Bernadette Mödl
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View article: TYK2 Promotes Immunosurveillance of Colorectal Cancer Liver Metastasis
TYK2 Promotes Immunosurveillance of Colorectal Cancer Liver Metastasis Open
Colorectal cancer liver metastasis (CRLM) is a major clinical problem. The regulators of immunosurveillance of CRLM could hold potential for developing therapeutic strategies to prevent or treat metastasis. In this study, using a murine co…
View article: Polystyrene micro- and nanoplastics in a colitis mouse model – effects on biodistribution, macrophage polarization, and gut microbiome
Polystyrene micro- and nanoplastics in a colitis mouse model – effects on biodistribution, macrophage polarization, and gut microbiome Open
The increasing prevalence of inflammatory bowel disease (IBD) and rising pollution from micro-and nanoplastic (MNP) particles has prompted investigations on their potential interconnection. To elucidate the complex relationship between IBD…
View article: Loss of SPHK1 fuels inflammation to drive KRAS-mutated lung adenocarcinoma
Loss of SPHK1 fuels inflammation to drive KRAS-mutated lung adenocarcinoma Open
Inflammation is a widely recognized key contributor to KRAS-driven lung adenocarcinoma (LUAD). Tumor-associated macrophages (TAM) are an integral part of the tumor microenvironment and create a supportive niche that sustains inflammation-d…
View article: Polystyrene micro- and nanoplastics aggravates colitis in a mouse model – effects on biodistribution, macrophage polarization, and gut microbiome
Polystyrene micro- and nanoplastics aggravates colitis in a mouse model – effects on biodistribution, macrophage polarization, and gut microbiome Open
Background The increasing prevalence of inflammatory bowel disease (IBD) and rising pollution from micro- and nanoplastic (MNP) particles has prompted investigations on their potential interconnection. To elucidate the complex relationship…
View article: Type I and II interferon signaling in colorectal cancer liver metastasis
Type I and II interferon signaling in colorectal cancer liver metastasis Open
Metastatic colorectal cancer is one of the leading causes of cancer-related deaths worldwide. Traditional chemotherapy extended the lifespan of cancer patients by only a few months, but targeted therapies and immunotherapy prolonged surviv…
View article: The intermicrovillar adhesion complex in gut barrier function and inflammation
The intermicrovillar adhesion complex in gut barrier function and inflammation Open
The surface of intestinal epithelial cells is covered by the brush border, which consists of densely packed cellular extrusions called microvilli. Until recently, microvilli have not been known to be interconnected. In 2014, a protein comp…
View article: Tyk2 is a tumor suppressor in colorectal cancer
Tyk2 is a tumor suppressor in colorectal cancer Open
Janus kinase Tyk2 is implicated in cancer immune surveillance, but its role in solid tumors is not well defined. We used Tyk2 knockout mice (Tyk2Δ/Δ) and mice with conditional deletion of Tyk2 in hematopoietic (Tyk2ΔHem) or intestinal epit…