of neuronal functions in Caenorhabditis elegans: the sex-determining protein TRA-1 represses goa-1/Gα(i/o)
Sex-specific regulation of neuronal functions in Caenorhabditis elegans: the sex-determining protein TRA-1 represses goa-1/Gα(i/o) Open
View article: HSF1Base: A Comprehensive Database of HSF1 (Heat Shock Factor 1) Target Genes
HSF1Base: A Comprehensive Database of HSF1 (Heat Shock Factor 1) Target Genes Open
HSF1 (heat shock factor 1) is an evolutionarily conserved master transcriptional regulator of the heat shock response (HSR) in eukaryotic cells. In response to high temperatures, HSF1 upregulates genes encoding molecular chaperones, also c…
View article: Sex‐specific regulation of aging in <i>Caenorhabditis elegans</i>
Sex‐specific regulation of aging in <i>Caenorhabditis elegans</i> Open
Summary A fascinating aspect of sexual dimorphism in various animal species is that the two sexes differ substantially in lifespan. In humans, for example, women's life expectancy exceeds that of men by 3–7 years. Whether this trait can be…
View article: The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms
The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms Open
View article: AUTEN-67 (Autophagy Enhancer-67) Hampers the Progression of Neurodegenerative Symptoms in a Drosophila model of Huntington’s Disease
AUTEN-67 (Autophagy Enhancer-67) Hampers the Progression of Neurodegenerative Symptoms in a Drosophila model of Huntington’s Disease Open
These results imply that AUTEN-67 impedes the progression of neurodegenerative symptoms characterizing HD, and that autophagy is a promising therapeutic target for treating this pathology. In humans, AUTEN-67 may have the potential to dela…