Bernard Desderius
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View article: Comparing <i>Life’s Simple Seven</i> between newly diagnosed, ART-naive people living with HIV and HIV-uninfected adults in Tanzania: clues for cardiovascular disease prevention
Comparing <i>Life’s Simple Seven</i> between newly diagnosed, ART-naive people living with HIV and HIV-uninfected adults in Tanzania: clues for cardiovascular disease prevention Open
Cardiovascular disease (CVD) represents a major cause of premature mortality in people living with HIV (PLWH). There is a need to characterize the cardiovascular health profiles of PLWH to appropriately guide primary prevention efforts, pa…
View article: Causes and Consequences of Persistent Anemia after 6 Months of Antiretroviral Therapy in Tanzania: An Observational Comparative Cohort Study
Causes and Consequences of Persistent Anemia after 6 Months of Antiretroviral Therapy in Tanzania: An Observational Comparative Cohort Study Open
Anemia is common among people living with HIV (PLWH), particularly in Africa. Outcomes for PLWH on modern antiretroviral therapy (ART) regimens are not well documented. We conducted an observational study to determine the outcomes and pred…
View article: Virological impact of HIV drug-resistance testing in children, adolescents, and adults failing first-line ART in Tanzania
Virological impact of HIV drug-resistance testing in children, adolescents, and adults failing first-line ART in Tanzania Open
Conducting HIV drug-resistance testing, and switch to individualised second-line regimens did not significantly improve virological suppression in patients experiencing first-line ART failure in Tanzania.
View article: Characterizing blood pressure trajectories in people living with HIV following antiretroviral therapy: A systematic review
Characterizing blood pressure trajectories in people living with HIV following antiretroviral therapy: A systematic review Open
Objectives The advent of antiretroviral therapy (ART) has reduced AIDS‐related morbidity and mortality among people living with HIV (PLWH). Due to increased survival, PLWH have now been found to be at risk of chronic conditions related to …
View article: Translating Ethics into Practice: Providing Long-Term Cardiometabolic and Cardiovascular Disease Care for Research Participants in Africa
Translating Ethics into Practice: Providing Long-Term Cardiometabolic and Cardiovascular Disease Care for Research Participants in Africa Open
In sub-Saharan Africa (SSA), health systems face significant challenges responding to the growing burden of cardiometabolic and cardiovascular diseases (CVDs) [1,2], and most adults in SSA lack access to primary care [3].Consequently, many…
View article: Primary resistance against integrase strand transfer inhibitors in integrase strand transfer inhibitor-naive patients failing first- and second-line ART in Tanzania
Primary resistance against integrase strand transfer inhibitors in integrase strand transfer inhibitor-naive patients failing first- and second-line ART in Tanzania Open
Introduction Sub-Saharan African countries are introducing integrase strand transfer inhibitors (INSTIs) in their ART programmes as the preferred first-line regimen, and dolutegravir is the INSTI of choice due to its potency, tolerability …
View article: Prevalence and patterns of HIV drug resistance in patients with suspected virological failure in North-Western Tanzania
Prevalence and patterns of HIV drug resistance in patients with suspected virological failure in North-Western Tanzania Open
Background More than 15 million people in sub-Saharan Africa receive ART. Treatment failure is common, but the role of HIV drug resistance in treatment failure is largely unknown because drug resistance testing is not routinely done. This …
View article: Sex‐dependent correlates of arterial stiffness in Tanzanian adults
Sex‐dependent correlates of arterial stiffness in Tanzanian adults Open
Objective Arterial stiffness is a known indicator for cardiovascular disease. However, the factors that lead to arterial stiffening have primarily been studied in participants from high‐income countries. Here, we examine clinical and lifes…
View article: Nocturnal dipping of heart rate and blood pressure in people with HIV in Tanzania
Nocturnal dipping of heart rate and blood pressure in people with HIV in Tanzania Open
People with HIV (PWH) have a >2‐fold greater risk for development of cardiovascular disease (CVD), which may be associated with abnormalities in 24‐h ambulatory blood pressure measurement (ABPM) profile. We conducted a nested case‐control …
View article: Blood pressure, T cells, and mortality in people with HIV in Tanzania during the first 2 years of antiretroviral therapy
Blood pressure, T cells, and mortality in people with HIV in Tanzania during the first 2 years of antiretroviral therapy Open
Cardiovascular disease is now a leading cause of mortality in people with HIV (PWH). High blood pressure is the major driver of cardiovascular disease. Despite this, little is known about blood pressure in PWH during the early years of ant…
View article: Human Immunodeficiency Virus–Associated Myocardial Diastolic Dysfunction and Soluble ST2 Concentration in Tanzanian Adults: A Cross-Sectional Study
Human Immunodeficiency Virus–Associated Myocardial Diastolic Dysfunction and Soluble ST2 Concentration in Tanzanian Adults: A Cross-Sectional Study Open
Background The aims of this study were (1) to compare the prevalence of myocardial diastolic dysfunction (DD) in antiretroviral therapy (ART)–naive people living with human immunodeficiency virus (PLWH) to human immunodeficiency virus (HIV…
View article: Disseminated cryptococcosis in a HIV-negative patient: Case report of a newly diagnosed hypertensive adult presenting with hemiparesis
Disseminated cryptococcosis in a HIV-negative patient: Case report of a newly diagnosed hypertensive adult presenting with hemiparesis Open
We report a case of disseminated cryptococcosis in a 42-year old immunocompetent female. Prior to admission at Bugando Medical Center, the patient was attended at three hospitals for hypertension and clinically diagnosed malaria. Following…
View article: Depression screening in HIV-positive Tanzanian adults: comparing the PHQ-2, PHQ-9 and WHO-5 questionnaires
Depression screening in HIV-positive Tanzanian adults: comparing the PHQ-2, PHQ-9 and WHO-5 questionnaires Open
Background. HIV-positive individuals are at significantly increased risk of depression. In low- and middle-income countries, depression is frequently under-detected, hampered by a lack of data regarding available screening tools. The 5-ite…