Bernard Jost
YOU?
Author Swipe
View article: Mitotic chromosome condensation resets chromatin to safeguard transcriptional homeostasis during interphase
Mitotic chromosome condensation resets chromatin to safeguard transcriptional homeostasis during interphase Open
Mitotic entry correlates with the condensation of the chromosomes, changes in histone modifications, exclusion of transcription factors from DNA, and the broad downregulation of transcription. However, whether mitotic condensation influenc…
View article: Mitotic chromosome condensation resets chromatin to maintain transcriptional homeostasis
Mitotic chromosome condensation resets chromatin to maintain transcriptional homeostasis Open
Mitotic entry correlates with the condensation of the chromosomes, remodeling of histone modifications, exclusion of transcription factors from DNA and the broad downregulation of transcription. However, whether mitotic condensation influe…
View article: Waves of sumoylation support transcription dynamics during adipocyte differentiation
Waves of sumoylation support transcription dynamics during adipocyte differentiation Open
Tight control of gene expression networks required for adipose tissue formation and plasticity is essential for adaptation to energy needs and environmental cues. However, the mechanisms that orchestrate the global and dramatic transcripti…
View article: Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells
Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells Open
Our understanding of cell fate decisions in hematopoietic stem cells is incomplete. Here, we show that the transcription factor Helios is highly expressed in murine hematopoietic stem and progenitor cells (HSPCs), where it is required to s…
View article: CD4<sup>+</sup>T cells require Ikaros to inhibit their differentiation toward a pathogenic cell fate
CD4<sup>+</sup>T cells require Ikaros to inhibit their differentiation toward a pathogenic cell fate Open
Significance The production of proinflammatory cytokines, particularly granulocyte-macrophage colony-stimulating factor, by CD4 + T cells is a key process for amplifying immune responses but can also lead to harmful tissue damage in pathol…
View article: Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network
Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network Open
Objective Mice lacking the bHLH transcription factor (TF) Neurog3 do not form pancreatic islet cells, including insulin secreting beta cells, causing diabetes. In human, homozygous mutations of NEUROG3 manifest with neonatal or childhood d…
View article: Waves of sumoylation support transcription dynamics during adipocyte differentiation
Waves of sumoylation support transcription dynamics during adipocyte differentiation Open
Summary Tight control of gene expression networks required for adipose tissue formation and plasticity is essential for adaptation to energy needs and environmental cues. However, little is known about the mechanisms that orchestrate the d…
View article: RNA profiling of human testicular cells identifies syntenic lncRNAs associated with spermatogenesis
RNA profiling of human testicular cells identifies syntenic lncRNAs associated with spermatogenesis Open
STUDY QUESTION Is the noncoding transcriptional landscape during spermatogenesis conserved between human and rodents? SUMMARY ANSWER We identified a core group of 113 long noncoding RNAs (lncRNAs) and 20 novel genes dynamically and synteni…
View article: Combinatorial DNA methylation codes at repetitive elements
Combinatorial DNA methylation codes at repetitive elements Open
DNA methylation is an essential epigenetic modification, present in both unique DNA sequences and repetitive elements, but its exact function in repetitive elements remains obscure. Here, we describe the genome-wide comparative analysis of…
View article: Extensive Regulation of Diurnal Transcription and Metabolism by Glucocorticoids
Extensive Regulation of Diurnal Transcription and Metabolism by Glucocorticoids Open
Altered daily patterns of hormone action are suspected to contribute to metabolic disease. It is poorly understood how the adrenal glucocorticoid hormones contribute to the coordination of daily global patterns of transcription and metabol…