Bernard Dujon
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View article: Yeasty Memories, Yeast Genomes and Beyond –From Controversy to Collaboration
Yeasty Memories, Yeast Genomes and Beyond –From Controversy to Collaboration Open
We trace over 60 years of yeast genetics research, and conference history highlighting how Saccharomyces cerevisiae evolved from an obscure agent of organic fermentation, to one of the most, if not the most well studied eukaryotic organism…
View article: Functional variability in adhesion and flocculation of yeast megasatellite genes
Functional variability in adhesion and flocculation of yeast megasatellite genes Open
Megasatellites are large tandem repeats found in all fungal genomes but especially abundant in the opportunistic pathogen Candida glabrata. They are encoded in genes involved in cell–cell interactions, either between yeasts or between yeas…
View article: Functional variability in adhesion and flocculation of yeast megasatellite genes
Functional variability in adhesion and flocculation of yeast megasatellite genes Open
Megasatellites are large tandem repeats found in all fungal genomes but especially abundant in the opportunistic pathogen Candida glabrata . They are encoded in genes involved in cell-cell interactions, either between yeasts or between yea…
View article: Hijacking, arms race, GMOs and pesticides
Hijacking, arms race, GMOs and pesticides Open
International audience
View article: The Formation of Neochromosomes during Experimental Evolution in the Yeast Saccharomyces cerevisiae
The Formation of Neochromosomes during Experimental Evolution in the Yeast Saccharomyces cerevisiae Open
Novel, large-scale structural mutations were previously discovered during the cultivation of engineered Saccharomyces cerevisiae strains in which essential tRNA synthetase genes were replaced by their orthologs from the distantly related y…
View article: On the origin of the genetic code: a 27-codon hypothetical precursor of an intricate 64-codon intermediate shaped the modern code
On the origin of the genetic code: a 27-codon hypothetical precursor of an intricate 64-codon intermediate shaped the modern code Open
The modern genetic code reveals numerous traces of specific relationships between the early codons which, together with its internal asymmetries, suggest a sequential appearance of the nucleobases in primitive RNA molecules. Keeping the hy…
View article: The unlimited editing of nucleic acids in the oceans
The unlimited editing of nucleic acids in the oceans Open
International audience
View article: Conclusion
Conclusion Open
Conclusion C.1. Risk and the perception of riskPutting into action the possibilities now emerging through the current trajectories of genetics raises a legitimate apprehension.How do we predict the behavior of synthetic or semi-synthetic o…
View article: My route to the intimacy of genomes
My route to the intimacy of genomes Open
Being invited by a prestigious journal to write the retrospective of one's life is first a great honor, and then a chore when starting to do it. These feelings did not spare me. But trying to recall my past to the best of my memory, I lear…
View article: Genome Diversity and Evolution in the Budding Yeasts (Saccharomycotina)
Genome Diversity and Evolution in the Budding Yeasts (Saccharomycotina) Open
Considerable progress in our understanding of yeast genomes and their evolution has been made over the last decade with the sequencing, analysis, and comparisons of numerous species, strains, or isolates of diverse origins. The role played…
View article: Massive Amplification at an Unselected Locus Accompanies Complex Chromosomal Rearrangements in Yeast
Massive Amplification at an Unselected Locus Accompanies Complex Chromosomal Rearrangements in Yeast Open
Gene amplification has been observed in different organisms in response to environmental constraints, such as limited nutrients or exposure to a variety of toxic compounds, conferring them with specific phenotypic adaptations via increased…
View article: Basic principles of yeast genomics, a personal recollection: Graphical Abstract Figure.
Basic principles of yeast genomics, a personal recollection: Graphical Abstract Figure. Open
The genomes of many yeast species or strain isolates have now been sequenced with an accelerating momentum that quickly relegates initial data to history, albeit that they are less than two decades old. Today, novel yeast genomes are entir…