Explanipedia

Breaking Free From MCHC Interferences? French‐Speaking Cellular Haematology Group (GFHC) Review of Causes, Rising Trends and Practical Solutions Open

Sandrine Girard, Yaël Berda‐Haddad, Chantal Brouzes, Bouchra Badaoui, Agathe Boussaroque , et al. · 2025

Mean corpuscular haemoglobin concentration (MCHC) is determined by the ratio of haemoglobin concentration to haematocrit. Managing increased MCHC presents significant challenges, mainly due to variations in analytical methods and pathophys…

Letter in response to Othman & Favaloro “Comparison of two ways of performing ristocetin-induced platelet agglutination (RIPA) mixing study for diagnosis of type 2B VWD” Open

Reza Soleimani, Mehdi Khourssaji, Julien Cabo, Maïté Guldenpfennig, Justine Baudar , et al. · 2023

Laboratory evaluation of a new integrative assay to phenotype plasma fibrinolytic system Open

Marion Bareille, Michaël Hardy, Bernard Châtelain, Thomas Lecompte, François Mullier · 2022

Pseudothrombocytopenia—A Review on Causes, Occurrence and Clinical Implications Open

Benjamin Lardinois, Julien Favresse, Bernard Châtelain, Giuseppe Lippi, François Mullier · 2021

Pseudothrombocytopenia (PTCP), a relative common finding in clinical laboratories, can lead to diagnostic errors, overtreatment, and further (even invasive) unnecessary testing. Clinical consequences with potential life-threatening events …

Management of the thrombotic risk associated with COVID-19: what is the role of the hemostasis laboratory? Open

Michaël Hardy, Jonathan Douxfils, Jean-Michel Dogné, Sarah Lessire, Bernard Châtelain , et al. · 2020

COVID-19 is associated with disturbances of hemostasis in the laboratory and an increased thrombotic risk. Routine laboratory tests - activated partial thromboplastin time (aPTT), prothrombin time, Clauss fibrinogen and D-dimers levels mea…

Prognostic value of high-sensitivity measurable residual disease assessment after front-line chemoimmunotherapy in chronic lymphocytic leukemia Open

Rémi Letestu, Abdelmalek Dahmani, Marouane Boubaya, Lucile Baseggio, Lydia Campos , et al. · 2020

Management of the thrombotic risk associated with COVID-19: guidance for the hemostasis laboratory Open

Michaël Hardy, Thomas Lecompte, Jonathan Douxfils, Sarah Lessire, Jean‐Michel Dogné , et al. · 2020

Coronavirus disease 2019 (COVID-19) is associated with extreme inflammatory response, disordered hemostasis and high thrombotic risk. A high incidence of thromboembolic events has been reported despite thromboprophylaxis, raising the quest…

Effects of Time-Interval since Blood Draw and of Anticoagulation on Platelet Testing (Count, Indices and Impedance Aggregometry): A Systematic Study with Blood from Healthy Volunteers Open

Michaël Hardy, Sarah Lessire, Sultan Kasikci, Justine Baudar, Maïté Guldenpfennig , et al. · 2020

Platelet count, indices (mean volume, young—immature platelet fraction) and aggregation are widely used laboratory parameters to investigate primary hemostasis. We performed a systematic, thorough evaluation of the influence of the time-in…

Evaluation of a new thromboplastin reagent STA‐NeoPTimal on a STA R Max analyzer for the measurement of prothrombin time, international normalized ratio and extrinsic factor levels Open

François Mullier, Marie‐Sophie Paridaens, Jonathan Evrard, Justine Baudar, Maïté Guldenpfennig , et al. · 2020

Introduction We aimed at evaluating the performance of a new prothrombin time (PT) reagent (STA‐NeoPTimal) with two other PT reagents (STA‐Neoplastine R and STA‐Neoplastine CI Plus) and the reference PT reagent used in our laboratory (Read…

Clustering and kernel density estimation for assessment of measurable residual disease by flow cytometry Open

Hugues Jacqmin, Bernard Châtelain, Quentin Louveaux, Philippe Jacqmin, Jean‐Michel Dogné , et al. · 2020

Flow cytometry raw data and supplementary table S1.

Clustering and kernel density estimation for assessment of measurable residual disease by flow cytometry Open

Hugues Jacqmin, Bernard Châtelain, Quentin Louveaux, Philippe Jacqmin, Jean‐Michel Dogné , et al. · 2020

Flow cytometry raw data and supplementary table S1.

Clustering and Kernel Density Estimation for Assessment of Measurable Residual Disease by Flow Cytometry Open

Hugues Jacqmin, Bernard Châtelain, Quentin Louveaux, Philippe Jacqmin, Jean‐Michel Dogné , et al. · 2020

Standardization, data mining techniques, and comparison to normality are changing the landscape of multiparameter flow cytometry in clinical hematology. On the basis of these principles, a strategy was developed for measurable residual dis…

Platelet Counting: Ugly Traps and Good Advice. Proposals from the French-Speaking Cellular Hematology Group (GFHC) Open

Véronique Baccini, Franck Geneviève, Hugues Jacqmin, Bernard Châtelain, Sandrine Girard , et al. · 2020

Despite the ongoing development of automated hematology analyzers to optimize complete blood count results, platelet count still suffers from pre-analytical or analytical pitfalls, including EDTA-induced pseudothrombocytopenia. Although mo…

Two‐site evaluation of a new workflow for the detection of malignant cells on the Sysmex XN‐1000 body fluid analyzer Open

Julien Favresse, Lidvine Boland, Marie Schellen, Caroline Fervaille, Fabien Wuestenberghs , et al. · 2020

Introduction The presence of high fluorescent cells (HF‐BF) on the Sysmex XN‐1000 hematology analyzers has gained interest regarding the prediction of malignant cells in body fluids, but lacks sensitivity. We aimed to increase this sensiti…

Implementation of a classification strategy of Raman data collected in different clinical conditions: application to the diagnosis of chronic lymphocytic leukemia Open

Michaël Féré, Cyril Gobinet, L. H. Liu, A. Beljebbar, Valérie Untereiner , et al. · 2019

Utility of the XN‐1000 research mode for leukocytes counting in ascitic and pleural fluids Open

Julien Favresse, Caroline Fervaille, Fabien Wuestenberghs, Bernard Châtelain, François Mullier , et al. · 2019

Evaluation of a hereditary spherocytosis screening algorithm by automated blood count using reticulocytes and erythrocytic parameters on the Sysmex XN‐series Open

Jean‐Yves Sottiaux, Julien Favresse, Charles Chevalier, Bernard Châtelain, Hugues Jacqmin , et al. · 2019

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

Prospective and comparative study of paroxysmal nocturnal hemoglobinuria patients treated or not by eculizumab Open

Bérangère Devalet, Adeline Wannez, Nicolas Bailly, Lütfiye Alpan, Damien Gheldof , et al. · 2019

Thrombosis are severe complications of paroxysmal nocturnal hemoglobinuria (PNH), effectively reduced by eculizumab. Extracellular vesicles (EVs) may play a central role. The objective of this study was to assess the procoagulant activity …

Focus on pre-processing step to ensure the clinical transferability of Raman data acquired on lymphocytes in different experimental and instrumental conditions Open

Michaël Féré, Olivier Piot, L.H Liu, A. Beljebbar, Valérie Untereiner , et al. · 2019

PF246 PERSONALIZED FOLLOW‐UP OF ACUTE MYELOID LEUKEMIA THROUGH MULTIPARAMETER FLOW CYTOMETRY: A PROOF OF CONCEPT Open

Hugues Jacqmin, Quentin Louveaux, Bernard Châtelain, P. Jacqmin, C Chatelain , et al. · 2019

Background: Standardization, machine learning techniques and comparison to normality are concepts that are changing the landscape of multiparameter flow cytometry data analysis in clinical hematology. We applied these concepts to the follo…

Extracellular Vesicles in Red Blood Cell Concentrates: An Overview Open

Adeline Wannez, Bérangère Devalet, Bernard Châtelain, C Chatelain, Jean‐Michel Dogné , et al. · 2019

D-dimer: Preanalytical, analytical, postanalytical variables, and clinical applications Open

Julien Favresse, Giuseppe Lippi, Pierre‐Marie Roy, Bernard Châtelain, Hugues Jacqmin , et al. · 2018

D-dimer is a soluble fibrin degradation product deriving from the plasmin-mediated degradation of cross-linked fibrin. D-dimer can hence be considered a biomarker of activation of coagulation and fibrinolysis, and it is routinely used for …

Haemolytic Anaemia in a Patient with Progressive Breast Cancer: Consider Thrombotic Microangiopathies and Treat the Cancer Open

Sabine Bailly, Bernard Châtelain, Vander Borght T, Lionel D’Hondt, Laurence Faugeras · 2018

Background: Haemolytic anaemia secondary to cancer is a rare and potentially fatal cancer complication belonging to the Thrombotic Microangiopathies (TMAs), which include the better known Thrombotic Thrombocytopenic Purpura (TTP) and Haemo…

Betrixaban: Impact on Routine and Specific Coagulation Assays—A Practical Laboratory Guide Open

Romain Siriez, Jonathan Evrard, Jean‐Michel Dogné, Lionel Pochet, Damien Gheldof , et al. · 2018

Introduction Betrixaban is a novel direct oral factor Xa inhibitor approved by the Food and Drug Administration for prophylaxis of venous thromboembolism in adult patients hospitalized for an acute illness at risk for thromboembolic compli…

Evaluation of the Fully Automated HemosIL Acustar ADAMTS13 Activity Assay Open

Julien Favresse, Benjamin Lardinois, Bernard Châtelain, Hugues Jacqmin, François Mullier · 2018

ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 repeats, member 13) is responsible for the proteolysis of ultra-large von Willebrand factor (VWF) multimers into smaller multimers.[1] Thrombotic thrombocytopenic pur…

Evaluation of the DOAC-Stop® Procedure to Overcome the Effect of DOACs on Several Thrombophilia Screening Tests Open

Julien Favresse, Benjamin Lardinois, Lina Sabor, Bérangère Devalet, Julie Vandepapeliere , et al. · 2018

The impact of direct oral anticoagulants (DOACs) on laboratory assays used for thrombophilia testing (e.g., antithrombin, protein S, protein C, lupus anticoagulant and activated protein-C resistance) is a well-known issue and may cause fal…

A reminder of the place of morphology and the H‐score in the diagnosis of hemophagocytic lymphohistiocytosis (<span>HLH</span>) Open

J. Favresse, Benjamin Lardinois, Bernard Châtelain, François Mullier, Hugues Jacqmin · 2018

Key Clinical Message This case report reminds the reader of the place of hemophagocytosis and the H‐Score in the diagnosis of secondary hemophagocytic lymphohistiocytosis.

Application of a clot-based assay to measure the procoagulant activity of stored allogeneic red blood cell concentrates. Open

Bérangère Devalet, Adeline Wannez, Nicolas Bailly, Lütfiye Alpan, Damien Gheldof , et al. · 2018

The STA^®-Procoag-PPL is a potentially useful technique for assessing the procoagulant activity of a red blood cell concentrate.

Perioperative management of patients on direct oral anticoagulants Open

Virginie Dubois, Anne-Sophie Dincq, Jonathan Douxfils, Brigitte Ickx, Charles Marc Samama , et al. · 2017

Influence of apixaban on commonly used coagulation assays: results from the Belgian national External Quality Assessment Scheme Open

Marjan Van Blerk, Els Bailleul, Bernard Châtelain, Anne Demulder, Katrien Devreese , et al. · 2017

Summary Introduction The Belgian national External Quality Assessment Scheme performed a survey to assess the effect of the direct oral anticoagulant apixaban on the coagulation assays prothrombin time ( PT ), activated partial thromboplas…

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