Bernard Khoo
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View article: SUN-536 Gestational Weight Gain and Pregnancy Outcomes in Women with a History of Bariatric Surgery at Imperial College Healthcare NHS Trust, London, UK
SUN-536 Gestational Weight Gain and Pregnancy Outcomes in Women with a History of Bariatric Surgery at Imperial College Healthcare NHS Trust, London, UK Open
Disclosure: S. Ansari: None. M. Xia: None. R. Valaiyapathi: None. K. Alexiadou: None. R. Houghton: None. C. Bovill-Taylor: None. K. O’Donnell: None. C. Price: None. C. Tsironis: None. S. Pukayastha: None. A. Ahmed: None. R. Agha-Jaffar: No…
View article: OR07-07 Once Daily Low Dose Prednisolone/Prednisone Improves Cardiometabolic Profiles in Adrenal Insufficiency: A Double Blind Randomised Crossover Trial
OR07-07 Once Daily Low Dose Prednisolone/Prednisone Improves Cardiometabolic Profiles in Adrenal Insufficiency: A Double Blind Randomised Crossover Trial Open
Disclosure: S. Choudhury: None. K. Lazarus: None. A. Sharma: None. K. Narula: None. C. Go: None. S. Cro: None. T. Thaventhiran: None. B. Khoo: None. T. Tan: None. K. Meeran: None. Background: Prednisolone is the active and biochemically eq…
View article: [68Ga]Ga-DOTA-TATE PET/CT Improves Accuracy and Guides Management in Multiple Endocrine Neoplasia (MEN1) Patients with Suspected Duodeno-Pancreatic Neuroendocrine Tumours
[68Ga]Ga-DOTA-TATE PET/CT Improves Accuracy and Guides Management in Multiple Endocrine Neoplasia (MEN1) Patients with Suspected Duodeno-Pancreatic Neuroendocrine Tumours Open
Purpose To evaluate the added benefit and accuracy of [ 68 Ga]Ga-DOTA-TATE PET/CT scans in detecting duodeno-pancreatic neuroendocrine tumours (dpNETs) compared to conventional cross-sectional imaging with CT or MRI scans in patients with …
View article: A randomised double-blind crossover study: once-daily low-dose prednisolone compared with thrice-daily hydrocortisone in adrenal insufficiency
A randomised double-blind crossover study: once-daily low-dose prednisolone compared with thrice-daily hydrocortisone in adrenal insufficiency Open
Introduction: Thrice-daily hydrocortisone is the most popular glucocorticoid replacement regimen, followed by prednisolone, for adrenal insufficiency.1 Prednisolone offers a once-daily option, with a more physiological serum profile.2 Alth…
View article: Reassessing the role of the p.(Arg304Gln) missense <i>AIP</i> variant in pituitary tumorigenesis
Reassessing the role of the p.(Arg304Gln) missense <i>AIP</i> variant in pituitary tumorigenesis Open
Objective Heterozygous germline loss-of-function variants in AIP are associated with young-onset growth hormone and/or prolactin-secreting pituitary tumours. However, the pathogenic role of the c.911G > A; p.(Arg304Gln) (R304Q) AIP vari…
View article: 177Lu-DOTATATE peptide receptor radionuclide therapy (PRRT) in metastatic phaeochromocytomas and paragangliomas (mPPGL): a single centre retrospective analysis of experience at an ENETS Centre of Excellence
177Lu-DOTATATE peptide receptor radionuclide therapy (PRRT) in metastatic phaeochromocytomas and paragangliomas (mPPGL): a single centre retrospective analysis of experience at an ENETS Centre of Excellence Open
Introduction 177 Lu-DOTATATE peptide receptor radionuclide therapy (PRRT) represents a possible therapeutic option for patients with metastatic inoperable phaeochromocytomas (PCC) and paragangliomas (PGL) who demonstrate adequate somatosta…
View article: Neuroendocrine tumours and pregnancy: Real‐world data from an European Neuroendocrine Tumour <i>Centre of Excellence</i>
Neuroendocrine tumours and pregnancy: Real‐world data from an European Neuroendocrine Tumour <i>Centre of Excellence</i> Open
Neuroendocrine neoplasms (NENs) arise from the diffuse endocrine system and have been considered to be rare. However, the incidence and prevalence of these tumours have increased in recent years, and they are being seen in younger patients…
View article: Author Correction: Targeting the incretin system in obesity and type 2 diabetes mellitus
Author Correction: Targeting the incretin system in obesity and type 2 diabetes mellitus Open
View article: Society for Endocrinology guidelines for the diagnosis and management of post-bariatric hypoglycaemia
Society for Endocrinology guidelines for the diagnosis and management of post-bariatric hypoglycaemia Open
Post-bariatric hypoglycaemia (PBH) is typically a post-prandial hypoglycaemia occurring about 2–4 h after eating in individuals who have undergone bariatric surgery. PBH develops relatively late after surgery and often after discharge from…
View article: Adaptive infusion of a glucagon‐like peptide‐1/glucagon receptor co‐agonist <scp>G3215</scp> , in adults with overweight or obesity: Results from a phase 1 randomized clinical trial
Adaptive infusion of a glucagon‐like peptide‐1/glucagon receptor co‐agonist <span>G3215</span> , in adults with overweight or obesity: Results from a phase 1 randomized clinical trial Open
Aims To determine whether a continuous infusion of a glucagon‐like peptide receptor (GLP‐1R)/glucagon receptor (GCGR) co‐agonist, G3215 is safe and well tolerated in adults with overweight or obesity. Methods A phase 1 randomized, double b…
View article: Adrenal Vein Sampling: Does the Location of the Non-adrenal Venous Sample Matter?
Adrenal Vein Sampling: Does the Location of the Non-adrenal Venous Sample Matter? Open
Purpose Adrenal vein sampling (AVS) is used to lateralise and differentiate unilateral from bilateral aldosterone production in primary aldosteronism. The adrenal venous samples are standardised to a peripheral or low inferior vena cava (I…
View article: Thyrotoxicosis due to Gestational Trophoblastic Disease: Unmet Needs in the Management of Gestational Thyrotoxicosis
Thyrotoxicosis due to Gestational Trophoblastic Disease: Unmet Needs in the Management of Gestational Thyrotoxicosis Open
Thyrotoxicosis during pregnancy is rare but can have severe adverse consequences for the mother or foetus if left undiagnosed and untreated. It can be caused by an underlying thyroid disease or develop as gestational transient thyrotoxicos…
View article: Increased glycemic variability in pregnant women with Roux-en-Y gastric bypass compared with sleeve gastrectomy
Increased glycemic variability in pregnant women with Roux-en-Y gastric bypass compared with sleeve gastrectomy Open
Introduction Bariatric surgery is associated with adverse pregnancy outcomes such as reduced birth weight and premature birth. One possible mechanism for this is increased glycemic variability (GV) which occurs after bariatric surgery. The…
View article: Call for prospective studies of continuous glucose monitoring to define the glycaemic response to bariatric surgery
Call for prospective studies of continuous glucose monitoring to define the glycaemic response to bariatric surgery Open
View article: Sleeve gastrectomy causes weight‐loss independent improvements in hepatic steatosis
Sleeve gastrectomy causes weight‐loss independent improvements in hepatic steatosis Open
Background and Aims Sleeve gastrectomy (VSG) leads to improvement in hepatic steatosis, associated with weight loss. The aims of this study were to investigate whether VSG leads to weight‐loss independent improvements in liver steatosis in…
View article: Commentary on “The road to reliable peptide assays is paved with good guidelines”
Commentary on “The road to reliable peptide assays is paved with good guidelines” Open
We note that Maurer et al., in their correspondence,1 have raised some concerns about the preanalytical and analytical validation of the peptide YY (PYY) assay described in our paper ‘The postprandial secretion of peptide YY1–36 and 3–36 i…
View article: The postprandial secretion of peptide YY<sub>1‐36</sub> and <sub>3‐36</sub> in obesity is differentially increased after gastric bypass versus sleeve gastrectomy
The postprandial secretion of peptide YY<sub>1‐36</sub> and <sub>3‐36</sub> in obesity is differentially increased after gastric bypass versus sleeve gastrectomy Open
Objectives Peptide tyrosine tyrosine (PYY) exists as two species, PYY 1‐36 and PYY 3‐36 , with distinct effects on insulin secretion and appetite regulation. The detailed effects of bariatric surgery on PYY 1‐36 and PYY 3‐36 secretion are …
View article: Letter to the editor of clinical endocrinology: Assessment of adrenal function in patients who survive COVID‐19
Letter to the editor of clinical endocrinology: Assessment of adrenal function in patients who survive COVID‐19 Open
It is widely recognised that the effects of COVID-19 extend beyond the respiratory system. Moreover, there are an estimated 1.3 million people living with Long COVID (symptoms persisting beyond 12 weeks after infection) in the UK alone.
View article: Ockham’s Razor for a Retinal Lesion and Acromegaly and Breaking the Vicious Circle
Ockham’s Razor for a Retinal Lesion and Acromegaly and Breaking the Vicious Circle Open
Acromegaly due to ectopic secretion of growth hormone-releasing hormone (GHRH) is rare. Treatment consists of surgical removal of the primary tumor, cytostatic therapy, “cold” or radioactive somatostatin analogue treatment, and medical the…
View article: A Comparison of the Blood Glucose, Growth Hormone, and Cortisol Responses to Two Doses of Insulin (0.15 U/kg vs. 0.10 U/kg) in the Insulin Tolerance Test: A Single-Centre Audit of 174 Cases
A Comparison of the Blood Glucose, Growth Hormone, and Cortisol Responses to Two Doses of Insulin (0.15 U/kg vs. 0.10 U/kg) in the Insulin Tolerance Test: A Single-Centre Audit of 174 Cases Open
Objective. The insulin tolerance test (ITT) is the gold standard endocrine test used to assess the integrity of the growth hormone (GH) and cortisol axes. The ITT has potential risks, and severe hypoglycaemia may necessitate intravenous gl…
View article: Preserved <scp>C</scp> ‐peptide in survivors of <scp>COVID</scp> ‐19: Post hoc analysis
Preserved <span>C</span> ‐peptide in survivors of <span>COVID</span> ‐19: Post hoc analysis Open
Hyperglycaemia1 and new diagnoses of diabetes (including autoantibody-negative type 1 diabetes2) have been reported in patients with coronavirus disease 2019 (COVID-19).1 Moreover, 77% of patients with COVID-19 and ketoacidosis (a conditio…
View article: Metastatic Medullary Thyroid Cancer: The Role of 68Gallium-DOTA-Somatostatin Analogue PET/CT and Peptide Receptor Radionuclide Therapy
Metastatic Medullary Thyroid Cancer: The Role of 68Gallium-DOTA-Somatostatin Analogue PET/CT and Peptide Receptor Radionuclide Therapy Open
Context Metastatic medullary thyroid cancer (MTC) is a rare malignancy with minimal treatment options. Many, but not all, MTCs express somatostatin receptors. Objective Our aim was to explore the role of 68Ga-DOTA-somatostatin analogue (SS…
View article: Tirzepatide and the new era of twincretins for diabetes
Tirzepatide and the new era of twincretins for diabetes Open
View article: Normal Adrenal and Thyroid Function in Patients Who Survive COVID-19 Infection
Normal Adrenal and Thyroid Function in Patients Who Survive COVID-19 Infection Open
Context The COVID-19 pandemic continues to exert an immense burden on global health services. Moreover, up to 63% of patients experience persistent symptoms, including fatigue, after acute illness. Endocrine systems are vulnerable to the e…
View article: Thyroid Function Before, During and After COVID-19
Thyroid Function Before, During and After COVID-19 Open
Context: The effects of COVID-19 on the thyroid axis remain uncertain. Recent evidence has been conflicting, with both thyrotoxicosis and suppression of thyroid function reported. Objective: We aimed to detail the acute effects of COVID-19…
View article: Weight Loss With a Novel Peptide YY Analogue for Obesity: A Randomised, Placebo-Controlled Phase I Trial
Weight Loss With a Novel Peptide YY Analogue for Obesity: A Randomised, Placebo-Controlled Phase I Trial Open
Background: Obesity and its co-morbidities remain a prime driver of global morbidity and mortality. Current therapies for obesity are limited in efficacy and durability, have serious adverse effects or are not scalable to the numbers requi…
View article: Author response for "Misleading 68 GALLIUM‐dotatate PET scan in a patient with a history of a phaeochromocytoma: Unsuspected uptake in papillary thyroid carcinoma metastases"
Author response for "Misleading 68 GALLIUM‐dotatate PET scan in a patient with a history of a phaeochromocytoma: Unsuspected uptake in papillary thyroid carcinoma metastases" Open
View article: Safety and efficacy of an extended‐release peptide <scp>YY</scp> analogue for obesity: A randomized, placebo‐controlled, phase <scp>1</scp> trial
Safety and efficacy of an extended‐release peptide <span>YY</span> analogue for obesity: A randomized, placebo‐controlled, phase <span>1</span> trial Open
Aim To report the results from a Phase 1 trial of an extended‐release peptide YY analogue, Y14, developed for the treatment of obesity. Methods Y14 was evaluated in overweight/obese volunteers in a Phase 1 randomized placebo‐controlled tri…
View article: Author response for "Safety and Efficacy of an Extended‐Release Peptide YY Analogue for Obesity: a Randomised, Placebo‐Controlled , Phase 1 Trial"
Author response for "Safety and Efficacy of an Extended‐Release Peptide YY Analogue for Obesity: a Randomised, Placebo‐Controlled , Phase 1 Trial" Open
View article: Roux-en-Y gastric bypass increases glycaemic variability and time in hypoglycaemia in patients with obesity and pre-diabetes/type 2 diabetes mellitus: a prospective cohort study
Roux-en-Y gastric bypass increases glycaemic variability and time in hypoglycaemia in patients with obesity and pre-diabetes/type 2 diabetes mellitus: a prospective cohort study Open
Objective: Roux-en-Y gastric bypass (RYGB) is an established treatment for type 2 diabetes. The study objective was to establish RYGB’s effects on glycaemic variability (GV) and hypoglycaemia. Research Design and Methods: Pro…