Bernard Turcotte
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View article: Mitochondrial defects result in decreased susceptibility to echinocandins via the transcriptional regulator Pdr1 in <i>Candida glabrata</i>.
Mitochondrial defects result in decreased susceptibility to echinocandins via the transcriptional regulator Pdr1 in <i>Candida glabrata</i>. Open
In the human fungal pathogen Candida glabrata , the transcription factor Pdr1 controls the expression of genes encoding drug efflux pumps such as Cdr1. Pdr1 also controls its own expression by binding to pleiotropic drug responsive element…
View article: Regulation of meiotic gene expression is functional in the human fungal pathogen <i>Candida glabrata</i>
Regulation of meiotic gene expression is functional in the human fungal pathogen <i>Candida glabrata</i> Open
The human fungal pathogen Candida glabrata is closely related to the budding yeast Saccharomyces cerevisiae. The sexual cycle in S. cerevisiae has been extensively characterized. Haploid cells ‘a’ and alpha secrete pheromones involved in m…
View article: Yeast zinc cluster transcription factors involved in the switch from fermentation to respiration show interdependency for DNA binding revealing a novel type of DNA recognition
Yeast zinc cluster transcription factors involved in the switch from fermentation to respiration show interdependency for DNA binding revealing a novel type of DNA recognition Open
In budding yeast, fermentation is the most important pathway for energy production. Under low-glucose conditions, ethanol is used for synthesis of this sugar requiring a shift to respiration. This process is controlled by the transcription…
View article: Editorial: Functional Genomics of Transcriptional Regulation in Pathogenic Fungi
Editorial: Functional Genomics of Transcriptional Regulation in Pathogenic Fungi Open
EDITORIAL article Front. Cell. Infect. Microbiol., 01 June 2022Sec. Fungal Pathogenesis https://doi.org/10.3389/fcimb.2022.928440
View article: A <i>lacZ</i> reporter with high activity in the human fungal pathogen <i>Candida albicans</i>
A <i>lacZ</i> reporter with high activity in the human fungal pathogen <i>Candida albicans</i> Open
Reporter genes are useful tools to study gene transcription in various organisms. For example, the lacZ gene encoding β-galactosidase has been extensively used as a reporter in bacteria, budding yeast, fruit fly, mouse etc. However, use of…
View article: A SKI subcomplex specifically required for the degradation of ribosome-free RNA regions
A SKI subcomplex specifically required for the degradation of ribosome-free RNA regions Open
Summary The Ski2-Ski3-Ski8 (SKI) complex assists the RNA exosome during the 3’-5’ degradation of cytoplasmic transcripts. Previous reports showed that the SKI complex is involved in the 3’-5’ degradation of mRNA, including 3’ untranslated …