Bernard de Massy
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View article: PRDM9 drives the location and rapid evolution of recombination hotspots in salmonid fish
PRDM9 drives the location and rapid evolution of recombination hotspots in salmonid fish Open
In many eukaryotes, meiotic recombination occurs preferentially at discrete sites, called recombination hotspots. In various lineages, recombination hotspots are located in regions with promoter-like features and are evolutionarily stable.…
View article: eLife Assessment: The recombination landscape of introgression in yeast
eLife Assessment: The recombination landscape of introgression in yeast Open
View article: eLife Assessment: H2A.Z deposition at meiotic prophase I underlies homologous recombination and pachytene genome activation during male meiosis
eLife Assessment: H2A.Z deposition at meiotic prophase I underlies homologous recombination and pachytene genome activation during male meiosis Open
Accurate meiotic progression is important for gamete formation and the generation of genetic diversity. However, little is known about the identity of chromatin regulators that underlie mammalian meiosis in vivo. Here, we identify the mult…
View article: FIGNL1-FIRRM is essential for meiotic recombination and prevents DNA damage-independent RAD51 and DMC1 loading
FIGNL1-FIRRM is essential for meiotic recombination and prevents DNA damage-independent RAD51 and DMC1 loading Open
View article: The TOPOVIBL meiotic DSB formation protein: new insights from its biochemical and structural characterization
The TOPOVIBL meiotic DSB formation protein: new insights from its biochemical and structural characterization Open
The TOPOVIL complex catalyzes the formation of DNA double strand breaks (DSB) that initiate meiotic homologous recombination, an essential step for chromosome segregation and genetic diversity during gamete production. TOPOVIL is composed …
View article: Principles of chromosome organization for meiotic recombination
Principles of chromosome organization for meiotic recombination Open
View article: eLife Assessment: The recombination landscape of introgression in yeast
eLife Assessment: The recombination landscape of introgression in yeast Open
Meiotic recombination is an important evolutionary force that acts by breaking up genomic linkage, thereby increasing the efficacy of selection. Meiotic recombination is initiated with a double-strand break which is resolved via a crossove…
View article: Principles of chromosome organization for meiotic recombination
Principles of chromosome organization for meiotic recombination Open
SUMMARY In meiotic cells, chromosomes are organized as chromatin loop arrays anchored to a protein axis. This organization is essential to regulate meiotic recombination, from DNA double-strand break (DSB) formation to their repair 1 . In …
View article: PRDM9 drives the location and rapid evolution of recombination hotspots in salmonids
PRDM9 drives the location and rapid evolution of recombination hotspots in salmonids Open
In many eukaryotes, meiotic recombination occurs preferentially at discrete sites, called recombination hotspots. In various lineages, recombination hotspots are located in regions with promoter-like features and are evolutionarily stable.…
View article: eLife assessment: Control of meiotic entry by dual inhibition of a key mitotic transcription factor
eLife assessment: Control of meiotic entry by dual inhibition of a key mitotic transcription factor Open
Full text Figures and data Side by side Abstract eLife assessment Introduction Results Discussion Materials and methods Data availability References Peer review Author response Article and author information Metrics Abstract The mitosis to…
View article: eLife Assessment: Control of meiotic entry by dual inhibition of a key mitotic transcription factor
eLife Assessment: Control of meiotic entry by dual inhibition of a key mitotic transcription factor Open
The mitosis to meiosis transition requires dynamic changes in gene expression, but whether and how the mitotic transcriptional machinery is regulated during this transition is unknown. In budding yeast, SBF and MBF transcription factors in…
View article: Mutation hotspots during meiosis
Mutation hotspots during meiosis Open
Multiple pathways generate mutations at sites of meiotic recombination in humans
View article: TOPOVIBL function in meiotic DSB formation: new insights from its biochemical and structural characterization
TOPOVIBL function in meiotic DSB formation: new insights from its biochemical and structural characterization Open
The TOPOVIL complex catalyzes the formation of DNA double strand breaks (DSB) that initiate meiotic homologous recombination, an essential step for chromosome segregation and genetic diversity during gamete production. TOPOVIL is composed …
View article: Characterization of the <scp>REC114‐MEI4‐IHO1</scp> complex regulating meiotic <scp>DNA</scp> double‐strand break formation
Characterization of the <span>REC114‐MEI4‐IHO1</span> complex regulating meiotic <span>DNA</span> double‐strand break formation Open
View article: The FIGNL1-FIRRM complex is required to complete meiotic recombination in the mouse and prevents massive DNA damage-independent RAD51 and DMC1 loading
The FIGNL1-FIRRM complex is required to complete meiotic recombination in the mouse and prevents massive DNA damage-independent RAD51 and DMC1 loading Open
During meiosis, nucleoprotein filaments of the strand exchange proteins RAD51 and DMC1 are crucial for repairing SPO11-generated DNA double-strand breaks (DSBs) by homologous recombination (HR). A balanced activity of positive and negative…
View article: Characterization of the REC114-MEI4-IHO1 complex regulating meiotic DNA double-strand break formation
Characterization of the REC114-MEI4-IHO1 complex regulating meiotic DNA double-strand break formation Open
Meiotic recombination is initiated by the formation of DNA double-strand breaks (DSBs), essential for fertility and genetic diversity. In the mouse, DSBs are formed by the catalytic TOPOVIL complex consisting of SPO11 and TOPOVIBL. To pres…
View article: Editor's evaluation: Down the Penrose stairs, or how selection for fewer recombination hotspots maintains their existence
Editor's evaluation: Down the Penrose stairs, or how selection for fewer recombination hotspots maintains their existence Open
Full text Figures and data Side by side Abstract Editor's evaluation Introduction Model Results Discussion Appendix 1 Appendix 2 Appendix 3 Appendix 4 Appendix 5 Data availability References Decision letter Author response Article and auth…
View article: Decision letter: Down the Penrose stairs, or how selection for fewer recombination hotspots maintains their existence
Decision letter: Down the Penrose stairs, or how selection for fewer recombination hotspots maintains their existence Open
Full text Figures and data Side by side Abstract Editor's evaluation Introduction Model Results Discussion Appendix 1 Appendix 2 Appendix 3 Appendix 4 Appendix 5 Data availability References Decision letter Author response Article and auth…
View article: TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks
TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks Open
View article: Evolution and Diversity of the TopoVI and TopoVI-like Subunits With Extensive Divergence of the TOPOVIBL subunit
Evolution and Diversity of the TopoVI and TopoVI-like Subunits With Extensive Divergence of the TOPOVIBL subunit Open
Type II DNA topoisomerases regulate topology by double-stranded DNA cleavage and ligation. The TopoVI family of DNA topoisomerase, first identified and biochemically characterized in Archaea, represents, with TopoVIII and mini-A, the type …
View article: Decision letter: BRCA1/BRC-1 and SMC-5/6 regulate DNA repair pathway engagement during Caenorhabditis elegans meiosis
Decision letter: BRCA1/BRC-1 and SMC-5/6 regulate DNA repair pathway engagement during Caenorhabditis elegans meiosis Open
View article: Editor's evaluation: BRCA1/BRC-1 and SMC-5/6 regulate DNA repair pathway engagement during Caenorhabditis elegans meiosis
Editor's evaluation: BRCA1/BRC-1 and SMC-5/6 regulate DNA repair pathway engagement during Caenorhabditis elegans meiosis Open
View article: Evolution and diversity of the TopoVI and TopoVI-like subunits with extensive divergence of the TOPOVIBL subunit
Evolution and diversity of the TopoVI and TopoVI-like subunits with extensive divergence of the TOPOVIBL subunit Open
Type II DNA topoisomerases regulate topology by double-stranded DNA cleavage and ligation. The TopoVI family of DNA topoisomerase, first identified and biochemically characterized in Archaea, represents, with TopoVIII and mini-A, the type …
View article: Coupling crossover and synaptonemal complex in meiosis
Coupling crossover and synaptonemal complex in meiosis Open
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View article: Coupling crossover and synaptonemal complex in meiosis
Coupling crossover and synaptonemal complex in meiosis Open
During meiosis, a molecular program induces DNA double-strand breaks (DSBs) and their repair by homologous recombination. DSBs can be repaired with or without crossovers. ZMM proteins promote the repair toward crossover. The sites of DSB r…
View article: TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks
TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks Open
Meiosis requires the formation of programmed DNA double strand breaks (DSBs), essential for fertility and for generating genetic diversity. DSBs are induced by the catalytic activity of the TOPOVIL complex formed by SPO11 and TOPOVIBL. To …
View article: Decision letter: Analysis of meiosis in Pristionchus pacificus reveals plasticity in homolog pairing and synapsis in the nematode lineage
Decision letter: Analysis of meiosis in Pristionchus pacificus reveals plasticity in homolog pairing and synapsis in the nematode lineage Open
View article: Chromosome Organization in Early Meiotic Prophase
Chromosome Organization in Early Meiotic Prophase Open
One of the most fascinating aspects of meiosis is the extensive reorganization of the genome at the prophase of the first meiotic division (prophase I). The first steps of this reorganization are observed with the establishment of an axis …
View article: Four-pronged negative feedback of DSB machinery in meiotic DNA-break control in mice
Four-pronged negative feedback of DSB machinery in meiotic DNA-break control in mice Open
In most taxa, halving of chromosome numbers during meiosis requires that homologous chromosomes (homologues) pair and form crossovers. Crossovers emerge from the recombination-mediated repair of programmed DNA double-strand breaks (DSBs). …
View article: Transcriptome and translatome co-evolution in mammals
Transcriptome and translatome co-evolution in mammals Open