Bernard Jover
YOU?
Author Swipe
Gut alterations in a chronic kidney disease rat model with diet‐induced vascular calcification Open
Intestinal disorders and vascular calcification (VC) are often associated with chronic kidney disease (CKD). While gut barrier alterations have been reported in CKD (such as abnormal intestinal permeability, bacterial overgrowth, and infla…
Heart dysfunction in a rat model with autosomal recessive polycystic kidney disease Open
Autosomal recessive polycystic kidney disease (ARPKD) is a congenital hepatorenal fibrocystic pathology and is one of the most significant childhood nephropathies leading to chronic kidney disease (CKD). While kidney damage has been well s…
#2359 Kinetic modifications in cardiac remodeling in a rat model of CKD Open
Background and Aims The bi-directional relationship between the kidneys and heart leads to different forms of cardiorenal syndrome (CRS) in which acute or chronic dysfunction in one organ affects the other. CRS type 4 is characterized by c…
Cafeteria Diet-Induced Obesity Worsens Experimental CKD Open
Obesity is a significant risk factor for chronic kidney disease (CKD). This study aimed to evaluate the impact of obesity on the development of kidney fibrosis in a model of cafeteria diet rats undergoing 5/6th nephrectomy (SNx). Collagen …
View article: Implications of Senescent Cell Burden and NRF2 Pathway in Uremic Calcification: A Translational Study
Implications of Senescent Cell Burden and NRF2 Pathway in Uremic Calcification: A Translational Study Open
Increased senescent cell burden and dysregulation of the nuclear factor erythroid 2–related factor 2 (NRF2) pathway have been associated with numerous age-related pathologies; however, their role in promoting vascular calcification (VC) in…
Vascular calcification in different arterial beds in ex vivo ring culture and in vivo rat model Open
Vascular calcification is a risk factor for cardiovascular and kidney diseases. Medial calcification may differently affect the arterial tree depending on vessel location and smooth muscle injury. The aim was to map the anatomical distribu…
View article: MO550: Vascular Cells Senescence and Modifications in NRF2 Pathway in a Model of URaEMIC Vascular Calcification
MO550: Vascular Cells Senescence and Modifications in NRF2 Pathway in a Model of URaEMIC Vascular Calcification Open
BACKGROUND AND AIMS Vascular dysfunction including vascular calcification (VC), is a consequence of ageing and chronic kidney disease (CKD) that increase the risk of cardiovascular events. Accumulation of senescent cells in arteries can le…
MO583: Cafeteria Diet-Induced Obesity Worsens Experimental CKD Open
BACKGROUND AND AIMS Obesity is an important risk factor for chronic kidney disease (CKD). It carries hemodynamic and morphologic changes in the kidney resulting in renal function reduction. CKD is associated with glomerulosclerosis and tub…
MO072: PST3.1A, An Inhibitor of MGAT5 Decreases Renal Fibrosis in a Rat Model of Chronic Kidney Disease Open
BACKGROUND AND AIMS Renal fibrosis is a main feature of chronic kidney disease (CKD) that participates in its progression to the end stage.(1) N-acetylglucosaminyltransferase 5 (MGAT5) adds N-acetylglucosamines to newly synthesized glycopr…
Vascular Calcification in Different Arterial Beds in Ex Vivo Ring Culture and in Vivo Rat Model Open
Background .Vascular calcification is a risk factor for cardiovascular and kidney diseases. Medial calcification may differently affect the arterial tree depending on vessel location and smooth muscle injury. Objective .The aim was to map …
Diets Rich in Olive Oil, Palm Oil, or Lard Alter Mitochondrial Biogenesis and Mitochondrial Membrane Composition in Rat Liver Open
Palm oil (crude or refined) and lard are rich in SFA, while olive oil is rich in polyunsaturated fatty acids. SFA are considered harmful to health, while polyunsaturated fatty acids are beneficial to health. The aim of this study was to de…
Study of isoforms of nicotinamide adenine dinucleotide phosphate oxidase of the heart in a model of rats fed on several vegetable oils Open
Palm oil has long been incriminated in obesity, and this obesity would be responsible for the development of cardiac fibrosis, several authors have evoked the role of free radicals in the pathophysiological mechanism of the fibrotic respon…
Effects of high-fat diets on inflammation and antioxidant status in rats : comparison between palm olein and olive oil Open
Palm olein (PO) and olive oil (OO) are widely consumed in the world. PO is considered harmful to health, whereas OO is considered healthy. The aim of the study was to compare the effects of consumption of these oils on antioxidant status a…
Peripancreatic Adipose Tissue Remodeling and Inflammation during High Fat Intake of Palm Oils or Lard in Rats Open
Excessive fat consumption leads to the development of ectopic adipose tissues, affecting the organs they surround. Peripancreatic adipose tissue is implicated in glucose homeostasis regulation and can be impaired in obesity. High palm oil …
View article: MO056MODIFICATION OF P16, P21 AND NRF2 EXPRESSION IN A MODEL OF UREMIC VASCULAR CALCIFICATION
MO056MODIFICATION OF P16, P21 AND NRF2 EXPRESSION IN A MODEL OF UREMIC VASCULAR CALCIFICATION Open
Background and Aims Vascular calcification (VC) is a consequence of ageing that confers development of future cardiovascular events. Accumulation of senescent cells can lead to structural and functional abnormalities in vessel wall towards…
Optimisation of cell and ex vivo culture conditions to study vascular calcification Open
Medial vascular calcification (MVC) is a highly prevalent disease associated with a high risk of severe, potentially lethal, complications. While animal studies may not systematically be circumvented, in vitro systems have been proven usef…
Supplementation with a Bioactive Melon Concentrate in Humans and Animals: Prevention of Oxidative Damages and Fatigue in the Context of a Moderate or Eccentric Physical Activity Open
Exercise is recognized to provide both physical and psychological health benefits. However, oxidative stress can occur and induce muscular damages. SOD B®; M is a melon concentrate, well known to counteract oxidative stress and prevent its…
Supplementation with a bioactive melon concentrate in humans and animals: prevention of oxidative damages and fatigue in the context of a moderate or eccentric physical activity Open
Background: Physical activity is recognized to provide both physical and psychological health benefits. However, oxidative stress can occur in case of poor adaptation to effort and reduce training effectiveness inducing muscular and joint …
Effect of spirulina and silicon‐enriched spirulina on metabolic syndrome features, oxidative stress and mitochondrial activity in Zucker fatty rats Open
The use of Spirulina platensis (Sp) as a functional food was suggested decades ago. Biological incorporation of Silicon (Si) into Sp increases its bioavailability for potential food supplement applications. This work aimed at determining t…
SP399INFLUENCE OF METABOLIC SYNDROME IN A 5/6 NEPHRECTOMY RAT MODEL OF CHRONIC KIDNEY DISEASE Open
International audience
Long‐Term Measures of Dyslipidemia, Inflammation, and Oxidative Stress in Rats Fed a High‐Fat/High‐Fructose Diet Open
Inflammation and oxidative stress are thought to be involved in, or associated with, the development of obesity, dyslipidemia, hepatic steatosis, and insulin resistance. This work was designed to determine the evolution of inflammation and…
sST2 as a New Biomarker of Chronic Kidney Disease-Induced Cardiac Remodeling: Impact on Risk Prediction Open
Heart failure is the most frequent cardiac complication of chronic kidney disease (CKD). Biomarkers help identify high-risk patients. Natriuretic peptides (BNP and NT-proBNP) are largely used for monitoring patients with cardiac failure bu…
Geographical Variations in Blood Pressure Level and Seasonality in Hemodialysis Patients Open
Seasons and climate influence the regulation of blood pressure (BP) in the general population and in hemodialysis patients. It is unknown whether this phenomenon varies across the world. Our objective was to estimate BP seasonality in hemo…
MP116GEOGRAPHICAL AND CLIMATIC VARIATIONS OF BLOOD PRESSURE IN HEMODIALYSIS PATIENTS Open
INTRODUCTION AND AIMS: Hereditary risk factors are important predictors of essential hypertension (EH) and type 2 diabetes (DM2), defining development, course and prognosis of these diseases.Considering the important role of genetic disord…